1) Restless legs syndrome and 2) evidence-based medicine (part 2). This podcast for the Neurology Journal begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the print issue of Neurology. In the second segment Dr. Aman Savani interviews Dr. Diego Garcia-Borreguero about his paper on restless legs syndrome. In the next segment, Dr. Ryan Overman is reading our e-Pearl of the week about fatal gastroenteritis. In the next part of the podcast Dr. Michael Benatar interviews Dr. Mark Conaway for part two on evidence-based medicine relative risk, relative risk reduction, absolute risk reduction, and NNT for our Lesson of the Week. You may also want to check out the other two-part series on evidence-based medicine where Dr. Michael Benatar interviewed Dr. Gary Gronseth for our March 30 and April 6 Lesson of the Week. The participants had nothing to disclose except Dr. Garcia-Borreguero. Dr. Garcia-Borreguero has served on scientific advisory boards for and received speaker honoraria from Boehringer Ingelheim, GlaxoSmithKline, UCB, Pfizer Inc, XenoPort, Inc., sanofi-aventis, Jazz Pharmaceuticals, and Merck & Co., Inc.