We're back this week with a collection of monologues! We talk about a Paul Offitt quote, COVID boosters for adults and kids, COVID testing, whether this is a pandemic of the unvaccinated, myocarditis and pericarditis, college campus restrictions, and more!

STAT News Op-Ed: https://www.statnews.com/2021/12/23/at-a-time-when-the-u-s-needed-covid-19-dialogue-between-scientists-francis-collins-moved-to-shut-it-down/

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Today we have a short discussion for you of the MEMOIR study, published in The Lancet Oncology: "Effect of immunotherapy time-of-day infusion on overall survival among patients with advanced melanoma in the USA (MEMOIR): a propensity score-matched analysis of a single-centre, longitudinal study". We also have a special treat for you: a lecture Dr. Chris Booth of Queen's University, Kingston, Ontario, Canada recently gave titled "The Emperor Has No Clothes", a critique of the current state of cancer care.

MEMOIR: doi.org/10.1016/S1470-2045(21)00546-5

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Today we have an in-depth, in-person interview with Dr. John Ioannidis of Stanford University. We ask him: where are we now with COVID-19?

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Dr. Zeb Jamrozik, an infectious disease bioethicist at the Monash Bioethics Centre and the University of Oxford, is back again! We discuss Omicron, travel bans, masks, vaccine mandates, and more.

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David Russler-Germain and Papa Heme join VP to discuss the hottest ASH lymphoma papers: POLARIX and 2 CAR-T trials (ZUMA-7 & BELINDA)

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We have an in-person interview for you today! We sit down with Dr. Adil Daud of UCSF to talk all things melanoma. We cover Tebentafusp, nodal dissection, the Will Rogers phenomenon and the effect of stage migration on clinical trials as imaging advances, adjuvant vs I/O, academic training vs apprenticeship for budding oncologists, and more!

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We're back with a hematology/oncology heavy episode! We talk about oral azacitidine for acute myeloid leukemia (AML) and nelarabine for T-cell acute lymphoblastic leukemia (T-ALL) with Dr. Bernie Marini, a Clinical Pharmacist Specialist in Hematology and Associate Professor at University of Michigan Medicine.

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Today we interview Dr. Bill Hall, Associate Professor of Radiation Oncology and Surgery at Medical College of Wisconsin, on his new paper out now in the Journal of Clinical Oncology titled "Value of Neoadjuvant Radiation Therapy in the Management of Pancreatic Adenocarcinoma".

Neoadjuvant: doi.org/10.1200/JCO.21.01220

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Today we interview Dr. Cody Meissner, Chief of the Division of Pediatric Infectious Disease and Professor of Pediatrics at Tufts University School of Medicine. Dr. Meissner is also a member of the US FDA Vaccine Advisory Committee. We talk about the affect of school closures on the health of children, the evidence base for COVID vaccine mandates in children, and the nuance surrounding all of it.

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Dr. Zeb Jamrozik, an infectious disease bioethicist at the Monash Bioethics Centre and the University of Oxford, is back by popular demand! We talk about the failures, both scientific and ethical, of the COVID-19 pandemic.

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