JACC Specialty Journals

Commentary by Dr. Ching-wei Lee.

Commentary by Dr. Panteleimon Papakonstantinou.

Commentary by Dr. Timothy Ka-chun UN.

In this episode of the JACC: Clinical Electrophysiology podcast, Executive Editor Emile Daoud discusses the primary analysis of the HEAL‑LAA study. The paper by Oluseun Alli, et al, evaluates real‑world outcomes with a next‑generation, fluoropolymer‑coated left atrial appendage occlusion device. In 500 patients across 32 U.S. centers, the study demonstrated excellent early device sealing, no significant peri‑device leaks, and favorable safety outcomes through 12 months, offering timely insights into contemporary LAAC practice and post‑implant antithrombotic management.

In this episode, Francis Marchlinski, MD, Deputy Editor of JACC: Clinical Electrophysiology, discusses a novel study evaluating high‑voltage pulsed field ablation (hv‑PFA) for redo ventricular tachycardia ablation in patients with nonischemic cardiomyopathy. He highlights why VT ablation remains particularly challenging in this population, the rationale for using high‑voltage PFA to achieve deeper and more durable lesion formation, and the key findings from this early clinical experience. Dr. Marchlinski also comments on the encouraging efficacy signals, important safety considerations—including device and mapping system interactions—and what these results may mean for the future evolution of VT ablation strategies.

In this episode, Dr. Kenneth Ellenbogen discusses an important analysis from the PRAETORIAN-DFT trial examining whether shock impedance can reliably predict defibrillation success after subcutaneous ICD implantation. While low impedance values are increasingly used in practice as a surrogate for defibrillation testing, this multicenter study shows that although an impedance

In this episode, Jeremy Moore, MD, MS, Associate Editor of JACC: Clinical Electrophysiology, reviews a study showing that adults with Ebstein anomaly face a high lifetime risk of atrial arrhythmias, with more than half developing one by age 60. The most common arrhythmias were intra-atrial re-entrant and focal atrial tachycardias, which were more frequent than atrial fibrillation. Older age, prior cardiac surgery, significant tricuspid valve leakage, and severe right ventricular dysfunction were key risk factors, underscoring the need for lifelong specialized follow-up.

In this JACC Advances Author One-on-One podcast, Editor-in-Chief Dr. Dinesh Kalra and Associate Editor Dr. Purvi Parwani speak with Dr. Priscilla Wesley and Dr. Renuka Jain about their prospective study on occupational radiation exposure among interventional echocardiographers during structural heart procedures. The authors discuss findings from 230 TEE-guided interventions, including left atrial appendage occlusion, transcatheter mitral interventions, and transcatheter tricuspid procedures. The conversation highlights reassuring data on pelvic radiation exposure while addressing ongoing concerns about chest-level exposure, shielding strategies, and opportunities to improve safety in the structural heart cath lab. Tune in for an engaging discussion on radiation safety and the future of structural heart imaging.

The JACC Advances Podcast brings you expert perspectives on the most important developments in cardiovascular medicine. Through author one-on-one interviews, deep-dive discussions with editorial experts, and concise monthly research summaries, each episode highlights impactful science, clinical innovation, and emerging evidence from JACC Advances. Join us every month to stay informed on the latest breakthroughs shaping cardiovascular care.

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Integrated Hemodynamic Measures of Cardiac Function and Association With Clinical Outcomes.