Oral Nirmatrelvir–Ritonavir for Covid-19 in Higher-Risk Outpatients

* Real-World Effectiveness of Nirmatrelvir–Ritonavir Against Severe Outcomes of COVID-19 in Taiwan: A Nationwide Population-Based Cohort Study

Three Low-Dose Antihypertensive Agents in a Single Pill after Intracerebral Hemorrhage

* Effect of Combination Therapy on Adherence Among US Patients Initiating Therapy for Hypertension: a Cohort Study

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RSV Prefusion F Vaccine for Prevention of Hospitalization in Older Adults

Ultrasound-Facilitated, Catheter-Directed Fibrinolysis for Acute Pulmonary Embolism

* Endovascular management of intermediate-risk pulmonary embolism: evidence, outstanding questions, drivers of utilization, and the horizon

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Dengue Suppression by Male Wolbachia-Infected Mosquitoes

* World Mosquito Program

Antibiotic Therapy for Uncomplicated Acute Appendicitis

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* Glucagon-like peptide-1 receptor agonists and risk of substance use disorders among US veterans with type 2 diabetes: cohort study

* Immediate or Deferred Nonculprit-Lesion PCI in Myocardial Infarction

* Andrew’s previous SM post on the subject: How a Meta-Analysis can Mislead—The Story of Complete vs Culprit-only PCI in STEMI

And, a bunch of the other studies we discussed.

* Complete Revascularization with Multivessel PCI for Myocardial Infarction

* FFR-Guided Complete or Culprit-Only PCI in Patients with Myocardial Infarction

* Initial Invasive or Conservative Strategy for Stable Coronary Disease

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Sodium Correction Rates and Associated Outcomes Among Patients With Severe Hyponatremia: A Retrospective Cohort Study

* A Randomized Trial of Targeted Hyponatremia Correction in Hospitalized Patients

Effect of Neuromuscular Warm-up on Injuries in Female Soccer and Basketball Athletes in Urban Public High Schools

* Why Are So Many Teen Girls Still Tearing Their A.C.L.s?

* Injury prevention programs that include plyometric exercises reduce the incidence of anterior cruciate ligament injury: a systematic review of cluster randomised trials

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Most conversations about “AI in Medicine” bore me. I think this is because either we lack the imagination to consider how AI will change medicine in the next decade, or we are not being specific enough about how small parts of medicine could be productively affected.

Dr. Shantanu Nundy, MD, MBA, is a practicing physician whom I like to think of as a serial innovator. He is currently an advisor on artificial intelligence to the FDA in the Commissioner’s Office. He has spent a great deal of time and energy thinking deeply about what AI can bring us today and in the future. I hope you enjoy this conversation.

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High-Dose Influenza Vaccine Effectiveness against Hospitalization in Older Adults

* High-Dose Influenza Vaccine to Reduce Hospitalizations

* Efficacy of high-dose versus standard-dose influenza vaccine in older adults

Beta-blockers after myocardial infarction: effects according to sex in the REBOOT trial

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Today on the podcast, I am joined by Dr. Jennifer Rusiecki. Dr. Rusiecki is an Associate Professor of Medicine at the University of Chicago. She is the Director of Women’s Health and Gender-Based Care in the internal medicine residency program and the assistant clinic director overseeing gender-based care.

Dr. Rusiecki and I discussed the article appraised in the other post today, and also discussed the issues of screening for breast cancer in women with dense breasts and breast cancer screening more generally. Dr. Rusieki and I don’t agree on everything, and you might leave more confused than you came, but I still think it is worth a listen.

Some further reading:

The infographic on mammography we discussed.

A recent article on mammogram quandaries.

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A Conservative Dialysis Strategy and Kidney Function Recovery in Dialysis-Requiring Acute Kidney Injury: The Liberation From Acute Dialysis (LIBERATE-D) Randomized Clinical Trial

Beta-Blockers after Myocardial Infarction with Normal Ejection Fraction

* Should Evidence Come with an Expiration Date?

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No video this week — we had a bit of a computer meltdown — but two interesting articles.

As always, thanks for listening. If you have articles you would like us to cover, please send us a suggestion at [email protected].

This Substack is reader-supported. If you appreciate our work, consider becoming a free or paid subscriber.

This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.sensible-med.com/subscribe