Dwarkesh Podcast

Michael Nielsen – How science actually progresses


Listen Later

Really enjoyed chatting with Michael Nielsen about how we recognize scientific progress.

It's especially relevant for closing the RL verification loop for scientific discovery.

But it's also a surprisingly mysterious and elusive question when you look at the history of human science.

We approach this question stories like Einstein (who claimed that he hadn't even heard of the famous Michelson-Morley experiment, which is supposed to have motivated special relativity, until after he had come up with the theory), Darwin (why did it take till 1859 to lay out an idea whose essence every farmer since antiquity must have observed?), Prout (how do you recognize that isotopes exist if you cannot chemically separate them?), and many others.

The verification loop on scientific ideas is often extremely long and weirdly hostile. Ancient Athenians dismissed Aristarchus's heliocentrism in the 3rd century BC because it would imply that the stars should shift in the sky as the Earth orbits the sun. The first successful measurement of stellar parallax was in 1838. That's a 2,000-year verification loop.

But clearly human science is able to make progress faster than raw experimental falsification/verification would imply, and in cases where experiments are very ambiguous. How?

Michael has some very deep and provocative hypotheses about the nature of progress. One I found especially thought-provoking is that aliens will likely have a VERY different science + tech stack than us. Which contradicts the common sense picture of a linear tech tree that I was assuming. And has some interesting implications about how future civilizations might trade and cooperate with each other.

Watch on Youtube; read the transcript.

Sponsors

* Labelbox researchers built a new safety benchmark. Why? Well, current safety benchmarks claim that attacks on top models are successful only a few percent of the time, but the prompts in those benchmarks don’t reflect how real bad actors actually write. You can read Labelbox’s research here. If this could be useful for your work, reach out at labelbox.com/dwarkesh

* Mercury has an MCP that lets you give an LLM access to your full transaction history, including things like attached receipts and internal notes. I just used it to categorize my 2025 transactions, and it worked shockingly well. Modern functionality like this is exactly why I use Mercury. Learn more at mercury.com

* Jane Street’s ML engineers presented some of their GPU optimization workflows at GTC, showing how they use CUDA graphs, streams, and custom kernels to shave real time off their training runs. You can watch the full talk here. And they open-sourced all the relevant code here. If this kind of stuff excites you, Jane Street is hiring — learn more at janestreet.com/dwarkesh

Timestamps

(00:00:00) – How scientific progress outpaces its verification loops

(00:17:51) – Newton was the last of the magicians

(00:23:26) – Why wasn’t natural selection obvious much earlier?

(00:29:52) – Could gradient descent have discovered general relativity?

(00:50:54) – Why aliens will have a different tech stack than us

(01:15:26) – Are there infinitely many deep scientific principles left to discover?

(01:26:25) – What drew Michael to quantum computing so early?

(01:35:29) – Does science need a new way to assign credit?

(01:43:57) – Prolificness versus depth

(01:49:17) – What it takes to actually internalize what you learn



Get full access to Dwarkesh Podcast at www.dwarkesh.com/subscribe
...more
View all episodesView all episodes
Download on the App Store

Dwarkesh PodcastBy Dwarkesh Patel

  • 4.6
  • 4.6
  • 4.6
  • 4.6
  • 4.6

4.6

475 ratings


More shows like Dwarkesh Podcast

View all
The Twenty Minute VC (20VC): Venture Capital | Startup Funding | The Pitch by Harry Stebbings

The Twenty Minute VC (20VC): Venture Capital | Startup Funding | The Pitch

536 Listeners

Conversations with Tyler by Mercatus Center at George Mason University

Conversations with Tyler

2,461 Listeners

The a16z Show by Andreessen Horowitz

The a16z Show

1,105 Listeners

Y Combinator Startup Podcast by Y Combinator

Y Combinator Startup Podcast

233 Listeners

All-In with Chamath, Jason, Sacks & Friedberg by All-In Podcast, LLC

All-In with Chamath, Jason, Sacks & Friedberg

10,254 Listeners

Big Technology Podcast by Alex Kantrowitz

Big Technology Podcast

512 Listeners

Moonshots with Peter Diamandis by PHD Ventures

Moonshots with Peter Diamandis

602 Listeners

No Priors: Artificial Intelligence | Technology | Startups by Conviction

No Priors: Artificial Intelligence | Technology | Startups

150 Listeners

Latent Space: The AI Engineer Podcast by Latent.Space

Latent Space: The AI Engineer Podcast

101 Listeners

The AI Daily Brief: Artificial Intelligence News and Analysis by Nathaniel Whittemore

The AI Daily Brief: Artificial Intelligence News and Analysis

688 Listeners

"Econ 102" with Noah Smith and Erik Torenberg by Turpentine

"Econ 102" with Noah Smith and Erik Torenberg

147 Listeners

BG2Pod with Brad Gerstner and Bill Gurley by BG2Pod

BG2Pod with Brad Gerstner and Bill Gurley

475 Listeners

AI + a16z by a16z

AI + a16z

34 Listeners

TBPN by John Coogan & Jordi Hays

TBPN

140 Listeners

Uncapped with Jack Altman by Alt Capital

Uncapped with Jack Altman

42 Listeners