Featuring articles on andexanet and factor Xa inhibitor–associated hemorrhage, perioperative nivolumab in resectable lung cancer, olezarsen for familial chylomicronemia syndrome, and olezarsen for hypertriglyceridemia; a review article on climate change, extreme heat, and health; a case report of a woman with worsening rash; and Perspective articles on focusing on health care equity, on underestimated challenges for social care initiatives, on integrating public health and health care, and on learning to say goodbye.