Join Jame as he continues to talks through the ESCMID and IDSA treatment of Multi Drug Resistant Gram negative guidelines/guidance. Callum listens and occasionally asks a question! Jame is so passionate on this subject that we have split the episode into two parts.

ECDC guidelines

·          https://onlinelibrary.wiley.com/doi/full/10.1111/j.1469-0691.2011.03570.x

·          https://www.ecdc.europa.eu/en/news-events/multidrug-resistant-extensively-drug-resistant-and-pandrug-resistant-bacteria-0

 Canadian guidelines

·          https://www.canada.ca/content/dam/phac-aspc/documents/services/reports-publications/canada-communicable-disease-report-ccdr/monthly-issue/2018-44/ccdr-volume-44-1-january-4-2018/ccdr-rmtc-44-1-ar07-eng.pdf

 IDSA

-       https://www.idsociety.org/practice-guideline/amr-guidance-2.0/# 

 Comparison of IDSA and ESCMID

-       https://www.clinicalmicrobiologyandinfection.com/article/S1198-743X(22)00054-4/fulltext 

-       https://amr.solutions/2019/01/13/categories-of-resistance-mdr-xdr-pdr-udr-and-new-dtr/

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Join Jame as he talks through the ESCMID and IDSA treatment of Multi Drug Resistant Gram negative guidelines/guidance. Callum listens and occasionally asks a question! Jame is so passionate on this subject that we have split the episode into two parts.

ECDC guidelines

·          https://onlinelibrary.wiley.com/doi/full/10.1111/j.1469-0691.2011.03570.x

·          https://www.ecdc.europa.eu/en/news-events/multidrug-resistant-extensively-drug-resistant-and-pandrug-resistant-bacteria-0

 Canadian guidelines

·          https://www.canada.ca/content/dam/phac-aspc/documents/services/reports-publications/canada-communicable-disease-report-ccdr/monthly-issue/2018-44/ccdr-volume-44-1-january-4-2018/ccdr-rmtc-44-1-ar07-eng.pdf

 IDSA

-       https://www.idsociety.org/practice-guideline/amr-guidance-2.0/# 

 Comparison of IDSA and ESCMID

-       https://www.clinicalmicrobiologyandinfection.com/article/S1198-743X(22)00054-4/fulltext 

-       https://amr.solutions/2019/01/13/categories-of-resistance-mdr-xdr-pdr-udr-and-new-dtr/

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Questions, comments, suggestions to [email protected] or on Bluesky @idiots-pod.bsky.social

Prep notes for completed episodes can be found here (Not all episodes have prep notes).

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ID:IOTS is 1 year old today! Jame and Callum have a short chat about the the podcast, why we started and where we’re going. Of course, the real ID:IOTS are the friends we made along the way…

If you want to send us cake email [email protected]

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Prep notes for completed episodes can be found here (Not all episodes have prep notes).

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Back after a summer break, Jame and Callum discuss the fascinating machine that is the MALDI-TOF. Matrix Assisted Laser Desorption Ionisation Time Of Flight mass spectrometry. We discuss the basics of how it functions, its application in the lab and some pros and cons of its use along with what the future may hold. Here are some relevant videos and papers:

- Exciting video of MALDI-TOF
https://www.youtube.com/watch?v=0jeFpXHZ8W0&ab_channel=BrukerDaltonics
- MALDI-TOF to detect MRSA https://www.frontiersin.org/articles/10.3389/fmicb.2020.00232/full
- Direct MALDI-TOF on blood cultures 
https://www.spandidos-publications.com/10.3892/etm.2020.9365
- MALDI-TOF to detect CPE
https://www.frontiersin.org/articles/10.3389/fmicb.2021.789731/full 

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Join Jame and Callum as they discussion all things beta lactamase including ESBL, AmpC and Carbapenemases.  We talk through classification systems, patterns of resistance and some methods of detection. 

Some resources we found helpful:

Summary of beta lactamase classification:
https://microbeonline.com/betalactamase-classification/

Summary of AmpC:
https://www.idstewardship.com/heck-yes-get-amped-updates-ampc-harboring-bacteria/

EUCAST detection of resistance:
https://www.eucast.org/fileadmin/src/media/PDFs/EUCAST_files/Resistance_mechanisms/EUCAST_detection_of_resistance_mechanisms_170711.pdf

UK SMI on Carbapenemases:
https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/1080594/B_60i3.1.pdf

More in depth AmpC:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6763639/

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Prep notes for completed episodes can be found here (Not all episodes have prep notes).

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Callum and Jame provide an overview of the Carbapenem class of antibiotics discussing: what they are; their spectrum of action (looking in particular at what they don't cover); resistance; how to use them; and side effects.

This site has a useful summary of the new formulation of carbapenems and their spectra:
http://www.microbiologynutsandbolts.co.uk/the-bug-blog/new-sweets-on-the-market-but-will-these-new-flavours-live-up-to-their-vibrant-colours

Here is the NEJM paper on Tebipenem Jame mentions:
https://www.nejm.org/doi/full/10.1056/NEJMoa2105462

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Jame and Callum continue their discuss of the Enterobacterales, looking at Klebsiella spp. with focused discussion on some microbiological history, K1 syndrome, and the pharmacokinetics of antimicrobials for endophthalmitis.

For the graphic Jame suggested look at Figure 4 in this paper:  https://academic.oup.com/femsre/article/41/3/252/3830265

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Jame and Callum have put this off for far too long... we start exploring the Gram negative bacilli by considering Enterobacterales in general and then discussing E. coli. We focus particularly on the gastrointestinal syndromes causes by different pathogenic strains of E. coli. Did you ever wonder what "coliforms" on a culture result meant - hopefully now you will find out!

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In this episode Jame and Callum discuss other Beta-lactam antibiotics: aztreonam, temocillin and pivmecillinam... with some substantial tangents into C. difficle and carbapenems. 

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In this episode Jame and Callum talk through the two most medically important Gram negative cocci: Neisseria meningitidis and Neisseria gonorrhoeae.

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Questions, comments, suggestions to [email protected] or on Bluesky @idiots-pod.bsky.social

Prep notes for completed episodes can be found here (Not all episodes have prep notes).

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Feel like giving back? Donations of caffeine gratefully received!
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