Recent research by Antonio Carroccio, MD that suggests the existence of non-celiac wheat sensitivity as a distinct clinical condition is the topic of discussion between AJG co-editor William D. Chey, MD, FACG and Joseph A. Murray, MD, who is lead author of an upcoming clinical management guideline for celiac disease to be published in the Red Journal. Dr. Murray helps define non-celiac gluten sensitivity, explores why gluten-free diets are unsatisfactory as a diagnostic tool, and explains the need for scientific advancement in this area. Dr. Carroccio’s paper was published in the December issue of The American Journal of Gastroenterology.