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Summary:  In this episode we discuss monoclonal antibodies (the generic drug name ends in -mab), how do they work, and why can antibodies be used for so many different indications?  These indications include being used as an antiviral (against Covid till the virus mutated), a cancer treatment, against many autoimmune diseases, asthma, osteoarthritis, organ rejection and many other conditions.  Drugs made from living organisms are called biologics - these monoclonal antibodies fall into this category and are specifically targeted therapies that represent a powerful, new and evolving tool in medicine.          

Topics Covered:

·      Monoclonal Antibody (-mab) – big molecule 01:23

·      Antigen 02:30

·      Mab Production (Biologic) 03:15

·      Mab Uses 04:10

·      Targeted Therapy 04:40

·      Desired Effect & Collateral Damage 05:30

·      Prednisone 06:05

·      Rheumatoid Arthritis & Inflammatory Bowel Disease 07:19

·      Specificity 07:55

·      Infection Risk 08:24

·      MD Discussion/Shared Decision Making 09:40

·      Positive, Informed and Following Up 10:30

·      Insulin and Monoclonal Antibody – Injection 11:00

·      Small Molecule Targeted Immunotherapy (-ib) 13:57

·      Rinvoq (upadacitinib) 15:15

·      JAK Inhibitors 16:23

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