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Live show? Thank you so much to the organizers of the ACNP/PA Critical Care Bootcamp who invited us to do a live episode of the show! We talked about the AKIKI2 trial "Comparison of two delayed strategies for renal replacement therapy initiation for severe acute kidney injury" by Gaudry et al in Lancet 2021.

AKIKI2: https://pubmed.ncbi.nlm.nih.gov/33812488/

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at [email protected] with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

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Episode 21! In this episode we talk about "Extracorporeal Life Support in Infarct-Related Cardiogenic Shock" published August 2023 by Thiele et al in NEJM. Then we dive into our neglected mail bad to try to answer some listener questions.

ECLS-SHOCK: https://pubmed.ncbi.nlm.nih.gov/37634145/

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at [email protected] with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

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Episode 20! In this episode we talk about "Effect of Selective Decontamination of the Digestive Tract on Hospital Mortality in Critically Ill Patients Receiving Mechanical Ventilation" published October 2022 by the ANZICS group in JAMA. We have the first author and senior authors on the accompanying systematic review and meta-analysis, Naomi Hammond and Anthony Delany, all the way from Australia (!) on with us to talk to us about the trial.

SuDDICU: https://pubmed.ncbi.nlm.nih.gov/36286097/
Meta-analysis: https://pubmed.ncbi.nlm.nih.gov/36286098/

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at [email protected] with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

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Episode 19! In this episode we talk about "Oxygen-Saturation Targets for Critically Ill Adults Receiving Mechanical Ventilation" published November 2022 by Semler et al in the New England Journal of Medicine. We have the first author, Matt Semler, on with us to talk to us about the trial and his improv comedy claim to fame.

PILOT: https://pubmed.ncbi.nlm.nih.gov/36278971/

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at [email protected] with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

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Episode 18! In this episode we talk about "Early adjunctive methylene blue in patients with septic shock: a randomized controlled trial" published March 2023 by Ibarra-Estrada et al in Critical Care. We made a planning mistake so no old article today so we left it short!

Methylene blue: https://pubmed.ncbi.nlm.nih.gov/36915146/

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at [email protected] with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

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Episode 17! In this episode we talk about "Aggressive of Moderate Fluid Resuscitation in Acute Pancreatitis" published September 2022 by de-Madaria et al in the New England Journal of Medicine and then talk about the landmark study "Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock" by Rivers et al also NEJM but November 2001

WATERFALL: https://pubmed.ncbi.nlm.nih.gov/36103415/
EGDT: https://pubmed.ncbi.nlm.nih.gov/11794169/

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at [email protected] with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

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Episode 16! In this episode we talk about "Phenobarbital-Based Protocol for Alcohol Withdrawal Syndrome in a Medical ICU: Pre-Post Implementation Study" published April 2023 by Alwakeel et al and then talk about the landmark study TRICC or "A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care"

We also explore car donation jingles (1-877 KARS 4 KIDS

Phenobarbital: https://pubmed.ncbi.nlm.nih.gov/37091477/
TRICC: https://pubmed.ncbi.nlm.nih.gov/9971864/
TRISS: https://pubmed.ncbi.nlm.nih.gov/23281973/
Transfusion in Upper GI bleeds: https://pubmed.ncbi.nlm.nih.gov/25270275/

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at [email protected] with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

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Episode 15! In this episode we talk about "Blood-Pressure Targets in Comatose Survivors of Cardiac Arrest" published October 2022 by Kjaergaard (apologies in advance for the pronounciation...) et al and then talk about the prospective observational cohort "Weaning from mechanical ventilation in intensive care units across 50 countries (WEAN SAFE)"

BOX-BP: https://pubmed.ncbi.nlm.nih.gov/36027564/
WEAN SAFE: https://pubmed.ncbi.nlm.nih.gov/36693401/
CT scan after cardiac arrest: https://pubmed.ncbi.nlm.nih.gov/37019352/

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at [email protected] with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

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Summer is here and we're getting a chance to catch our breath! Unless there is a surprise article drop we anticipate that our next few episodes are going to be a little bit different as we catch up on non-RCT happenings in the critical care world. This episode is the same, our discussion on ARDS is a fascinating history lesson blended in with current insights.

ARDS Guidelines: https://pubmed.ncbi.nlm.nih.gov/37326646/
ARMA: https://pubmed.ncbi.nlm.nih.gov/10793162/

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at [email protected] with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

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Episode 13! We made it this far! Instead of keying in on one major article from the Critical Care Reviews Conference 2023 we decided to do a pot pourri of the entire conference. It was quite the whirlwind, if there is any point or trial you want us to elaborate please contact us and let us know!

Otherwise we discuss EXIT-SEP in our "short" discussion section. This was published in JAMA Internal Medicine by Liu et al evaluating XueBiJing Injection versus placebo in patients with sepsis. 

EXIT-SEP: https://pubmed.ncbi.nlm.nih.gov/37126332/

As always, if you appreciate the content please share with friends or social media!

If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at [email protected] with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!