What happens when AI starts doing science? We talk with Stanford computer scientist Jure Leskovec about AI agents that find patterns in large datasets, come up with hypotheses and try to kill them with more data, enduring the tedious work human scientists would rather avoid. What are we human scientists still uniquely good for? Taste, judgment, intuition, emotion, procrastination? And we discuss whether AI might be opening up a whole new continent of discoveries, a terra incognita with plenty of ways to get lost and found.

Worth a look: 50×50: Science Across America – 50 creators, 50 scientists, 50 states, 50 videos over ten weeks in 2026, from the Independent Media Initiative. It goes where science actually happens, with the people who actually do it – which is the part we're always most curious about. https://www.5050science.com/

The Night Science Podcast is produced by the Night Science Institute. For more information on Night Science, visit night-science.org .

What can early-career scientists teach us about creativity? For this special episode, we talked to PhD students and postdocs about their creative processes. They told us about finding scientific ideas in art museums, sketching on whiteboards, borrowing concepts from other disciplines, going to unrelated seminars, swimming, hiking, talking in pubs, and deliberately letting ideas lie fallow like in a crop rotation system. Through this diversity, a few themes kept coming back: openness, play, visual thinking, talking, and incubation. This episode is also a reminder of something that is easy to forget amid the frustrations of academic life: science gives us the extraordinary freedom to think without bounds, ask questions, and spend our lives solving puzzles.

The Night Science Podcast is produced by the Night Science Institute. For more information on Night Science, visit night-science.org .

What can comedy teach us about scientific discovery? With stand-up comedian and former research scientist Sarah Adelman, we discuss the surprising parallels between jokes and discoveries. Sarah shares her path from public health research to comedy, and we explore how the willingness to bomb on stage, searching for punchlines, and creating a playful “writer’s room” atmosphere have close analogies in the creative scientific process. 

The Night Science Podcast is produced by the Night Science Institute. For more information on Night Science, visit night-science.org .

Professor Robert Root-Bernstein has not only made many scientific discoveries,  but has also written extensively about the creative process, including in Sparks of Genius (with Michele Root-Bernstein) and in his latest book, The Arts of Eminent Scientists. Bob found that successful scientists do not treat their “lazy” creative pursuits, such as painting, music, or writing, as distractions from science, but integrate them into one coherent life. Among other things, we also explore problem finding and how artistic practices can sharpen observation and generate powerful analogies.

The Night Science Podcast is produced by the Night Science Institute. For more information on Night Science, visit night-science.org .

Professor Lois Hetland, the former chair of art education at the Massachusetts College of Art, joins us to ask: what do artists and scientists truly share? We explore the striking parallels between artistic practice and scientific discovery – between Night Science, the messy and playful mental state where ideas are formed, and her “Studio Habits of Mind”, such as observing closely, envisioning possibilities, and exploring at the edge of the unknown. We converge on a central point: how frustration and insecurity are inherent in the creative process wherever it unfolds. And Lois argues that we can cultivate creativity through the right environment, one that embraces experimentation, mistakes, and sustained engagement – the same topics that many of our scientist guests have brought up.

The Night Science Podcast is produced by the Night Science Institute. For more information on Night Science, visit night-science.org .

Melanie Mitchell is a professor at the Santa Fe Institute and a leading thinker on artificial intelligence, analogy, and abstraction. She reflects on how analogy quietly drives creativity and scientific discovery even in the most rigorous fields. Analogies often emerge during moments of mental rest and don’t need to be accurate to nudge you into new avenues of thinking. We discuss how many core scientific concepts began as metaphors, how analogies can both illuminate and mislead, and whether large language models truly grasp abstraction. The conversation ranges from the role of analogies in Einstein’s thought process to evolutionary “landscapes” and the balance between generative night science and critical day science.

The Night Science Podcast is produced by the Night Science Institute. For more information on Night Science, visit night-science.org .

Amy Shyer & Alan Rodrigues co-direct the Laboratory of Morphogenesis at Rockefeller University. They are also married. Together, we reflect on what it means to think creatively in biology. Amy and Alan discuss the importance of challenging established frameworks, cultivating a “feeling for the organism,” and balancing conceptual imagination with close attention to observable phenomena. They are true science buddies, with their complementarity and partnership allowing them to challenge each other by diving deeper into the ambiguity and loneliness of research.

Join our Train-the-Trainer Event to learn how to teach Night Science, April 24th at the New York Academy of Sciences! https://night-science.org/train-the-trainer-workshop/

The Night Science Podcast is produced by the Night Science Institute. For more information on Night Science, visit night-science.org .

It’s surprising that for centuries, scientists have left the study of how to do science largely to non-scientists. Not anymore – thanks to the young field of cognitive epistemology. In this episode, we discuss the exciting – and surprising – science of doing science with Marina Dubova, a postdoc at the Santa Fe Institute and soon a professor at UC Berkeley. Marina found, for example, that to get the most powerful theories, you should not plan the collection of data with a view to falsify or validate existing hypotheses; instead, try to get as diverse a dataset as possible. It adds a new angle to an idea that we discussed in many previous episodes: that discoveries often arise from exploratory data collection. Based on Marina’s research and her own process, we also discuss how science thrives on diversity at all levels – data, ideas, questions, scientists – and on the use of analogies and metaphors. 

The Night Science Podcast is produced by the Night Science Institute. For more information on Night Science, visit night-science.org .

Ken Stanley is a highly regarded researcher in machine learning and artificial intelligence. After leaving his professorship at the University of Central Florida, he cofounded Geometric Intelligence (now Uber AI Labs), and he is now Senior Vice President of Open-Endedness at LilaSciences. In this episode, Ken explains why ambitious objectives often backfire: the real stepping stones to breakthrough discoveries rarely look like progress toward the goal, so a direct pursuit can blind us to the opportunities that matter most. Together, we connect these ideas to night science, scientific intuition, and the pressure to justify research with hypotheses and deliverables, and we argue for a healthier system that funds exploration, curiosity, and the creation of new “playgrounds” for discovery.

The Night Science Podcast is produced by the Night Science Institute. For more information on Night Science, visit night-science.org .

Maria Leptin is the President of the ERC, the European Research Council, and Professor of genetics at the University of Cologne. In this episode, Maria describes her own path as one driven by observation and curiosity rather than long-term planning, and discusses why small, intellectually vibrant institutes often outperform large labs. We discuss how funding agencies can better support bold ideas, and we explore how to evaluate creativity in grant proposals and why a focus on feasibility can stifle innovation. We also consider the role of grant writing in shaping ideas, the differences between academia and industry, and the importance of stable yet non-complacent careers.

The Night Science Podcast is produced by the Night Science Institute. For more information on Night Science, visit night-science.org .®