1) Spectrum of cognition short of dementia and 2) Topic of the month: Neuromyelitis optica. This podcast for the Neurology Journal begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the print issue of Neurology. In the second segment Dr. Jeff Burns interviews Dr. David Knopman about his paper on the spectrum of cognition short of dementia. Dr. Ted Burns is interviewing Dr. Terrence Cascino for our "What's Trending" feature of the week about what AAN is doing to combat the trend of physician burnout. In the next part of the podcast Dr. Stacey Clardy interviews Dr. Sean Pittock about the topic of neuromyelitis optica assay development, treatments and mimics, including MOG antibodies. The participants had nothing to disclose except Drs. Jeff Burns, Knopman, Burns, Cascino, Clardy and Pittock.Dr. Jeff Burns serves on the editorial board for Journal of Alzheimer's Disease; receives royalties for the publications of Early diagnosis and treatment of mild cognitive impairment and Dementia: An atlas of investigation and diagnosis; is a consultant for PRA International and receives research support from the NIH, Alzheimer's Drug Discovery Foundation, Elan, Janssen Pharmaceuticals Inc., Wyeth, Pfizer Inc, Novartis Pharmaceuticals Ltd, Danone, Avid Radiopharmaceuticals, Merck Serono and for clinical trials. Dr. Knopman served as Deputy Editor for Neurology®; serves on a Data Safety Monitoring Board for Lundbeck Pharmaceuticals and for the DIAN study; is an investigator in clinical trials sponsored by TauRX Pharmaceuticals, Lilly Pharmaceuticals and the Alzheimer's Disease Cooperative Study; serves as a consultant to the Bluefield Project to Cure Frontotemporal Dementia; and receives research support from the NIH.Dr. Ted Burns serves as Podcast Editor for Neurology®; and has received research support for consulting activities with UCB, CSL Behring, Walgreens and Alexion Pharmaceuticals, Inc.Dr. Cascino serves as President for the American Academy of Neurology.Dr. Clardy receives research support from the Western Institute for Biomedical Research.Dr. Pittock receives research support from Alexion, Guthy Jackson Charitable Foundation and the NIH.