Featuring articles on doxorubicin plus trabectedin in leiomyosarcoma, a monoclonal antibody for migraine prevention, adjunctive argatroban or eptifibatide for ischemic stroke, and a new orthonairovirus associated with febrile illness; a review article on pancreatic cysts; a case report of a man with pain and dyspnea; a Medicine and Society on building a community of medical learning; and Perspectives on supreme power, on shared savings for nursing homes, on moral injury and the global health workforce crisis, and on asking patients if they feel safe at home.