How does high physical activity level impact risk of incident carotid plaque components? Dr. Luosiyuan Zuo reported his research on how high physical activity level impacted the risk at ESC Congress 2024 and further discussed this topic based on the abstract for the ESC Congress 2024. Moderated by Dr. Zhangling Chen.

This issue features the first ever JACC: CardioOncology Expert Panel, providing consensus guidance and identifying the gaps in evidence in the cardiovascular care of our cancer patients. This is the first of a 3-part series focused on advancing evidence-based cardiovascular care prior to, during and after cancer therapy. Additionally, in this issue, we feature a number of high-impact state of the reviews, original research manuscripts and viewpoints.

In this episode of the JACC: CardioOncology Podcast, Antonio Cannata discusses the PROACT clinical trial, which investigated the effectiveness of enalapril in preventing cardiac damage in breast cancer and lymphoma patients undergoing anthracycline therapy. Despite neutral results, the conversation delves into the challenges of defining myocardial injury and emphasizes the need for improved risk stratification and innovative trial designs in future research.

In this episode, Brian Halliday discusses a Korean study examining the outcomes of patients with cancer therapeutics-related cardiac dysfunction after withdrawing cardioprotective therapy. He highlights that while patients with an ejection fraction between 45 and 55% fared similarly regardless of therapy continuation, those with an ejection fraction below 45% experienced worse outcomes when they withdrew treatment, underscoring the need for further randomized trials to refine therapeutic approaches.

In this episode, Dr. Sonia Shah explores a study from Australian researchers that evaluates the effectiveness of a polygenic risk score in predicting heart failure among cancer survivors. While the score enhanced prediction compared to age and sex alone, it did not significantly outperform existing modifiable risk factors, highlighting the need for more comprehensive models that account for unique risks faced by cancer patients.

In this episode, Brian Joyce discusses a groundbreaking study that examines the link between DNA methylation and the incidence of cardiovascular disease and cancer across three major cohorts. The research identifies shared epigenetic signatures associated with both diseases, highlighting the need for further investigation into their functional implications and potential clinical applications in diverse populations.

In this episode, Dr. Tochi Okwuosa discusses a pivotal study examining the association between the Life Essential 8 cardiovascular health score and the incidence of cardiovascular disease in women with breast cancer. The research, which followed over 7,000 participants, found that higher scores correlated with significantly lower rates of cardiovascular events, underscoring the importance of cardiovascular health even in cancer patients and highlighting the need for future studies in more diverse populations.

In this episode, Dr. Josh Mitchell reviews a significant study that explores the links between physical health markers, such as waist circumference and hand grip strength, and cardiovascular outcomes in men with prostate cancer undergoing androgen deprivation therapy. The findings indicate that increased waist circumference and decreased grip strength are associated with higher cardiovascular event risks, highlighting the need for targeted interventions like exercise in these patients and emphasizing the importance of further research in diverse populations.

In this episode, Efstratios Koutroumpakis discusses a critical study on autonomic dysfunction among adult survivors of childhood cancer, highlighting its prevalence and functional significance compared to community controls. The research underscores the complex etiologies of autonomic dysfunction linked to cancer treatments and stresses the importance of early detection and standardized testing to improve cardiovascular health and quality of life in this growing survivor population.

Emile Daoud, MD, Associate Editor of JACC: Clinical Electrophysiology discusses a recently published original research