Matters Microbial #88: Microbial Interactions in Cystic Fibrosis April 24, 2025

Today, Dr. Reed Stubbendieck, Assistant Professor of Microbiology & Molecular Genetics at Oklahoma State University joins the #QualityQuorum to discuss how microbes and the host communicate with one another in the cystic fibrosis lung.

Host: Mark O. Martin

Guest: Reed Stubbendieck

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Links for this episode

• An overview of cystic fibrosis as a disease with a genetic link.
• A review of the microbiome of the cystic fibrosis lung.
• An overview of biofilms.
• An interesting role for extracellular DNA itself as a "building block" of biofilms.
• An overview of polymicrobial communities.
• Life in mucus—an interesting essay.
• An overview of Pseudomonas aeruginosa.
• Pseudomonas and the siderophore pigment pyoverdin which is not only about iron, but also bacterial conflict and cooperation.
• An interesting overview of microbe-microbe interactions, often called "sociomicrobiology," and an introductory article on this topic.
• A review of the nasal microbiome.
• The organism Rothia, understudied and of interest to Dr. Stubbendieck's research group.
• Some work from Dr. Stubbendieck's group describing how Rothia is helpful in inhibiting some disease causing bacteria.
• The organism Dolosigranulum pigrum, also understudied and of interest to Dr. Stubbendieck's research group.
• More work from Dr. Stubbendieck's group with another possibly probiotic bacterium, Dolosigranulum pigrum, that may protect against disease causing microbes.
• Dr. Stubbendieck's faculty website.
• Dr. Stubbendieck's very interesting research group website.

Intro music is by Reber Clark

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