Inside Exercise

Inside Exercise

By Glenn McConellHealth & FitnessFitness
Download on the App Store

Inside Exercise episodes

  • #80 - Epigenetics of exercise adaptation and "muscle memory" with Dr Kevin Murach

    Dr Glenn McConell chats with Assistant Professor Kevin Murach who is a rising star from the University of Arkansas, USA. Kevin is an expert on muscle, muscle growth, adaptation to exercise training, “muscle memory”, the regulation of muscle growth and muscle memory and the effect of aging etc. Muscle memory definitely seems real (especially in slow muscle fibers). Looks like epigenetics involved more than changes to muscle fibers nuclei. But more work needs to be done, especially in humans. We had a really great chat. I enjoyed it a lot. A very smart chap. Twitter: @KevinMurachPhD
    0:00. Introduction and welcome
    2:16. How Kevin got into exercise research
    6:53. What is “muscle memory”.
    9:15. Human evidence of muscle memory
    13:58. Mice models to investigate resistance training
    19:30. Training, detraining and retraining
    20:35. Comparing rodents and human re their different lifespans
    22:30. Evidence for muscle memory in mice after ex training
    31:05. Mouse model that has both endurance and strength effects
    33:25. Voluntary wheel running: matching the training
    35:45. 10% greater hypertrophy with retraining
    39:25. Mice slow postural muscles didn’t detrain!
    44:45. Mechanisms: epigenetics
    49:50. Muscle nuclei and exercise training/muscle memory
    1:02:00. Muscle memory and epigenetics in the nuclei
    1:05:40. MicroRNA and muscle memory
    1:07:30. Epigenetics
    1:08:35. Exercise training and each bout of exercise
    1:11:20. MicroRNA and muscle memory
    1:16:20. Balance of protein synthesis and breakdown
    1:20:20. Muscle memory: Endurance vs resistance training
    1:21:35. Time course of muscle memory
    1:23:55. How much training need to get muscle memory
    1:25:18. Specificity of ex training muscle memory
    1:26:40. Nature and nuture
    1:27:25. Dutch famine and epigenetics
    1:28:18. Age and muscle memory
    1:29:38. Biological sex and muscle memory
    1:30:40. Common misconceptions: use it or lose it
    1:31:38. Identical twins
    1:32:25. Don’t need to go hard or go home.
    1:33:05. Research experts vs influencers etc
    1:37:15. Takeaway messages
    1:39:44. Do health benefits have a memory too?
    1:41:45. Outro

    Inside Exercise brings to you the who's who of research in exercise metabolism, exercise physiology and exercise’s effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all.
    The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University.
    He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (https://link.springer.com/book/10.1007/978-3-030-94305-9).
    Connect with Inside Exercise and Glenn McConell at:
    Twitter: @Inside_exercise and @GlennMcConell1
    Instagram: insideexercise
    Facebook: Glenn McConell
    LinkedIn: Glenn McConell https://www.linkedin.com/in/glenn-mcconell-83475460
    ResearchGate: Glenn McConell
    Email: [email protected]
    Subscribe to Inside exercise:
    Spotify: shorturl.at/tyGHL
    Apple Podcasts: shorturl.at/oFQRU
    YouTube: https://www.youtube.com/@insideexercise
    Anchor: https://anchor.fm/insideexercise
    Google Podcasts: shorturl.at/bfhHI
    Anchor: https://anchor.fm/insideexercise
    Podcast Addict: https://podcastaddict.com/podcast/4025218
    Not medical advice

    1 hr 42 min
  • #78 - Food, exercise and glucose "spikes": should everyone wear a CGM? Glucose spikes are normal physiology!! With Dr Guess and Prof Little

    Dr Glenn McConell chats with Dr Nicola Guess from Oxford University, England and Professor Jonathan Little from the University of British Columbia, Canada. Nicola is a dietitian researcher with many years of expertise including the importance or otherwise of glucose “spikes” or excursions and the pros and cons of continuous glucose monitor use. Jonathan is an expert on exercise metabolism who is coming onto the podcast for the second time after speaking previously about keto diets and exercise. A major point is the difference between having chronically elevated blood glucose levels such as in diabetes (pathology) versus having normal increases in glucose ("spikes") in response to a meal. Also increases in glucose before and during very intense exercise is normal physiology and not a concern. There was also a clear message that the use of continuous glucose monitors (CGMs) have both pros and cons and that need to be considered. A very interesting chat. Twitter: @DrJonLittle
    0:00. Introduction and welcome
    3:20. What are glucose “spikes”/excursions
    4:45. Hyperglycemia in diabetes is very different to “spikes”
    6:20. Glucose spikes in type 2 diabetes
    7:19. Why is chronically elevated glucose a problem?
    12:20. Confusion about glucose levels 2hrs after a meal
    15:29. Underlying insulin resistance the problem not spikes
    19:08. Fasting glucose and insulin measures
    21:10. Meal tests and oral glucose tolerance tests
    24:55. Be careful not to make the underlying pathology worse
    26:15. Keto diets: T2D, weight loss, exercise
    32:10. Glucose even in diabetes is not as important as we think
    35:00. Are CGMs useful?
    38:30. Too much focus on glucose than more important things
    41:00. CGMs very important for people with T1D
    42:05. CGMs and anxiety
    43:25. CGMs and higher cholesterol
    44:00. Misunderstanding of pre-diabetes re CGMs
    46:00. Metabolic flexibility
    47:40. “Nervous normals”
    49:42. Is how loses weight important?
    53:41. What about CGMs in type 1 diabetes?
    54:15. CGMs, diabetes, diet, behaviour change and exercise
    57:40. Glucose metabolism during exercise
    59:55. Exercise and insulin sensitivity
    1:02:15. Effect of exercise on glucose spikes from a meal
    1:04:10. Intense exercise can increase blood glucose levels
    1:07:10. Normal to have elevated glucose after intense exercise
    1:09:50. Influencers misinterpreting data re glucose spikes etc
    1:12:10. Misunderstanding glucose cut offs
    1:13:10. Takeaway messages etc
    1:14:00. Weight loss diet strategies
    1:17:50. Amino acids and insulin secretion
    1:24:40. Should everyone use CGMs?
    1:26:30. Keep it simple re diet and exercise
    1:27:40. Outro
    Inside Exercise brings to you the who's who of research in exercise metabolism, exercise physiology and exercise’s effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all.
    The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University.
    He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (https://link.springer.com/book/10.1007/978-3-030-94305-9).
    Connect with Inside Exercise and Glenn McConell at:
    Twitter: @Inside_exercise and @GlennMcConell1
    Instagram: insideexercise
    Facebook: Glenn McConell
    LinkedIn: Glenn McConell https://www.linkedin.com/in/glenn-mcconell-83475460
    ResearchGate: Glenn McConell
    Email: [email protected]
    Subscribe to Inside exercise:
    Spotify: shorturl.at/tyGHL
    Apple Podcasts: shorturl.at/oFQRU
    YouTube: https://www.youtube.com/@insideexercise
    Anchor: https://anchor.fm/insideexercise
    Google Podcasts: shorturl.at/bfhHI
    Anchor: https://anchor.fm/insideexercise
    Podcast Addict: https://podcastaddict.com/podcast/4025218
    Not medical advice

    1 hr 28 min
  • #79 - Exercise and the brain with Dr Jill Barnes

    Dr Glenn McConell chats with Associate Professor from the University of Wisconsin-Madison, USA. Jill is an expert on the brain and exercise. We discussed the effect of acute (one bout) and chronic physical activity/ exercise on cognitive function, brain blood flow (BBF), dementia/Alzheimer’s disease risk and progression etc. A very interesting chat. Twitter: @Barnes_Lab
    0:00. Introduction and welcome
    2:01. How Jill got into exercise research
    4:25. Studying with Hiro O. Tanaka
    6:00. Researching with Michael Joyner
    7:45. How measure brain blood flow (BBF)
    10:00. Blood vessels that supply the brain and blood flow
    19:16. What would look at if had unlimited funding?
    20:32. BBF vs glucose use in the brain
    21:30. Regional blood flow in the brain
    22:40. Does BBF increase during exercise?
    24:40. Blood pressure and regulation of brain blood flow
    29:00. Effect of exercise intensity in BBF
    32:25. Hypnosis/anticipatory rises in BBF
    34:30. BBF distribution has not been examined much during exercise
    37:00. Cognitive tests and BBF
    38:00. Why does BBF decrease during very intense exercise?
    41:00. Central fatigue and BBF
    42:30. Exercise training and BBF
    45:00. BBF and cognitive function
    46:20. How quickly does BBF increase with exercise?
    47:25. Fitness and BBF at rest
    49:55. Cognition and exercise/lifestyle
    51:44. Exercjse intensity and the brain
    53:10. Resistance training and cognitive function
    55:07. Exercise and brain endothelial function
    57:10. Exercise and the risk of stroke
    59:35. Exercise and the risk of dementia/Alzheimers disease
    1:02:14. Exercise and mental health
    1:03:45. Diet and BBF/brain health
    1:06:15. Sex differences in BBF
    1:12:57. Age and BBF
    1:15:20. Fitness/strength and cognition etc
    1:16:10. Erythropoietin, hemoglobin and cognitive function.
    1:18:48. Exercise and myokines, BDNF, exosomes
    1:21:10. Neurogenesis and exercise
    1:22:20. Exercise, cognition and hypertension/diabetes
    1:25:00. Prevention of Alzheimer’s disease/dementia
    1:27:00. Exercise intensity and mode of exercise
    1:29:55. BBF during resistance exercise
    1:31:20. Controversies in the field
    1:34:52. Keep things simple re exercise
    1:37:00. Takeaway messages
    1:39:57. Outro

    Inside Exercise brings to you the who's who of research in exercise metabolism, exercise physiology and exercise’s effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all.
    The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University.
    He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (https://link.springer.com/book/10.1007/978-3-030-94305-9).
    Connect with Inside Exercise and Glenn McConell at:
    Twitter: @Inside_exercise and @GlennMcConell1
    Instagram: insideexercise
    Facebook: Glenn McConell
    LinkedIn: Glenn McConell https://www.linkedin.com/in/glenn-mcconell-83475460
    ResearchGate: Glenn McConell
    Email: [email protected]
    Subscribe to Inside exercise:
    Spotify: shorturl.at/tyGHL
    Apple Podcasts: shorturl.at/oFQRU
    YouTube: https://www.youtube.com/@insideexercise
    Anchor: https://anchor.fm/insideexercise
    Google Podcasts: shorturl.at/bfhHI
    Anchor: https://anchor.fm/insideexercise
    Podcast Addict: https://podcastaddict.com/podcast/4025218
    Not medical advice

    1 hr 41 min
  • #77 - Exercise and pregnancy with Professor Margie Davenport

    Dr Glenn McConell chats with Professor Margie Davenport from the University of Alberta, Canada. She is an expert on exercise and pregnancy. We discussed the effect of pregnancy on the health (including pre-eclampsia and gestational diabetes) and exercise performance of the mother and on the health of the fetus during pregnancy and the offspring after pregnancy. It became very clear that there needs to be more focus on the beneficial effects of exercise before and during pregnancy on both the mother and the fetus/offspring. A very interesting chat. Twitter: @ExercisePreg
    0:00. Introduction
    2:09. How Margie went from top athlete to exercise researcher
    6:15. History of thinking on exercise and pregnancy
    8:49. What intensity of exercise should do during pregnancy?
    12:28. Fetal heart rate during mothers exercise
    14:10. HIIT exercise during pregnancy
    15:55. Monitoring the baby during exercise research
    19:50. Contraindications for exercise during pregnancy
    20:38. Different types of exercise
    21:49. Effect of the initial fitness of the mother
    24:15. Heavy lifting during pregnancy
    29:00. Effect of exercise on placenta blood flow
    30:03. Animal studies: effect of exercise on the fetus
    33:25. Health outcomes better when exercise during pregnancy
    35:45. Reduced pre-eclampsia when exercise during pregnancy
    44:25. Effect of exercise during pregnancy in elite athletes
    45:40. Exercise during pregnancy and offspring health
    49:07. Effect of pregnancy trimester/stage on exercise
    52:40. Contraindications for exercise during pregnancy
    55:05. Speaking with health care provider
    57:13. Miscarriage levels during the first trimester and exercise
    1:01:26. Individualized approach to exercise during pregnancy
    1:03:15. Relaxin and pregnancy
    1:04:20. Exercise during pregnancy and birth weight
    1:06:15. Gestational diabetes and exercise
    1:10:05. Exercise reduces gestational diabetes
    1:11:55. Exercise before pregnancy vs during vs both
    1:15:10. Exercise during pregnancy and mental health
    1:19:05. Athletes and returning to sport after pregnancy
    1:25:35. “Pregnancy advantage” from childbirth?
    1:29:05. Diet during pregnancy and sport
    1:32:09. Effect of the age of the mother
    1:34:30. Research controversies in the field
    1:36:50. Insufficient research in women/pregnancy
    1:38:39. Misinformation in the area on social media etc
    1:41:50. Takeaway messages etc
    1:45:48. Outro
    Inside Exercise brings to you the who's who of research in exercise metabolism, exercise physiology and exercise’s effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all.
    The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University.
    He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (https://link.springer.com/book/10.1007/978-3-030-94305-9).
    Connect with Inside Exercise and Glenn McConell at:
    Twitter: @Inside_exercise and @GlennMcConell1
    Instagram: insideexercise
    Facebook: Glenn McConell
    LinkedIn: Glenn McConell https://www.linkedin.com/in/glenn-mcconell-83475460
    ResearchGate: Glenn McConell
    Email: [email protected]
    Subscribe to Inside exercise:
    Spotify: shorturl.at/tyGHL
    Apple Podcasts: shorturl.at/oFQRU
    YouTube: https://www.youtube.com/@insideexercise
    Anchor: https://anchor.fm/insideexercise
    Google Podcasts: shorturl.at/bfhHI
    Anchor: https://anchor.fm/insideexercise
    Podcast Addict: https://podcastaddict.com/podcast/4025218
    Not medical advice

    1 hr 46 min
  • #76 - Creatine in exercise and health with Professor Darren Candow

    Dr Glenn McConell chats with Professor Darren Candow from the University of Regina. Saskatchewan, Canada. He is an expert on creatine (Cr) and the effects of creatine supplementation on resistance exercise and other exercise. He is also examining the role of creatine in bone metabolism and cognitive function.
    Get greater increases in strength than muscle mass when supplement with Cr during resistance training. Vegetarians/vegans have lower muscle but not lower brain Cr. Need to exercise to get benefits of Cr on muscle. Lots more. A very interesting chat. Twitter: @darrencandow
    0:00. Introduction
    1:40. How Darren got into exercise research
    4:15. The early pioneers of creatine and other exercise research
    7:30. What is creatine (Cr) and where get it from?
    9:30. Do people need Cr and other supplements?
    11:50. Effects of Cr supplementation on muscle Cr
    14:10. Cr vs creatine phosphate (ATP and H+ buffering)
    20:12. How Cr/creatine phosphate effects exercise performance
    23:30. Cr supplementation and resistance training
    26:30. Vegetarians/vegans and Cr
    28:15. Aging and Cr
    29:40. Mechanisms that Cr effects exercise performance
    33:44. Does Cr increase strength/muscle more if control volume?
    40:10. Pre print means not reviewed/published
    42:15. Cr causes cell swelling but need exercise
    43:40. Use it or lose it
    45:10. Cr suppl: how much?
    50:40. Cr transporter and muscle creatine levels
    52:40. Does age or biological sex affect Cr levels?
    54:30. What % increase with Cr suppl during resistance training
    55:40. Dissociation of muscle mass and strength
    1:00:15. Cr suppl has no effect on fat mass
    1:01:15. Cr suppl timing/anti-inflammatory effects
    1:05:15. Keep it simple and food first
    1:06:45. Top sprinters, vegetarians/vegan and Cr
    1:09:00. Time for Cr to decrease after stop Cr suppl
    1:10:10. Side effects of Cr suppl?
    1:12:00. Sarcopenia, resistance training and Cr
    1:14:40. Bone and Cr suppl
    1:20:12. The brain and Cr suppl
    1:27:00. If brain is compromised Cr suppl may be beneficial
    1:28:55. Who can Cr suppl benefit
    1:31:50. Do untrained vegetarians/vegans need Cr suppl?
    1:35:50. Need to exercise for Cr suppl to have any effect
    1:40:10. Caffeine and creatine may interfere with eachother
    1:43:40. Can put Cr suppl in coffee?
    1:44:12. CHO (insulin) and protein can increases Cr uptake
    1:45:19. Volume of resistance training and Cr suppl
    1:46:10. Depression and creatine
    1:47:08. Surprises with Cr research
    1:48:15. Controversies in the field
    1:51:15. Need to be careful with info on social media
    1:53:42. Takeaway messages
    1:54:46. Outro

    Inside Exercise brings to you the who's who of research in exercise metabolism, exercise physiology and exercise’s effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all.
    The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University.
    He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (https://link.springer.com/book/10.1007/978-3-030-94305-9).
    Connect with Inside Exercise and Glenn McConell at:
    Twitter: @Inside_exercise and @GlennMcConell1
    Instagram: insideexercise
    Facebook: Glenn McConell
    LinkedIn: Glenn McConell https://www.linkedin.com/in/glenn-mcconell-83475460
    ResearchGate: Glenn McConell
    Email: [email protected]
    Subscribe to Inside exercise:
    Spotify: shorturl.at/tyGHL
    Apple Podcasts: shorturl.at/oFQRU
    YouTube: https://www.youtube.com/@insideexercise
    Anchor: https://anchor.fm/insideexercise
    Google Podcasts: shorturl.at/bfhHI
    Anchor: https://anchor.fm/insideexercise
    Podcast Addict: https://podcastaddict.com/podcast/4025218
    Not medical advice

    1 hr 55 min
  • #75 - Physiology of exercise in extreme environments: sex as a biological variable with Dr Nisha Charkoudian

    Dr Glenn McConell chats with Associate Professor Nisha Charkoudian from the US Army Research Institute of Environmental Medicine, Natick, Massachusetts, USA. She is an expert on the effects of extreme environments on exercise capacity. We talked about dehydration, electrolytes, effects of humid vs dry environments etc. We also discussed the importance of considering sex as a biological variable. This included including both sexes in studies even if underpowered to examine both. We then discussed the importance of conducting more studies on thermoregulation and blood pressure with aging. A very interesting chat.
    0:00. Introduction
    3:45. What is the definition of extreme environments?
    5:05. Who gets the hottest/has the most issues with heat?
    9:00. Effects of humid vs dry environments and hydration
    12:05. Should drink until urine is clear before a race?
    16:10. Should people worry about electrolytes?
    20:44. Sex as a biological variable. Women not more fragile etc
    23:30. Sex differences in heat acclimation
    25:20. No difference in risk of heat stroke between the sexes
    25:50. If no difference then just study one sex?
    27:38. Need to include women even if small sample
    32:34. Even if underpowered it’s ok to include both sexes
    40:20. Gender vs sex, binary vs non binary etc
    42:00. Women and blood flow/blood pressure/heat etc
    49:05. Body surface area and heat/cold
    52:01. Progesterone and body core temperature
    54:25. Aging and thermogerulation
    57:35. Takeaway messages
    1:00:44. Outro
    Inside Exercise brings to you the who's who of research in exercise metabolism, exercise physiology and exercise’s effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all.
    The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University.
    He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (https://link.springer.com/book/10.1007/978-3-030-94305-9).
    Connect with Inside Exercise and Glenn McConell at:
    Twitter: @Inside_exercise and @GlennMcConell1
    Instagram: insideexercise
    Facebook: Glenn McConell
    LinkedIn: Glenn McConell https://www.linkedin.com/in/glenn-mcconell-83475460
    ResearchGate: Glenn McConell
    Email: [email protected]
    Subscribe to Inside exercise:
    Spotify: shorturl.at/tyGHL
    Apple Podcasts: shorturl.at/oFQRU
    YouTube: https://www.youtube.com/@insideexercise
    Anchor: https://anchor.fm/insideexercise
    Google Podcasts: shorturl.at/bfhHI
    Anchor: https://anchor.fm/insideexercise
    Podcast Addict: https://podcastaddict.com/podcast/4025218
    Not medical advice

    1 hr 1 min
  • #74- Are beta2-agonists just asthma treatments or also performance enhancers? With Dr Morten Hostrup

    Dr Glenn McConell chats with Associate Professor from the University of Copenhagen, Denmark. He is an expert on the effect of beta2-agonist asthma bronchodilator medications (like Ventolin) on muscle and exercise performance. We talked about what is asthma/exercise induced bronchoconstriction, can you train your lungs?, the increased prevalence of asthma in endurance athletes, can asthma limit aerobic capacity, what are beta2-agonists?, acute and chronic effects of beta2-agonists on muscle mass, sprinting, strength and endurance, side effects of beta2-agonists and negative effects of beta2 agonists on endurance exercise. Beta2-agonists should only be used for asthma treatment. A very interesting chat. Twitter: @morten_hostrup.
    0:00. Introduction
    2:12. Morten’s very good excuse for postponing coming on
    5:15. What is asthma?
    6:50. Lungs in endurance athletes vs general population
    1:11:15. Increased asthma in endurance athletes
    13:58. Why more asthma in endurance athletes?
    17:20. Asthmatic athletes can be very successful
    19:50. VO2 max etc not effected by asthma
    24:18. Beta2-agonists can have negative effects on VO2 max
    26:30. Sympathetic/parasympathetic nervous systems
    29:06. What are Beta2-agonists and what do they do?
    31:30. Inhaled medications can get into the blood
    32:40. Different beta2-agonists
    35:23. Legitimate and illegitimate use of beta2-agonists
    40:30. Up to 90% of some cohorts take beta2-agonists
    42:30. Legal limits of beta2-agonists use
    43:40. Acute effects on muscle mass/ sprinting
    49:02. Mechanisms of effect on muscle
    53:13. How limit misuse?
    56:39. Chronic effects on muscle
    1:02:50. Hypertrophy from chronic beta2-agonists
    1:06:15. Prevalence of use in body builders
    1:07:40. Combined use of drugs in body builders
    1:10:00. Effect of combining with corticosteroids
    1:16:30. Normal doses have small effects on muscle
    1:17:10. Side effects
    1:21:00. Mechanisms of chronic beta2-agonists on muscle
    1:23:30. Muscle mass and insulin sensitivity
    1:27:22. Potency vs anabolic steroids etc
    1:29:35. Competition with beta blockers
    1:31:55. Cycling on and off beta2-agonists?
    1:32:35. Effects during exercise
    1:37:04. Anti-diabetic effects?
    1:38:15. Maintains muscle mass during weight loss
    1:39:30. Alzheimer’s and Parkinson’s disease
    1:40:55. Sex differences
    1:42:40. Age effects
    1:43:40. Does exercise training affect beta2 receptors?
    1:44:45. Negative effects on endurance exercise
    1:47:02. Increase muscle mass but not so much strength
    1:50:20. Controversies in the field
    1:52:30. Some claim beta2 agonists have no systemic effects
    1:58:00. Takeaway messages
    1:59:28. Outro

    Inside Exercise brings to you the who's who of research in exercise metabolism, exercise physiology and exercise’s effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all.
    The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University.
    He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (https://link.springer.com/book/10.1007/978-3-030-94305-9).
    Connect with Inside Exercise and Glenn McConell at:
    Twitter: @Inside_exercise and @GlennMcConell1
    Instagram: insideexercise
    Facebook: Glenn McConell
    LinkedIn: Glenn McConell https://www.linkedin.com/in/glenn-mcconell-83475460
    ResearchGate: Glenn McConell
    Email: [email protected]
    Subscribe to Inside exercise:
    Spotify: shorturl.at/tyGHL
    Apple Podcasts: shorturl.at/oFQRU
    YouTube: https://www.youtube.com/@insideexercise
    Anchor: https://anchor.fm/insideexercise
    Google Podcasts: shorturl.at/bfhHI
    Anchor: https://anchor.fm/insideexercise
    Podcast Addict: https://podcastaddict.com/podcast/4025218
    Not medical advice

    2 hr
  • #73 - Protein and muscle adaptations to loading and unloading with Professor Luc van Loon

    Dr Glenn McConell chats with Professor Luc van Loon from Maastricht University, The Netherlands. He is an expert with a wealth of knowledge on the role of physical activity/exercise and nutrition on muscle adaptation. A lot of his research focuses on protein and protein synthesis. He applies these studies to young healthy individuals, the aged and also has conducted important experiments on people in ICU. He makes it clear that most people, especially athletes, get enough protein in their diet so do not need to take supplements. Are there really non responders to exercise training? Anabolic resistance with aging is due to inactivity. Lots more. A very interesting chat.
    0:00. Introduction
    2:09. How Luc got into exercise research
    6:30. Moving into protein metabolism
    8:05. Using tracers to determine exercise metabolism
    11:40. How much protein do we need?
    16:35. Protein rich foods after exercise
    17:00. Generally don’t need supplements.
    18:20. Food vs supplements
    19:35. Effects of lower protein intakes
    23:50. Protein turnover in some organs higher than muscle
    28:00. Optimal protein intake/additional protein
    31:00. Athletes eat more so likely don’t need extra protein
    34:00. Exercise increases protein uptake for up to 48hr
    38:40. Increased protein synthesis doesn’t necessarily mean increased muscle mass
    42:37. Protein needs of strength vs endurance athletes
    44:45. “Protein supplementation” just means above normal diet
    49:30. Misunderstanding of research findings re translation
    50:43. Need consistent exercise to adapt
    56:43. Plant vs animal proteins: not a big issue
    1:03:40. We are recycling a lot of protein each day
    1:05:33. Exercise stimulus and individual variations of adaptations
    1:07:50. Are there really non responders to exercise training?
    1:11:09. Re-sensitizing muscle by changing the stimulus
    1:12:42. Anabolic resistance with age (due to inactivity?)
    1:16:50. Muscle loss with aging largely episodes of bed rest etc
    1:20:17. Electrical stimulation prevents muscle loss in ICU
    1:25:06. Normal response to resistance training with aging
    1:34:22. Protein use during exercise
    1:36:16. Protein synthesis occurs during exercise
    1:40:00. Protein requirements when injuries/in bed
    1:41:40. Does collagen supplementation have benefits?
    1:45:20. What further studies would Luc like to do?
    1:46:10. Personalized diet and exercise prescription
    1:47:09. Sex differences, men and women studies etc
    1:49:22. Takeaway messages
    1:50:28. What’s most important, diet or physical activity?
    1:51:55. Outro
    Inside Exercise brings to you the who's who of research in exercise metabolism, exercise physiology and exercise’s effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all.
    The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University.
    He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (https://link.springer.com/book/10.1007/978-3-030-94305-9).
    Connect with Inside Exercise and Glenn McConell at:
    Twitter: @Inside_exercise and @GlennMcConell1
    Instagram: insideexercise
    Facebook: Glenn McConell
    LinkedIn: Glenn McConell https://www.linkedin.com/in/glenn-mcconell-83475460
    ResearchGate: Glenn McConell
    Subscribe to Inside exercise:
    Spotify: shorturl.at/tyGHL
    Apple Podcasts: shorturl.at/oFQRU
    YouTube: https://www.youtube.com/@insideexercise
    Anchor: https://anchor.fm/insideexercise
    Google Podcasts: shorturl.at/bfhHI
    Anchor: https://anchor.fm/insideexercise
    Podcast Addict: https://podcastaddict.com/podcast/4025218
    Not medical advice

    1 hr 53 min
  • #72 - Tendons: from exercise adaptation to injury and rehabilitation, with Professor Michael Kjær

    Dr Glenn McConell chats with Professor Michael Kjær from the Department of Clinical Medicine, Bispebjerg Hospital, the University of Copenhagen, Denmark. He is an expert on tendons and exercise. We chatted about muscle vs musculotendinous junction vs tendon, what structures get injured and why, tendon injuries: mechanisms, prevention, treatment, acute vs chronic/overuse tendon injuries, best to rest or exercise injured tendons?, whether diet, supplements or medicine can assist recovery from tendon injuries etc. We also discussed his earlier work on glucose metabolism during exercise. A very interesting chat.
    0:00. Introduction
    2:05. How Michael got into exercise research
    5:54. His glucose metabolism during exercise work
    11:20. Redundancy in physiology, animal vs human work
    13:45. His muscle work and movement into injury research etc
    16:20. His move into connective tissue/tendon research
    21:30. Taking a risk to move fields/finding collaborations
    23:30. Muscle vs musculotendinous junction vs tendon
    28:00. Why get muscle/tendon injuries
    31:45. Tendon stretches as muscle shortens
    33:05. Age and body weight effects on injury
    34:15. Interface between muscle and tendon
    37:10. Tendon overuse injuries
    41:40. What determines if injury occurs in muscle vs tendon
    44:20. Why tendon can feel better once warms up
    46:45. Water accumulation vs structural changes
    48:00. No evidence that exercising painful tendon increases rupture
    50:00. Development and turnover of tendons/circadian rhythm
    52:08. Blood vessels and flow in tendons at rest/during exercise
    55:00. Strength training and tendon size
    56:20. Best not to rest if injured tendon
    57:45. Need controlled loading of tendon to recover
    1:00:00. Supplements/surgery for tendon recovery?
    1:01:00. Can a tendon biopsy activate tendon repair?
    1:02:40. 3 x 10 reps per week may be enough
    1:04:50. Don’t need to focus on eccentric phase
    1:06:35. Need good shoes etc to reduce injury?
    1:09:00. What is a tendonopathy?
    1:10:00. RICE, anti inflammatories and cortisol shots etc?
    1:13:01. Collagen etc supplements and tendons
    1:15:10. Prevention of tendon injuries
    1:17:40. Signs of tendon injury
    1:20:20. Does warm up/ stretching reduce injury?
    1:23:18. Can a tendon torn off the bone recover without surgery?
    1:24:10. Age and tendon stiffness: inactivity vs age
    1:25:50. Fast twitch fibers and injuries
    1:27:35. Type 2 diabetes and tendon problems
    1:28:35. Can predict tendon injuries?
    1:29:18. Do tendons secrete molecules during exercise?
    1:30:00. Circadian rhythm, sleep and tendons
    1:32:17. Takeaway messages
    1:33:28. Outro
    Inside Exercise brings to you the who's who of research in exercise metabolism, exercise physiology and exercise’s effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all.
    The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University.
    He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (https://link.springer.com/book/10.1007/978-3-030-94305-9).
    Connect with Inside Exercise and Glenn McConell at:
    Twitter: @Inside_exercise and @GlennMcConell1
    Instagram: insideexercise
    Facebook: Glenn McConell
    LinkedIn: Glenn McConell https://www.linkedin.com/in/glenn-mcconell-83475460
    ResearchGate: Glenn McConell
    Email: [email protected]
    Subscribe to Inside exercise:
    Spotify: shorturl.at/tyGHL
    Apple Podcasts: shorturl.at/oFQRU
    YouTube: https://www.youtube.com/@insideexercise
    Anchor: https://anchor.fm/insideexercise
    Google Podcasts: shorturl.at/bfhHI
    Anchor: https://anchor.fm/insideexercise
    Podcast Addict: https://podcastaddict.com/podcast/4025218
    Not medical advice

    1 hr 34 min
  • #71 - Aging, inactivity, atrophy and exercise with Professor Sue Bodine

    Dr Glenn McConell chats with Professor Sue Bodine from the Oklahoma Medical Research
    Foundation, Oklahoma, USA. She is an expert on muscle, in particular muscle atrophy with inactivity/aging. We chatted about how with age muscle size is reduced and this is associated with a reduction in muscle fiber size and also a loss of fast muscle fibers. Resistance training (and perhaps intense endurance exercise) can attenuate the rate of muscle atrophy. We discussed how much muscle atrophy is due to age per se and how much is due to inactivity. Anabolic resistance, protein synthesis, the importance of strength for balance etc. A very interesting chat.
    0:00. Introduction + how Sue got into exercise research
    5:25. What determines muscle strength
    7:20. What age do we start losing muscle mass and strength?
    8:40. Muscle atrophy and loss of fast muscle fibers
    13:10. Can exercise training reduce the loss of fast fibers with age?
    17:50. How muscle of muscle atrophy with age in inactivity?
    19:20. Anabolic resistance with age
    20:40. A role of hormones in muscle atrophy with age?
    22:30. Protein synthesis and turnover in muscle with aging
    26:46. How much exercise is needed to attenuate muscle atrophy?
    30:30. Aging vs inactivity vs immobilizing vs bed rest etc
    33:30. Importance of exercise after bed rest/immobilization
    37:27. Upper body atrophy in runners/cyclist etc
    39:55. Intense endurance exercise and slow muscle fiber size
    43:00. Need to actually work out not just turn up
    44:42. Exercise prescription with aging
    47:05. Balance with age/inactivity
    48:45. Diet and muscle atrophy
    50:00. Need a stimulus (ex training) not eating more protein
    54:52. Disease processes and muscle atrophy
    58:10. Mechanisms playing a role in muscle atrophy/hypertrophy
    1:08:53. Don’t need to break down muscle to build muscle
    1:10:40. Determining muscle quality/specific tension
    13:02. Are slow fibers really weaker than fast fibers?
    1:17:22. Takeaway messages
    1:18:53. Can very old people still get stronger/hypertrophy?
    1:19:50. Do females really hypertrophy less?
    1:22:00. Outro
    Inside Exercise brings to you the who's who of research in exercise metabolism, exercise physiology and exercise’s effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all.
    The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University.
    He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (https://link.springer.com/book/10.1007/978-3-030-94305-9).
    Connect with Inside Exercise and Glenn McConell at:
    Twitter: @Inside_exercise and @GlennMcConell1
    Instagram: insideexercise
    Facebook: Glenn McConell
    LinkedIn: Glenn McConell https://www.linkedin.com/in/glenn-mcconell-83475460
    ResearchGate: Glenn McConell
    Email: [email protected]
    Subscribe to Inside exercise:
    Spotify: shorturl.at/tyGHL
    Apple Podcasts: shorturl.at/oFQRU
    YouTube: https://www.youtube.com/@insideexercise
    Anchor: https://anchor.fm/insideexercise
    Google Podcasts: shorturl.at/bfhHI
    Anchor: https://anchor.fm/insideexercise
    Podcast Addict: https://podcastaddict.com/podcast/4025218
    Not medical advice

    1 hr 23 min

About Inside Exercise

From the publisher's feed

Inside Exercise brings the absolute who's who of researchers in exercise physiology and metabolism and exercise’s effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all.

More shows like Inside Exercise

The Strength Running Podcast by Jason Fitzgerald

The Strength Running Podcast

1,341 Listeners

The Diary Of A CEO with Steven Bartlett by DOAC

The Diary Of A CEO with Steven Bartlett

8,325 Listeners

Huberman Lab by Scicomm Media

Huberman Lab

28,984 Listeners

The Rest Is Politics by Goalhanger

The Rest Is Politics

3,023 Listeners