CAR-T immunotherapy- an amazing advance in oncology with high rates of remission, but most patients have complications. In this podcast we describe the science of CAR-T, physiologic timeline, and imaging features of adverse events which are common. All radiologists should be aware in order to better help our patients with cancer. Also, CNS Lupus- increasing in prevalence and still with high mortality. Learn more about the myriad imaging findings associated with this illness. Imaging Primer on Chimeric Antigen Receptor T-Cell Therapy for Radiologists. de Groot et al. RadioGraphics 2022; 42:176–194. Central Nervous System Systemic Lupus Erythematosus: Pathophysiologic, Clinical, and Imaging Features. Ota et al. RadioGraphics 2022; 42:212–232.