PeerView Family Medicine & General Practice CME/CNE/CPE Audio Podcast

Go online to PeerView.com/ZHN860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. In this activity, an expert in rheumatic diseases discusses strategies to select and optimize treatment for individual patients with RA and PsA, focusing on the appropriate clinical utilization of newer treatment options (ie, JAK inhibitors). Upon completion of this activity, participants will be able to: Outline advances that have improved the quality of care in rheumatic diseases, Explain the role of the JAK/STAT signaling pathway in the pathophysiology of RA and PsA, Summarize efficacy and safety data related to current JAK inhibitors for the treatment of RA and PsA, Treat RA and PsA in accordance with current evidence and guidelines, recognizing the role of non-anti-TNF therapies in patients with active disease, Incorporate JAK inhibitors into treatment plans for individual patients with RA or PsA, recognizing the importance of achieving therapeutic targets and a patient-centered approach to care.

Go online to PeerView.com/KYQ860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. Cardiovascular disease (CVD), type 2 diabetes mellitus (T2DM), and chronic kidney disease (CKD) have intersecting risk factors, and their prevalence has increased dramatically over the past several decades. Accumulating evidence has shown that SGLT2 inhibitors not only improve glycemic control but also potentially target other chronic diseases at the cardiorenal intersection, resulting in improved cardiovascular and renal endpoints for patients with or without T2DM. Revised treatment guidelines from leading endocrinology and cardiology societies prioritize SGLT2 inhibitors, especially in patients with T2DM and atherosclerotic CVD, heart failure, and/or CKD. In this activity, based on a recent live webcast, a multidisciplinary panel of experts reviews FDA-approved indications, treatment guidelines, and the accumulating evidence for SGLT2 inhibitors in comorbid cardiometabolic diseases. To integrate clinical evidence into practice, the experts also present complex patient cases to offer strategies for personalizing treatment plans and improving outcomes for patients with T2DM, heart failure, and CKD. Upon completion of this activity, participants should be able to: Recognize FDA-approved indications and the placement of SGLT2 inhibitors in current treatment guidelines, Summarize the proposed mechanism(s) supporting the therapeutic potential of SGLT2 inhibitors to target cardiorenal endpoints in patients with and without T2DM, Evaluate safety and efficacy results from clinical trials and real-world studies of SGLT2 inhibitors to optimize cardiorenal outcomes in patients with and without T2DM, Incorporate SGLT2 inhibitors, as appropriate, into the care of clinically complex patients with comorbid cardiovascular, renal, and/or metabolic diseases.

Go online to PeerView.com/VJP860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. In this activity, oncology experts explore the potential of the next wave of novel HER2-targeting therapies in various HER2-altered cancers, including breast, gastrointestinal, lung, and other tumors. Watch as the panel share their insights into the data that support therapeutic targeting of HER2 and consider other critical research questions and future directions. Upon completion of this activity, participants should be better able to: Review evidence-based guidelines and expert recommendations regarding HER2 testing and interpretation of results in breast, gastric, colorectal, and non–small cell lung cancers, Evaluate the characteristics, mechanisms of action, and efficacy/safety evidence of established and emerging HER2-targeted agents for the management of patients with advanced HER2-expressing or ERBB2-mutant cancers, Identify novel approaches to overcome mechanisms of resistance to HER2-targeted therapies, Integrate the latest HER2-targeted therapies into individualized treatment plans for patients with advanced HER2-expressing or ERBB2-mutant breast, gastric, colorectal, and non–small cell lung cancers, either in the context of clinical practice or through clinical trial participation.

Go online to PeerView.com/KFY860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. In this activity, Dr. Heather McArthur provides a brief recap of how the emergence of checkpoint inhibitor therapy in TNBC has changed the management of this challenging subtype of breast cancer, and what some of the unanswered questions and controversies are that ongoing research is aiming to answer. Upon completion of this activity, participants should be better able to: Discuss the rationale for use of cancer immunotherapies in the treatment of triple-negative breast cancer (TNBC) specifically and breast cancer more broadly, Assess efficacy, safety, and other key data from clinical trials assessing immunotherapies and immune-based combinations throughout the continuum of TNBC, including in metastatic settings as well as in early-stage disease in neoadjuvant or adjuvant settings, and relevant implications for clinical practice, Evaluate the current and emerging role of immunotherapies in TNBC, nuances of patient selection and treatment integration, biomarker testing when relevant, management of immune-related adverse events, and other practical aspects related to their use in clinical practice, Integrate immune checkpoint inhibitors into treatment plans of patients with TNBC based on latest evidence, indications, recommendations, disease stage, patient and tumor characteristics, and patient needs/preferences.

Go online to PeerView.com/ZYV860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. In this activity, an expert in women’s health discusses current and emerging therapies for endometriosis and uterine fibroids. Upon completion of this activity, participants should be better able to: Summarize the diagnostic evaluation for uterine fibroids and endometriosis including ultrasound, lab tests and other imaging tests, Recognize the benefits and limitations of current and emerging options for medical management of endometriosis and uterine fibroids, Discuss recent clinical data for the management of endometriosis-associated pain and uterine fibroids, Employ strategies to actively integrate current clinical evidence- and practice-based recommendations for the management of patients with endometriosis and uterine fibroids.

Go online to PeerView.com/VCA860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. In this activity, an expert on heart failure discusses strategies for recognizing and diagnosing heart failure in patients, including the role of natriuretic peptides as clinical biomarkers. Upon completion of this activity, participants should be better able to: Review recommendations offered in current evidence-based guidelines intended to encourage early recognition and timely diagnosis of patients with heart failure, Apply diagnostic and therapeutic strategies using BNP and NT-proBNP as clinical biomarkers to guide the care of patients with heart failure, Evaluate evidence-based strategies for identifying and treating heart failure in patients with reduced ejection fraction.

Go online to PeerView.com/QDX860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. In this activity, an expert in infectious diseases discusses guidance for healthcare professionals involved in the treatment of patients with COVID-19. Upon completion of this activity, participants will be able to: Describe the epidemiology and virology of coronavirus disease 2019 (COVID-19), Evaluate patients with suspected COVID-19 infection in accordance with current guidance from the Centers for Disease Control and Prevention (CDC), recognizing that recommendations may be adapted by state and local health departments to respond to rapidly changing local circumstances, Assess the efficacy, safety, and appropriate clinical utilization of current and emerging COVID-19 management and prevention strategies, Employ evidence-based protocols to provide appropriate care for patients with suspected or confirmed COVID-19.

Go online to PeerView.com/RXX860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. In this activity, an expert in pulmonology discusses key issues in the diagnosis and treatment of patients with uncontrolled persistent asthma. Several case vignettes provide insights on assessing phenotype/endotype and eligibility for biologic therapy in these patients, in the context of common comorbidities and other patient-, disease-, and treatment-related factors. Upon completion of this activity, participants should be better able to: Describe the role of the type 2 inflammatory cascade in uncontrolled persistent asthma and the implications for treatment, Evaluate patients with asthma for symptom severity, phenotype/endotype, exacerbation risk, and eligibility for biologic therapies, Employ the latest clinical data on efficacy and safety of biologic therapies to the treatment of patients with uncontrolled persistent asthma, Use strategies to engage patients in shared decision-making to improve outcomes and quality of life.

Go online to PeerView.com/HWV860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. In this activity, an expert discusses the diagnosis and treatment of spinal muscular atrophy in a new era of therapy. Upon completion of this activity, participants should be better able to: Employ current recommendations for screening and diagnosis of patients suspected to have spinal muscular atrophy (SMA), Recognize clinical signs and symptoms associated with early manifestations of SMA from birth to adulthood, Apply current data on the efficacy, safety, and tolerability of approved disease-modifying therapies for SMA from infancy through adulthood, Counsel patients and/or their parents/caregivers regarding the need for ongoing supportive care to optimize treatment outcomes.

Go online to PeerView.com/GVH860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. The recent approval of newer JAK inhibitors and new evidence on emerging JAK-targeting strategies have raised additional questions over optimized treatment selection in myelofibrosis (MF) and awareness of clinical factors that can influence therapeutic selection. Additionally, newer dynamic risk-assessment models have allowed for more precise characterization of this disease at diagnosis and during the treatment course. In the wake of these advances, understanding how to effectively personalize therapeutic management based on the modern diagnostic and risk-assessment tools while ensuring safe usage of JAK inhibitors is crucial to maximizing beneficial patient outcomes in MF. In a recent live webcast, our panel of experts used the latest real-world evidence to confirm the core therapeutic role for JAK inhibitor–based strategies in MF, highlighting modern diagnostic and risk-assessment strategies that have informed an individualized treatment approach. During a unique practicum session, the panel offered practice strategies using real-world case scenarios, walking through selection of JAK inhibitor–based options across the MF disease continuum to improve patient outcomes. Upon completion of this activity, participants should be better able to: Recognize clinical and molecular/mutational features that can be used for diagnosis and risk stratification in myelofibrosis, Review the latest efficacy and safety evidence about approved and emerging JAK inhibitors as well as other targeted therapies in the management of myelofibrosis, Design safe, risk-adapted treatment regimens for patients with symptomatic and asymptomatic myelofibrosis, including those refractory to front-line JAK inhibitor therapy.