OncoPharm

We all should do what we can to "flatten the curve" and that includes our patients on treatment. While there is no such thing as elective chemo, there are some practical ways we can minimize patients needing to come into our facilities.

Looking back at a 2012 NYT op-ed (https://www.nytimes.com/2012/10/15/opinion/a-hospital-says-no-to-an-11000-a-month-cancer-drug.html) that led to a 50% price decrease in a biologic cancer medication.

A plethora of #oncopharm updates!

Isatuximab is approved and neratinib gets another breast cancer indication (2:00)

Pembrolizumab with chemo for triple-negative breast cancer (8:50)

New EPOC updated survival analysis on FOLFOX+cetuximab in isolated liver metastatic colon cancer (15:00)

Precision medicine in pancreatic cancer (19:30)

Cladribine + rituximab for hairy cell leukemia (23:30)

Two recent publications add to our knowledge concerning the utility of CYP2D6 genotyping and tamoxifen.

TARGET-1: https://www.ncbi.nlm.nih.gov/pubmed/31821071

Tamoxifen D/C rates by 2D6 genotype: https://www.ncbi.nlm.nih.gov/pubmed/31800347

You've heard of CAR-T therapy, and now it's time to learn about CAR-NK cells.

Reference: https://www.nejm.org/doi/full/10.1056/NEJMoa1910607

Drug-drug interactions are a key consideration when determining which NK-1 antagonist to use in patients receiving highly emetogenic chemotherapy. We discuss the issues for (fos)aprepitant, netupitant, & rolapitant.

A nice aprepitant review (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595939/) and the case for an aprepitant-vincristine interaction (https://doi.org/10.1177/1078155219870840).

All the need-to-know items about the latest #oncopharm approved drug, tazemetostat, to start the Pod. We end (9:15) with a brief discussion of how gut bacteria may lead to gemcitabine resistance.

Foundations of OncoPharm: Bendamustine

New Drug Update! We discuss the efficacy and safety data surrounding avapritinib's approval as well as its likely role in GIST management.

How common are upon safety concerns from FDA on newly approved #oncopharm agents? Does the accelerated approval process lead to more safety updates? We discuss (https://doi.org/10.1634/theoncologist.2019-0653).

We also look at a possible way to mitigate 6-MP hepatoxicity (5:45) using allopurinol (https://doi.org/10.1080/10428194.2019.1702183).

Finally (10:55) we review the most recent FDA indications for olaparib and pembrolizumab.