Peter Hotez, MD, PhD, founding dean of the National School of Tropical Medicine, codirector of the Texas Children's Center for Vaccine Development, and professor of pediatrics and molecular virology and microbiology at Baylor College of Medicine and Michael E. Mann, presidential distinguished professor and director of the Center for Science, Sustainability and the Media at the University of Pennsylvania and author of several books and co-author and, together, co-authors of Science Under Siege: How to Fight the Five Most Powerful Forces that Threaten Our World (PublicAffairs, 2025), talk about the specific groups promoting anti-science and how they make fighting the global threats of disease and climate change harder.