1) Paroxysmal dyskinesia and hemiplegic migraine and 2) Topic of the month: Encephalopathy caused by systemic disease. This podcast for the Neurology Journal begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the print issue of Neurology. In the second segment Dr. Jeff Waugh interviews Drs. Renzo Guerrini and Alice Gardiner about their papers on paroxysmal dyskinesia and hemiplegic migraine. Dr. Stacey Clardy is reading our e-Pearl of the week about plus-minus lid syndrome. In the next part of the podcast Dr. Ted Burns interviews Drs. Steven Lewis and Allison Weathers about encephalopathy caused by liver and kidney dysfunction. The participants had nothing to disclose except Drs. Waugh, Guerrini, Gardiner, Clardy, Burns, Lewis and Weathers.Dr. Waugh serves on the editorial board of the Journal of Pediatric Biochemistry.Dr. Guerrini serves as an Associate Editor for Epilepsia, serves on the editorial boards for Seizure, BMC Medical Genetics, Topics in Epilepsy, Journal of Pediatric Epilepsy, Epileptic Disorders and European Neurological Journal, serves on the International Advisory Board for Progress in Epileptic Disorders; has received honoraria from Biocodex, UCB, Eisai Inc, ValueBox, Viropharma and EMA (European Medicine Agency), received funding for travel from Japanese Epilepsy Society and Weill Cornell Medical College; receives research support from the Italian Ministry of Health, the European Community Sixth Framework Thematic Priority Life Sciences, Genomics and Biotechnology for Health, the Italian Ministry of Education, University and Research, the Tuscany Region, the Telethon Foundation, and the Mariani Foundation; receives royalties for the books: Epilepsy and Movement disorders, Aicardi's Epilepsy in children, Progress in epileptic spasms and West syndrome, Epilepsy and migraine, The causes of epilepsy and Dravet syndrome.Dr. Gardiner receives research support from The Muscular Dystrophy Campaign.Dr. Clardy serves on the editorial team for the Neurology® Resident and Fellow Section. Dr. Burns serves as Podcast Editor for Neurology®; performs EMG studies in his neuromuscular practice (35% effort); and has received research support for consulting activities with CSL Behring and Alexion Pharmaceuticals.Dr. Lewis serves as CME Section Co-Editor for Neurology® and as Associate Editor for Continuum: Lifelong Learning in Neurology®; receives royalties for the books: Field Guide to the Neurologic Examination and Neurology for the Non-Neurologist and anticipates receiving royalties for the book: Neurologic Disorders due to Systemic Disease.