JAMA Senior Editor Derek Angus, MD, MPH, and JAMA Associate Editor Christopher Seymour, MD, MSc, discuss 4 critical care trials published in JAMA and simultaneously presented at the 2024 CCR Down Under meeting in Melbourne, Australia, with JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS. Related Content:

• Electronic Sepsis Screening Among Patients Admitted to Hospital Wards
• Early Restrictive vs Liberal Oxygen for Trauma Patients
• High-Flow Nasal Oxygen vs Noninvasive Ventilation in Patients With Acute Respiratory Failure
• Do Sepsis Alerts Help?
• Reevaluating Respiratory Support in Acute Respiratory Failure—Insights From the RENOVATE Trial and Implications for Practice
• Is High-Flow Oxygen the Standard for All Patients With Acute Respiratory Failure?
• Biomarker-Guided Antibiotic Duration for Hospitalized Patients With Suspected Sepsis