Affecting over 25 percent of Crohn's disease patients, perianal disease is a persistent and difficult-to-treat condition. Due to its complex management and significant impact on patients' quality of life, a multidisciplinary approach to care is crucial. Here to discuss the management of perianal Crohn’s disease, Dr. Peter Buch is joined by Dr. Benjamin Cohen, Co-Section Head and Clinical Director for Inflammatory Bowel Disease at Cleveland Clinic, and Dr. Stefan Holubar, IBD Surgery Section Chief and Director of Research at Cleveland Clinic.