To claim credit for this episode, visit: https://ce.mayo.edu/online-education/content/mayo-clinic-talks-podcast-genes-your-health#group-tabs-node-course-default1

Guest: Jessica A. Wright, Pharm.D., R.Ph.

Host: Denise M. Dupras, M.D., Ph.D.

Pharmacogenomics helps to identify how your patients’ DNA may affect their response to medications. But there's a lot of different genes! How do we get started? What resources are out there? Do we have to worry about every drug a patient is on? Find out these answers and more in episode three of the Genes & Your Health Edition from the Mayo Clinic Center for Individualized Medicine.

Additional resources:

• PharmGKB: pharmgkb.org

Connect with the Mayo Clinic School of Continuous Professional Development online at https://ce.mayo.edu/ or on Twitter @MayoMedEd.

Guest: David G. Lott, M.D.

Host: Amit K. Ghosh, M.D. (@AmitGhosh006)

About 60,000 Americans have had their vocal cords removed due to disease or trauma necessitating a laryngectomy. Post-laryngectomy, patients are unable to speak, are at risk for aspiration, and many suffer from significant anguish resulting in depression. Fortunately, there are several treatment options available, the first being laryngeal transplant. While laryngeal transplantation allows patients to smell, taste, swallow, and communicate, it has drawbacks. Currently only a small number of larynx transplants are done in the U.S., and only a select few patients with laryngectomy qualify for larynx transplant. In this episode, Dr. David Lott, division chair of laryngology at Mayo Clinic’s Arizona campus, discusses the role of regenerative medicine, which has shown promise in using 3D printing and a patient’s stem cells in creating a larynx.

Connect with the Mayo Clinic School of Continuous Professional Development online at https://ce.mayo.edu/ or on Twitter @MayoMedEd.

To claim credit for this series, visit: https://ce.mayo.edu/online-education/content/mayo-clinic-talks-podcast-genes-your-health#group-tabs-node-course-default1

Guests: Andrew D. Badley, M.D. (@BadleyAndrew); Matthew J. Binnicker, Ph.D. (@DrMattBinnicker)

Host: Denise M. Dupras, M.D., Ph.D.

COVID-19. Variants. The future. Does one test fit all?  Will the vaccine continue to provide protection against future variants? What makes the Delta variant more transmissible? Join the second episode of our Genes & Your Health Edition from the Mayo Clinic Center for Individualized Medicine to learn how viral genetics influence transmission, diagnosis, and severity of COVID-19.

Additional resources:

• Mayo Clinic Center for Individualized Medicine: https://www.mayo.edu/research/centers-programs/center-individualized-medicine

Connect with the Mayo Clinic School of Continuous Professional Development online at https://ce.mayo.edu/ or on Twitter @MayoMedEd.

To claim credit for this episode, visit: https://ce.mayo.edu/online-education/content/mayo-clinic-talks-podcast-genes-your-health#group-tabs-node-course-default1

Guests: Matthew J. Ferber, Ph.D. (@Matt_Ferber); Teresa M. Kruisselbrink, M.S., CGC (@T_Kruisselbrink); William C. Palmer, M.D. (@williampalmermd)

Host: Denise M. Dupras, M.D., Ph.D.

For so long we've heard Genetic Testing is coming. Well guess what, it’s here!  We have over 25 million people who have chosen to participate in direct-to-consumer testing alone. What does this mean for primary care, and does it matter? Find out in the first episode of our Genes & Your Health Edition from the Mayo Clinic Center for Individualized Medicine.

Additional resources:

• TAPESTRY Study: https://www.mayo.edu/research/clinical-trials/cls-20477323?_ga=2.268706548.460922620.1627479724-1519128218.1623079535

Connect with the Mayo Clinic School of Continuous Professional Development online at https://ce.mayo.edu/ or on Twitter @MayoMedEd.

Guest: Elitza S. Theel, Ph.D. (@ElliTheelPhD)

Host: Amit K. Ghosh, M.D. (@AmitGhosh006)

Dr. Elitza Theel, Professor of Laboratory Medicine and Pathology and Director of Infectious Diseases Serology Laboratory at Mayo Clinic’s Rochester Campus, discusses our immune response to vaccination and natural infection and outlines the different types of antibody assays currently available. Dr. Theel also discusses the concept of herd immunity in the context of different circulating SARS-CoV-2 variants and the increased need to get higher rates of vaccination in the community as the infectivity and transmissibility of circulating SARS-CoV-2 variants changes. We also discuss the status of correlates of protective immunity against SARS-CoV-2 and the need for booster vaccine doses for immunocompromised individuals. 

Additional resources:

• Interim Guidelines for COVID-19 Antibody Testing in Clinical and Public Health Settings https://www.cdc.gov/coronavirus/2019-ncov/lab/resources/antibody-tests-guidelines.html

Connect with the Mayo Clinic’s School of Continuous Professional Development online at https://ce.mayo.edu/ or on Twitter @MayoMedEd.

Guest: Aaron M. Potretzke, M.D. (@potretzke)

Host: Darryl S. Chutka, M.D. (@ChutkaMD)

Microscopic hematuria, and less commonly gross hematuria, are conditions commonly seen by the primary care provider. Malignancy is the most ominous cause of hematuria. Fortunately, other causes are much more likely. Since this is a relatively common health condition, when should we investigate hematuria and what should the evaluation consist of? How do we evaluate a patient’s risk for urinary tract malignancy? Dr. Aaron Potretzke, a urologist at Mayo Clinic joins us to discuss these questions.

Specific topics:

• Definition of hematuria

Additional resources:

• American Urological Association hematuria guideline and algorithm: https://www.auanet.org/guidelines/guidelines/microhematuria

Connect with the Mayo Clinic’s School of Continuous Professional Development online at https://ce.mayo.edu/ or on Twitter @MayoMedEd.

Guest: Edward R. Laskowski, M.D. (@DrEdSportsMed)

Host: Sanjeev (Sanj) Kakar, M.D. (@sanjkakar)

Daily exercise has so many health and emotional benefits – it can help decrease your blood pressure, promote cardiovascular wellbeing, alleviate stress, and assist with weight loss and blood sugar control. Parkinson’s disease is a condition that affects the central nervous system, and in particular the brain, that can lead to shakiness, poor balance, and frequent falls. Joining us in this episode is Edward Laskowski, M.D., a professor of physical medicine and rehabilitation and sports medicine specialist at Mayo Clinic’s Rochester Campus, to discuss why exercise is first-line treatment for your Parkinson’s patients.

Additional resources:

• Mayo Clinic: https://www.mayoclinic.org/diseases-conditions/parkinsons-disease/symptoms-causes/syc-20376055

Connect with the Mayo Clinic’s School of Continuous Professional Development online at https://ce.mayo.edu/ or on Twitter @MayoMedEd.

Guest: Jeremy K. Cutsforth-Gregory, M.D. (@JCGneuro)

Host: Darryl S. Chutka, M.D. (@ChutkaMD)

Parkinson’s Disease is one of the more common neurodegenerative diseases, in fact, patients with Parkinson’s outnumber those with multiple sclerosis, ALS, and muscular dystrophy combined. It tends to affect older patients, although on rare occasions it can be seen in those under the age of 50. It can have a devastating effect on an individual’s lifestyle as the physical symptoms of the disease tend to gradually progress over years. This podcast will feature Dr. Jeremy Cutsforth-Gregory, a neurologist at the Mayo Clinic, as we discuss the evaluation and management of Parkinson’s Disease.

Specific topics:

• Pathophysiology of Parkinson’s Disease

Connect with the Mayo Clinic’s School of Continuous Professional Development online at https://ce.mayo.edu/ or on Twitter @MayoMedEd.

Guest: Carol L. Kuhle, D.O., M.P.H. (@clkejd)

Host: Anjali Bhagra, M.D. (@anjalibhagramd)

Anjali Bhagra, M.D., and Carol L. Kuhle, D.O., M.P.H., discuss the narrative they recently published in Mayo Clinic Proceedings, which outlines and highlights the further widening of preexisting gender disparities in response to the COVID-19 pandemic. What can we do to identify and mitigate these issues?

Additional resources:

• Nordhues, HC. Bhagra, A. Stroud, NN. Vencill, JA. Kuhle, CL. COVID-19 gender disparities and mitigation recommendations: a narrative review. Mayo Clin Proc. 2021 April 20; 96(7): 1907-1920. doi: https://doi.org/10.1016/j.mayocp.2021.04.009

Connect with the Mayo Clinic’s School of Continuous Professional Development online at https://ce.mayo.edu/ or on Twitter @MayoMedEd.

This episode is shared from Mayo Clinic Q&A and was recorded August, 2021

Guest: Gregory A. Poland, M.D. (@drgregpoland)

Host: Halena M. Gazelka, M.D. (@hmgazelkamd)  

A fourth COVID-19 surge is blanketing the U.S., and the delta variant is the culprit.

"Where did this delta variant come from? It came from unvaccinated people getting infected in large numbers allowing the virus to continue mutating," says Dr. Gregory Poland, an infectious diseases expert and head of Mayo Clinic's Vaccine Research Group.

In the past, a person with COVID-19 might infect two to four people. But with the delta variant, one person can infect nine people, according to Dr. Poland. He says if you want to protect yourself and your family, wear a mask, especially indoors, and get vaccinated with an appropriate series of one of the COVID-19 vaccines.

"These are the most studied vaccines in the history of the world," Dr. Poland emphasizes. "There have never been this many people who have received this many doses of vaccines during this amount of time with as much scrutiny as these COVID-19 vaccines have had."

In this Mayo Clinic Q&A podcast, Dr. Poland answers questions about a person's waning immunity and the likelihood of COVID-19 booster shots. He also explains the two phases of immunity and goes into detail about the extensive Federal Drug Administration license approval process for COVID-19 vaccines.

AskMayoExpert COVID-19 Resources: https://askmayoexpert.mayoclinic.org/navigator/COVID-19

Connect with the Mayo Clinic’s School of Continuous Professional Development online at https://ce.mayo.edu/ or on Twitter @MayoMedEd.