Inside Exercise

By Glenn McConellHealth & Fitness Fitness

Inside Exercise episodes

June 13, 2023 #50 - Acute catabolic (yes, catabolic...) response of bone to exercise with Dr Wendy Kohrt
Dr Glenn McConell chats with Professor Wendy Kohrt from the University of Colorado Anschutz Medical Campus. She has an extremely strong track record of research on how exercise affects bone. She has changed her thinking of late after finding that acute exercise actually has a catabolic effect on bone even though overall, it can have beneficial effects. This is dependent on the actual exercise/sport undertaken and the duration. A very interesting chat.
0:00. Introduction/overview of Wendy’s exercise and research background
5:26. How Wendy got interested in bone/John Holloszy
8:48. Exercise, bone loss and NSAIDs
13:08. Cyclists have low bone density and possible mechanisms
18.44. Sweat calcium loss results in low bone density in cyclists?
23:54. Serum calcium decreases within 15 min of cycling exercise
25:58. Parathyroid hormone increases during cycling exercise
30:20. Calcium clamp during cycling exercise to prevent reduction in serum calcium
33:40. Bone breakdown during cycling exercise that continues for a period after exercise
36:15. What about walking/running?
38:50. Calcium clamp to prevent reductions in serum calcium prevents more of bone breakdown
40:15. When serum calcium decreases, where is the calcium going? Muscle mitochondria?
43:38. Calcium tracer experiments to determine turnover etc during exercise
47:00. Calcium supplementation before exercise?
49:20. Serum calcium levels during running exercise
51:37. So is exercise bad for bone? Paradoxical effects of Parathyroid hormone on bone
54:15. Pharmacological transient increases in parathyroid hormone stimulates bone formation
56:52. Is exercise good for bone health?
59:30. Wendy's current studies
1:03:06. Other effects of bone markers on metabolism etc?
1:05:10. Peak bone mass in late teens/early 20's very important / aging and bone
1:08:28. Calcium and Vit D supplementation and bone
1:11:24. Bone mass in people who have undertaken different types of sports
1:15:26. Should people supplement with calcium before exercise?
1:17:04. Wendy's involvement with the MoTrPAC NIH common fund initiative
1:25:37. Takeaway messages
1:27:30. Serum calcium changes during exercise and the heart?
1:29:04. Outro (9 seconds)
Inside Exercise brings to you the who's who of research in exercise metabolism, exercise physiology and exercise’s effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all.
The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University.
He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (https://link.springer.com/book/10.1007/978-3-030-94305-9).
Connect with Inside Exercise and Glenn McConell at:
Twitter: @Inside_exercise and @GlennMcConell1
Instagram: insideexercise
Facebook: Glenn McConell
LinkedIn: Glenn McConell https://www.linkedin.com/in/glenn-mcconell-83475460
ResearchGate: Glenn McConell
Email: [email protected]
Subscribe to Inside exercise:
Spotify: shorturl.at/tyGHL
Apple Podcasts: shorturl.at/oFQRU
YouTube: https://www.youtube.com/@insideexercise
Anchor: https://anchor.fm/insideexercise
Google Podcasts: shorturl.at/bfhHI
Anchor: https://anchor.fm/insideexercise
Podcast Addict: https://podcastaddict.com/podcast/4025218
Not medical advice
1 hr 30 min
June 08, 2023 #49 - Remarkable benefits of exercise in myopathy patients with Dr Mark Tarnopolsky
Dr Glenn McConell chats with Professor Mark Tarnopolsky from McMaster University in Canada. Mark has done pioneering studies in many areas including sex differences and exercise, HITT training and creatine supplementation. Today we focus on his remarkable work with muscle myopathies. Exercise can be beneficial in all muscle myopathies in regards to function and/or healthspan and/or lifespan. The type of exercise will differ depending on the myopathy: endurance, resistance, or both.
0:00. Introduction and overview of Mark’s exercise, clinical and research
4:45. McMaster University: Stu Phillips, Marty Gibala and Mark
6:30. His sex differences and exercise research
8:06. Exosomes re drug delivery and exercise
15:48. Types of muscle myopathies
19:39. Exercise can improve McArdles disease
24:29. Weight training, creatine and McArdles disease
28:20. Exercise and glycoytic defects, glucose ingestion/fasting
30:53. Creatine phosphate
34:50. Rhabdomyolysis
39:53. Mark’s very impressive sporting background and lab numbers
41:45. Mark’s cardiac ablations
42:48. The heart and VO2 max etc
43:49. Mitochondrial disease and exercise/RER
48:30. Ex training increases VO2 max in mitochondrial disease
51:00. Most common mitochondrial diseases
53:20. How does exercise improve exercise in mitochondrial diseases
55:00. Muscle affected in different genetic deficits
57:26. Neuromuscular junction with Dr Tarnopolsky on YouTube
58:17. Exercise beneficial with pretty much every muscle disease
58:40. Exercise improves strength in Inclusion body myopathy
58:50. Exercise improves function etc in muscular dystrophy
59:5 Pompe disease. Exercise better than $1million/yr treatment
1:01:18. Tends to be focus on pharma despite exercise being better
1:03:35. Duchenne muscular dystrophy, exercise and life expectancy
1:09.02. Resistance vs strength vs both in muscle defects
1:11:38. Different resistance training tactics in mitochondrial patients
1:13:02. Creatine and other supplements in muscle defects
1:16:29. Study designs, funding,patents etc
1:18:07. Do people who don’t have muscle myopathies need supplements?
1:19:11. Disclosure: Founder and CEO of the Exerkine Company
1:21:40. “Exercise the best supplement”
1:23:59. Exokines within exosomes not that useful so far
1:28:24. Take away messages
1:31:42. Mark’s running ability/injuries as age etc.
1:33:57. Mark’s injuries/diet/supplements
1:36:54. Outro (9 seconds)
Inside Exercise brings to you the who's who of research in exercise metabolism, exercise physiology and exercise’s effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all.
The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University.
He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (https://link.springer.com/book/10.1007/978-3-030-94305-9).
Connect with Inside Exercise and Glenn McConell at:
Twitter: @Inside_exercise and @GlennMcConell1
Instagram: insideexercise
Facebook: Glenn McConell
LinkedIn: Glenn McConell https://www.linkedin.com/in/glenn-mcconell-83475460
ResearchGate: Glenn McConell
Email: [email protected]
Subscribe to Inside exercise:
Spotify: shorturl.at/tyGHL
Apple Podcasts: shorturl.at/oFQRU
YouTube: https://www.youtube.com/@insideexercise
Anchor: https://anchor.fm/insideexercise
Google Podcasts: shorturl.at/bfhHI
Anchor: https://anchor.fm/insideexercise
Podcast Addict: https://podcastaddict.com/podcast/4025218
Not medical advice.
Disclosure: Prof Tarnopolsky is the Founder and CEO of the Exerkine Company.
1 hr 38 min
May 29, 2023 #48 - Dr David Costill: Legend of exercise physiology and human performance
Dr Glenn McConell chats with Emeritus Professor David “Doc” Costill who is an absolute legend of exercise physiology and human performance. He was Founder and Director of the Human Performance Laboratory at Ball State University in Muncie, Indiana, USA. He made the lab one of the top labs in the world and has a remarkable track record. He supervised the who’s who of exercise physiology research including 7 people (8 including me) who have been on the Inside exercise podcast.
0:00. Introduction, Dave’s the reason I started this podcast
3:54. Frank Pyke
5:37. Many people on the podcast were supervised by Dave
6:00. Dave a fantastic supervisor
6:20. How Dave started his career. Ohio State.
10:23. 1966. Cortland College. Coaching running coach etc. Bob Fitts
16:18. Dave’s incredible swimming ability
18:15. Early running/ running groups/running research
24:12. PhD: essentially supervised himself
27:43. Worked crazy long hours/ Ball State University
36:48. Temperature regulation and running research
37:53. Heart disease and exercise research
38:35. Sports nutrition research
39:58. Caffeine and exercise research
43:30. He exemplifies the golden age of exercise physiology
44:10. Dissemination of information in the lay press/Jim Fixx
47:30. Endowed Chair/applying for grants. 48:20. D. Bruce Dill and the Harvard Fatigue Lab
51:55. David Costill showed Bengt Saltin soleus biopsies
57:35. Phil Gollnick
58:50. Dave’s sense of humor/treats people as equals
1:00:50. Awesome morning routine with Dave / Bill Fink
1:05:00. His untimed exactly 10 min naps
1:06:40. Dehydration, temp regulation and ex perf
1:07:16. Muscle glycogen and exercise (running vs cycling)
1:08:50. Eccentric exercise
1:11:50. Dave Pearson
1:12:48. His swimming research/tapering and his swimming career
1:33:17. He found his swimming times really dropped off after 80
1:37:00. His health
1:39:15. Bicarbonate supplementation and exercise performance
1:42:48. Bob Fitts and Dave looking at single muscle fibers
1:46:00. Space research
1:48:03. Bear hibernation research
1:52:58. Enjoyed being in the lab, “like being in a candy store”
1:56:29. Exercise physiology textbooks vs online learning
1:57:40. Dave’s treadmill VO2 max at 87 years old
1:59:02. Dave’s swimming and running textbooks
2:01:15. Dave’s hobbies: pilot, restoring cars, building planes!
2:09:55. Funny Awards Dave gave out
2:12:00. Outro (9 seconds)
Inside Exercise brings to you the who's who of research in exercise metabolism, exercise physiology and exercise’s effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all.
The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University.
He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (https://link.springer.com/book/10.1007/978-3-030-94305-9).
Connect with Inside Exercise and Glenn McConell at:
Twitter: @Inside_exercise and @GlennMcConell1
Instagram: insideexercise
Facebook: Glenn McConell
LinkedIn: Glenn McConell https://www.linkedin.com/in/glenn-mcconell-83475460
ResearchGate: Glenn McConell
Email: [email protected]
Subscribe to Inside exercise:
Spotify: shorturl.at/tyGHL
Apple Podcasts: shorturl.at/oFQRU
YouTube: https://www.youtube.com/@insideexercise
Anchor: https://anchor.fm/insideexercise
Google Podcasts: shorturl.at/bfhHI
Anchor: https://anchor.fm/insideexercise
Podcast Addict: https://podcastaddict.com/podcast/4025218
Not medical advice
2 hr 13 min
May 21, 2023 #47 - Speed-duration relationship across the animal kingdom with Dr Mark Burnley
Dr Glenn McConell chats with Dr Mark Burnley from the Loughborough University in England. He is an expert on critical power (cycling) and critical speed (running). We compared and contrasted the speed duration relationship across the animal kingdom. Mark is an absolute wealth of knowledge on exercise intensity domains and critical power etc and comparative exercise physiology. Critical power is essentially one’s aerobic capacity and W’ is essentially one’s work capacity. Twitter: @DrMarkBurnley
0:00. Introduction and how Mark’s entry into research
6:12. Exercise intensity domains/ Critical power
10:02. Single out exercise to determine critical power
11:55. Marks students, supervisors, collaborators in the area etc
14:55. Critical power and W’ (the work capacity above critical power)
18:15. Lactate threshold and critical power
23:42. Isometric exercise, resistance exercise and critical power
26:50. Is W’ really all only anaerobic work capacity?
28:36. Maximum accumulated oxygen deficit
29:56. Practical use of critical power/ W’ for training/racing
31:55. Critical speed/pacing
33:50. Zones of training and critical power
37:35. Mark feels that with ex training all roads lead to Rome/Tokyo
38:15. Zone 2 confusion/evidence/lack of evidence etc
41:35. Animal athletes/critical power in animals
53:22. Dogs are too smart to do proper critical power measures
57:20. Desert Iguanas critical power
59:21. Crabs critical power
1:02:00. How compare critical speeds across the animal kingdom
1:04:46. Lungless salamanders critical power
1:06:37. Fish and birds critical power
1:16:35. Fibre type/capillaries/muscle mass and critical power
1:25:30. Humans are below average athletically
1:27:30. Migratory birds energy expenditure etc
1:31:40. Monty python
1:34:42. The speed duration curve shape tends to be similar across species
1:35:03. Crabs and humans have similar critical speed relationships!
1:36:00. Recovery and critical speed. W’ balance
1:39:02. Unthinking lactate use re Best practice for LT determination
1:44:27. Takeaway messages
1:47:10. Zones and training
1:51:10. With ex training all roads lead to Rome/Tokyo
1:52:21. Outro (9 seconds)
Inside Exercise brings to you the who's who of research in exercise metabolism, exercise physiology and exercise’s effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all.
The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University.
He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (https://link.springer.com/book/10.1007/978-3-030-94305-9).
Connect with Inside Exercise and Glenn McConell at:
Twitter: @Inside_exercise and @GlennMcConell1
Instagram: insideexercise
Facebook: Glenn McConell
LinkedIn: Glenn McConell https://www.linkedin.com/in/glenn-mcconell-83475460
ResearchGate: Glenn McConell
Email: [email protected]
Subscribe to Inside exercise:
Spotify: shorturl.at/tyGHL
Apple Podcasts: shorturl.at/oFQRU
YouTube: https://www.youtube.com/@insideexercise
Anchor: https://anchor.fm/insideexercise
Google Podcasts: shorturl.at/bfhHI
Anchor: https://anchor.fm/insideexercise
Podcast Addict: https://podcastaddict.com/podcast/4025218
Not medical advice
1 hr 53 min
May 14, 2023 #46 - What are we polarizing in polarized endurance training? Dr Stephen Seiler
Dr Glenn McConell chats with Professor Stephen Seiler from the University of Agder in Norway. He is American who started his career in USA before moving to Norway almost 30 years ago. He points out that most exercise training research is based around university semesters with mainly untrained to trained transitions which is very different to what athletes do. Stephen coined the term polarized training in 2004 and makes the argument that this is the best way to train and that most world class endurance athletes train this way. This discussion is interesting to compare and contrast with recent episodes with A/Prof Andrew Coggan and Prof Michael Joyner who tend to say all roads lead to Rome. Twitter: @StephenSeiler
0:00. Introduction and welcome
2:09. Stephen’s excellent sports science website from back in 1995/6
4:30. How Stephen got into exercise research
7:12. David Costill
8:23. Stephens early heart research in rats then move to Norway
11:37. His time at the University of Texas in Austin
13:50. Debates about the best ways to train for endurance
17:20. Ex training research is based around university semesters
21:45. Norway: “Threshold training to much pain due too little gain”
22:50. Stephen coined the term polarized training in 2004.
23:45. Most endurance athletes do most training below LT1
24:20. Three zone and five zone exercise training models
29:10. Pyramidal training
30:45. Sharpening/tapering before races (more polarized)
32:43. Exercise training: signal versus stress
39:30. Manipulating training frequency, duration and intensity
41:03.Overtraining: maximum heart rate (parasympathetic hypersensitivity) etc
48:13. People starting out, get them out the door and develop habit
53:20. Zones as VO2 max goes up
55:35. How know zones?, lactate?, HR, power (Andy Coggan), RPE, talking test
59:33. Hilly running/intervals, metallic taste in mouth, coughing
1:02:50. Do swimmers do polarized training though? David Costill
1:05:02. Polarized training. Approx 80/20 based on sessions, 90/10 based on time
1:08:30. Black hole intensity. Not really easy and not really hard
1:10;46. Threshold training pace, Importance of duration (intensity x duration). HRV
1:17:12. Agrees with Andy Coggans points that lactic acid does not inhibit fat oxidation
1:19:32. Zone 2 and Inigo San Milan
1:22:50. Mitochondrial biogenesis, AMPK and calcium. Intensity vs volume
1:27:48. Cardiovascular drift/ uncoupling
1:30:35. But don't most athletes do pyramidal training?
1:33:40. Race pace specificity
1:34:08. Isn't it logical that the larger the training volume the lower the average intensity?
1:38:40. Pro cyclists training averages only 65% of max HR
1:43:10. Lab evidence vs data from athletes Strava etc
1:44:25. Doing lots of threshold training causes stagnation/functional over reaching
1:48:06. Take the emotion / religion out re the importance of Zone 2. Importance of duration.
1:54:59. Outro (9 seconds)
Inside Exercise brings to you the who's who of research in exercise metabolism, exercise physiology and exercise’s effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all.
The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research.
Connect with Inside Exercise and Glenn McConell at:
Twitter: @Inside_exercise and @GlennMcConell1
Instagram: insideexercise
Facebook: Glenn McConell
LinkedIn: Glenn McConell https://www.linkedin.com/in/glenn-mcconell-83475460
ResearchGate: Glenn McConell
Email: [email protected]
Subscribe to Inside exercise:
Spotify: shorturl.at/tyGHL
Apple Podcasts: shorturl.at/oFQRU
YouTube: https://www.youtube.com/@insideexercise
Anchor: https://anchor.fm/insideexercise
Google Podcasts: shorturl.at/bfhHI
Anchor: https://anchor.fm/insideexercise
Podcast Addict: https://podcastaddict.com/podcast/4025218
Not medical advice

1 hr 56 min
May 06, 2023 #45 - From heat shock doc to kettlebells with Dr Pope Moseley
Dr Glenn McConell chats with Professor Pope Moseley from Arizona State University in the United States. Pope has a lung and critical care background. We spoke about his early heat shock protein work with Carl Gisolfi, a giant of research on exercise and the gut. Also heat, heat shock proteins, gut leak and heat stroke, exercise training and gut leak, heat shock proteins and autophagy, “Heat shock proteins are how cells think”, heat related illness is only a fraction of disease driven by heat. After a serious acute back injury requiring back surgery, Pope found Kettlebells to be very useful (we discussed the person who introduced kettlebells to the west, Pavel Tsatsouline).
0:00. Introduction and Pope’s running and medical background
4:49. Heat shock proteins and exercise (with Carl Gisolfi)
9:45. Exercise and the heat legend: John Sutton
12:14. Cognitive effects of heat exhaustion after exercise
13:56. John Sutton papers brilliant
14:40. Heat, heat shock proteins and gut leak
19:15. Exercise training makes the gut less leaky
21:10. Heat stroke can be due to gut barrier breakdown
22:44. Chris Leigh, exertional heat stroke and the gut
24:14. Bente Klarlund Pedersen and Bengt Saltin
28:47. Interactions between heat shock proteins and autophagy
32:40. Heat shock proteins as chaperones
34:00. Heat shock proteins, autophagy and exercise
36:46. Exercise, exercise training and heat shock protein
38:01. Heat related illness only a fraction of disease driven by heat
44:15. Can exercise reduce the likelihood of heat related illness?
47:02. Denmark and equality, health care access, tax etc
50:57. Pope’s back injury and emergency surgery
54:50. Introduction to Kettlebells and his certification etc
56:10. Kettlebells and Pavel Tsatsouline
58:55. Pavel Tsatsouline, interval training and stroke volume
1:04:05. Grip strength, getting up from the floor and posture
1:08:04. Pope’s kettlebell Instagram
1:10:18. Working on heat in Phoenix Arizona
1:11:40. Pope doing the Tactical strength challenge
1:13:56. Viruses take over heat shock proteins
1:17:45. Takeaway messages
1:18:18. Outro (9 secs)
Inside Exercise brings to you the who's who of research in exercise metabolism, exercise physiology and exercise’s effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all.
The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University.
He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (https://link.springer.com/book/10.1007/978-3-030-94305-9).
Connect with Inside Exercise and Glenn McConell at:
Twitter: @Inside_exercise and @GlennMcConell1
Instagram: insideexercise
Facebook: Glenn McConell
LinkedIn: Glenn McConell https://www.linkedin.com/in/glenn-mcconell-83475460
ResearchGate: Glenn McConell
Email: [email protected]
Subscribe to Inside exercise:
Spotify: shorturl.at/tyGHL
Apple Podcasts: shorturl.at/oFQRU
YouTube: https://www.youtube.com/@insideexercise
Anchor: https://anchor.fm/insideexercise
Google Podcasts: shorturl.at/bfhHI
Anchor: https://anchor.fm/insideexercise
Podcast Addict: https://podcastaddict.com/podcast/4025218
Not medical advice
1 hr 19 min
April 30, 2023 #44 - The science of sports injuries and how to prevent and treat them with Dr Kristian Thorborg
Dr Glenn McConell chats with Professor Kristian Thorborg from the University of Copenhagen in Denmark who also has s position at Lund University in Sweden. We spoke about the role of the placebo effect, sports injury prevention and especially the role of eccentric exercise, plyometrics, whether stretching reduces sports injuries, prehabilitation, exercise to avoid surgery, rehabilitation, is ice useful, effectiveness of adjunct treatments, start with the least aggressive approach etc. Twitter: @KThorborg

0:00. Introduction and Kristian’s background
8:15. Evidence base for physiotherapy/ physiotherapy is a profession
12:20. Physiotherapy treatments for injury pain
14:21. The placebo effect in physiotherapy treatment
17:31. Outcomes when treated by a doctor vs a physiotherapist
20:52. Sports injury prevention with eccentric exercise
22:57. Nordic hamstring exercise: Eccentric exercise
32:33: Copenhagen abductor exercise: Eccentric exercise
39:45. Load vs speed of contractions re injury prevention
41:30. Plyometrics
44:34. Why Lance Armstrong bounding for cycling.
45:23. Does stretching reduce sports injuries?
55:26. Prehabilitation useful to recovery from surgery?
58:29. Exercise to avoid surgery
1:01:47. Rehabilitation: how early? Individualized vs usual care?
1:12:32. Push through pain?
1:14:09. Does good rehab reduce reinjury?
1:15:52. RICE. Not a fan of ice after injury
1:19:33. What are the biggest risk factors for injury?
1:24:55. Effectiveness of adjunct treatments
1:31:50. Is massage effective?
1:32:50. Sham surgery as effective as surgery?
1:36:28. Start with the least aggressive approach
1:40:45. Takeaway messages
1:44:25. Outro (9 secs)
Inside Exercise brings to you the who's who of research in exercise metabolism, exercise physiology and exercise’s effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all.
The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University.
He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (https://link.springer.com/book/10.1007/978-3-030-94305-9).
Connect with Inside Exercise and Glenn McConell at:
Twitter: @Inside_exercise and @GlennMcConell1
Instagram: insideexercise
Facebook: Glenn McConell https://www.facebook.com/glenn.mcconell/
LinkedIn: Glenn McConell https://www.linkedin.com/in/glenn-mcconell-83475460
ResearchGate: Glenn McConell
Email: [email protected]
Subscribe to Inside exercise:
Spotify: shorturl.at/tyGHL
Apple Podcasts: shorturl.at/oFQRU
YouTube: https://www.youtube.com/@insideexercise
Anchor: https://anchor.fm/insideexercise
Google Podcasts: shorturl.at/bfhHI
Anchor: https://anchor.fm/insideexercise
Podcast Addict: https://podcastaddict.com/podcast/4025218
Not medical advice
1 hr 45 min
April 24, 2023 #43 - The importance of exercise in space with Dr Scott Trappe
Dr Glenn McConell chats with Professor Scott Trappe, Director of the Human performance laboratory at Ball State University, Indiana, USA. We spoke about the influence that Scott’s supervisor, the great David “Doc” Costill, has had on exercise physiology (long time Ball State HPL Director before Scott). We then discussed the negative effects of space on the human body and whether exercise can minimize these negative effects. In space slow muscle fibers atrophy more than fast fibers and there is a large shift to fast fiber types. Exercise attenuates this. A very interesting, relaxed, fun chat. @HPLBallState
0:00. Introduction etc
3:22. Ball State, David Costill and Scott’s background
10:30. Space research: Bob Fitts, David Costill and Scott.
14:50. Retesting champion runners 25 plus years later
19:16. Space flight experiments, biopsies in Russia etc
20:43. Effects of space on physiology, fluid shifts etc
27:08. Slow muscle fibers atrophy more than fast fibers
29:50. Integrated physiology
31:40. Lower body negative pressure/exercise in space
37:22. 6 months and longer in space: Moon, Mars
40:10. Biopsies within 6-8 hrs after get back from space!
44:22. Appetite in space
46:09. Exercise around 90 min/day in space
47:23. Exercise provides partial protection and less fibre type shifts
50:34. Bed rest studies
52:10. Bone loss / not much pharmacology in space
53:02. Less interfering effects on exercise responses in space
55:08. Fiber type shifting with inactivity/space/exercise
1:00:30. Hybrid muscle fiber cells. Myosin heavy chains
1:04:16. Time course of bone loss/recovery
1:06:14. Is exercise before space flights protective?
1:07:19. Space travel, exercise and insulin sensitivity
1:08:06. VO2 max and the heart after space travel
1:10:43. Space flight increases the velocity of muscle contraction
1:16:45. Medications in space
1:18:00. Eccentric loads in space
1:19:04. Huge multi lab NIH exercise research project: MoTrPAC
1:28:59. Takeaway messages
1:30:43. David Costill: 87 and still training like an athlete!
1:34:30. Scott’s exercise training and racing
1:37:37. Banter about dos and don’t in the lab
1:38:52. Glenn’s Copenhagen sabattical plans/trip to Indiana?
1:41:30. Outro (9 secs)
Inside Exercise brings to you the who's who of research in exercise metabolism, exercise physiology and exercise’s effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all.
The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University.
He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (https://link.springer.com/book/10.1007/978-3-030-94305-9).
Connect with Inside Exercise and Glenn McConell at:
Twitter: @Inside_exercise and @GlennMcConell1
Instagram: insideexercise
Facebook: Glenn McConell
LinkedIn: Glenn McConell https://www.linkedin.com/in/glenn-mcconell-83475460
ResearchGate: Glenn McConell
Email: [email protected]
Subscribe to Inside exercise:
Spotify: shorturl.at/tyGHL
Apple Podcasts: shorturl.at/oFQRU
YouTube: https://www.youtube.com/@insideexercise
Anchor: https://anchor.fm/insideexercise
Google Podcasts: shorturl.at/bfhHI
Anchor: https://anchor.fm/insideexercise
Podcast Addict: https://podcastaddict.com/podcast/4025218
Not medical advice
1 hr 42 min
April 17, 2023 #42 - Circadian rhythms, exercise and type 2 diabetes with Dr Juleen Zierath
Dr Glenn McConell chats with Professor Juleen Zierath who has had a remarkable background with current senior roles at both the Karolinska Institute in Sweden and the University of Copenhagen in Denmark. She was also previously the Chair of the Nobel Committee. We discuss the effects of circadian rhythms on: muscle insulin sensitivity, metabolic responses to exercise in T2D vs controls, exercise performance, metabolism in men vs women and integrative physiology. A very interesting chat. Twitter: @JuleenRZierath.
0:00. Introduction and Juleen’s academic and research background
7:39. Ball State University and David “Doc” Costill
9:40. What it’s like on the Nobel Prize committee
15:00. Circadian rhythms and physiology/metabolism/exercise
18:50. Metabolic flexibility, circadian biology and exercise
19:50. Central and peripheral clocks etc.
23:55. Jet lag and light/clocks
24:25. Different experimental models: Insects, mice and humans
27:53. Circadian misalignments in obesity and diabetes
29:02. Genetics + environment re obesity, insulin sensitivity
30:06. Circadian rhythms in muscle cells
32:40. Exercise: can it cure type 2 diabetes?
35:32. Genes matter
35:42. Shift work and insulin resistance / cancer
36:46. Hyperglycemia after morning not afternoon exercise (CGMs)
43:50. Mortality and the time of exercise
44:56. Effect of the time of day on exercise performance
46:18. Sex differences: exercise, inflammation and the genome
50:37. Controversies?: we don’t know enough/more to learn
53:43. Takeaway messages
56:09. Outro (9 secs)
Inside Exercise brings to you the who's who of research in exercise metabolism, exercise physiology and exercise’s effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all.
The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University.
He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (https://link.springer.com/book/10.1007/978-3-030-94305-9).
Connect with Inside Exercise and Glenn McConell at:
Twitter: @Inside_exercise and @GlennMcConell1
Instagram: insideexercise
Facebook: Glenn McConell
LinkedIn: Glenn McConell https://www.linkedin.com/in/glenn-mcconell-83475460
ResearchGate: Glenn McConell
Email: [email protected]
Subscribe to Inside exercise:
Spotify: shorturl.at/tyGHL
Apple Podcasts: shorturl.at/oFQRU
YouTube: https://www.youtube.com/@insideexercise
Anchor: https://anchor.fm/insideexercise
Google Podcasts: shorturl.at/bfhHI
Anchor: https://anchor.fm/insideexercise
Podcast Addict: https://podcastaddict.com/podcast/4025218
Not medical advice
57 min
April 09, 2023 #41 - Zone 2 training: why all the talk? With Dr Andrew Coggan
Dr Glenn McConell chats for a second time with Associate Professor Andrew Coggan from Indiana University, Purdue University, Indianapolis (IUPUI), USA. Andy was an elite time trial cyclist who has a very impressive research track record. He also wrote the first book on training and racing using power (training levels). As was the case last week with Michael Joyner, Andy makes the case that different types of training can result in similar results (and there’s nothing special about zone 2). “Nothing magic about training at a particular intensity”. Andy was the first guest on Inside exercise in June 2022 talking about Nitrate and exercise.
0:00. Introduction and Andy’s cycling and research background
5:07. Andy’s cycling TTs and power based training
7:56. Andy’s early aerodynamic bike and aero positioning
10:56. His decision to develop cycling power levels
15:50. Wrote the first book on training and racing with power
17:00. Muscular metabolic fitness/lactate threshold
21:10. Onset of blood lactate accumulation (OBLA)
22:47. Little use having a one off lactate threshold test
23:55. Best predictor of performance is performance itself
24:25. Critical power / W’. Exercise intensity duration relationship
28:15. Zone based system around critical power
29:20. Training levels based on functional threshold power (FTP)
31:27. What is Zone 2? /long slow distance etc.
35:30. Lactate thresholds (LT1 and LT2)/continuum
37:55. Lactate threshold vs ventilation threshold
38:52. Don’t need to burn fat during ex to optimize fat use adaptations
41:07. Exercise intensity and fat use
43:45. What’s the best training program?
44:29. Same increases in ability to burn fat with HIIT
45:16. Lactate doesn’t inhibit fat use during exercise
51:40. Andy questions some interpretations of San Millan
53:10. Cardiovascular drift /aerobic decoupling
58:20. What to do if your performance plateaus
59:40. Exercise training programs: All roads lead to Rome
1:02:19. Specificity, overload, reversibility and different sports
1:04:34. Exercise training zones and intensity/duration
1:08:00. Physiological responses occur on a continuum
1:08:55. Quasi metabolic steady state
1:12:35. Wahoo 4 dimension power: “FTP is dead”
1:14:18. Takeaway messages/ the need for Inside exercise
1:17:32. Do people do zone 2 partly because it’s easy?
1:21:12. VO2 max does not change over a season
1:21:58. Demands of the event/characteristics of the athlete
1:23:57. Exercising and health (effects on the heart)
1:27:56. Outro (9 secs)
Inside Exercise brings to you the who's who of research in exercise metabolism, exercise physiology and exercise’s effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all.
The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University.
He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (https://link.springer.com/book/10.1007/978-3-030-94305-9).
Connect with Inside Exercise and Glenn McConell at:
Twitter: @Inside_exercise and @GlennMcConell1
Instagram: insideexercise
Facebook: Glenn McConell
LinkedIn: Glenn McConell https://www.linkedin.com/in/glenn-mcconell-83475460
ResearchGate: Glenn McConell
Email: [email protected]
Subscribe to Inside exercise:
Spotify: shorturl.at/tyGHL
Apple Podcasts: shorturl.at/oFQRU
YouTube: https://www.youtube.com/@insideexercise
Anchor: https://anchor.fm/insideexercise
Google Podcasts: shorturl.at/bfhHI
Anchor: https://anchor.fm/insideexercise
Podcast Addict: https://podcastaddict.com/podcast/4025218
Not medical advice
1 hr 29 min

About Inside Exercise

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Inside Exercise brings the absolute who's who of researchers in exercise physiology and metabolism and exercise’s effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all.