Credits: 0.25 AMA PRA Category 1 Credit™

Overview: In July of 2023, the FDA made a monumental decision to approve Opill, marking the first time an oral contraceptive will be made available without a prescription. The inaugural over-the-counter oral contraceptive is a progesterone-only pill. Join us to discuss the underlying rationales driving this decision and the prospective implications it might have on medical practice as well as women’s health.

Episode resource links:

Biggs, AM, Ralph, L, Morris, N, Ehrenreich, K, Perritt, J, Kapp, N, Blanchard, K, White, K,  Barar, Grossman, RD.

Chen, Q.J. Xiang, W.P. Zhang, D.K., Wang, R.P. Luo, Y.F. Kang, J.Z. Cheng, L.N. Efficacy and safety of a levonorgestrel enteric-coated tablet as an over-the-counter drug for emergency contraception: a Phase IV clinical trial, Human Reproduction, Volume 26, Issue 9, September 2011, Pages 2316–2321, https://doi.org/10.1093/humrep/der181

Raine, TR; Ricciotti, N; Sokoloff, A; Brown, B; Hummel, A; Harper, C. An Over-the-Counter Simulation Study of a Single-Tablet Emergency Contraceptive in Young Females. Obstetrics & Gynecology 119(4):p 772-779, April 2012. | DOI: 10.1097/AOG.0b013e31824c0aed

https://www.fda.gov/news-events/press-announcements/fda-approves-first-nonprescription-daily-oral-contraceptive

https://www.accessdata.fda.gov/drugsatfda_docs/nda/2023/017031Orig1s041SumR.pdf

Guest: Susan Feeney, DNP, FNP-BC, NP-C

Credits: 0.25 AMA PRA Category 1 Credit™

Overview: Listen in as we review a recent JAMA publication of a randomized controlled trial that quantified the benefits of a targeted approach to prescribing antihypertensive medications. Don’t miss this opportunity to keep your management of patients with hypertension up to date.

Episode resource links:

• Sundström J, Lind L, Nawrouzi S, et al. Heterogeneity in blood pressure response to 4 antihypertensive drugs: a randomized clinical trial. JAMA. Published April 11, 2023. doi:10.1001/jama.2023.3322

Guest: Robert A. Baldor MD, FAAFP

Credits: 0.25 AMA PRA Category 1 Credit™

Overview: Depression and anxiety rates are escalating, with a 36% increase in suicide cases between 2018 and 2021, as reported by the CDC. This distressing trend can be attributed to various significant stressors that have arisen in recent times, such as pandemic-related illness and isolation. Medications alone are not as effective as when other modalities are incorporated into the treatment regime. Recent meta-analysis has revealed a strong correlation between engaging in physical activity and reducing suicidal ideation across all levels. Listen in as we discuss these findings and explore practical strategies for their implementation in your clinical practice.

Episode resource links:

• Vancampfort, D., Hallgren, M., Firth, J., Rosenbaum, S., Schuch, F. B., Mugisha, J., Probst, M., Van Damme, T., Carvalho, A. F., & Stubbs, B. (2017). Physical activity and suicidal ideation: a systematic review and meta-analysis. Journal of Affective Disorders. https://doi.org/10.1016/j.jad.2017.08.070

Guest: Susan Feeney, DNP, FNP-BC, NP-C

Credits: 0.25 AMA PRA Category 1 Credit™

Overview: In this episode, we dive into a recent systematic review and meta-analysis confirming the association between cannabidiol (CBD) use and hepatotoxicity. Gain a deeper understanding of clinical applications and the delicate balance of risks and benefits when discussing CBD use with your patients.

Episode resource links:

• Lo LA, Christiansen A, Eadie L, Strickland JC, Kim DD, Boivin M, Barr AM, MacCallum CA. Cannabidiol-associated hepatotoxicity: A systematic review and meta-analysis. J Intern Med. 2023 Mar 13. doi: 10.1111/joim.13627. Epub ahead of print. PMID: 36912195.

Guest: Jillian Joseph, MPAS, PA-C

Credits: 0.25 AMA PRA Category 1 Credit™

Overview: Listen in as we explore the connection between asthma and cancer. We examine new Global Initiative for Asthma (GINA) guidelines and recent observational data correlating an asthma diagnosis with an increased cancer risk. Don't miss out on this essential discussion that will empower you with valuable knowledge for enhanced patient care.

Episode resource links:

• Guo, Y, Bian, J, Chen, Z, et al. Cancer incidence after asthma diagnosis: Evidence from a large clinical research network in the United States. Cancer Med. 2023; 00: 1- 7. doi:10.1002/cam4.5875

Guest: Robert A. Baldor MD, FAAFP

Credits: 0.25 AMA PRA Category 1 Credit™

Overview: There has been uncertainty as to the best time for patients to take blood pressure medications. Tune in as we review the Treatment in Morning versus Evening (TIME) study, which assessed whether morning or evening dosing improves cardiovascular outcomes.

Episode resource links:

• Mackenzie IS, Rogers A, Poulter NR, et al. Cardiovascular outcomes in adults with hypertension with evening versus morning dosing of usual antihypertensives in the UK (TIME study): a prospective, randomised, open-label, blinded-endpoint clinical trial. Lancet. 2022;400(10361):1417-1425. 

Guest: Alan M. Ehrlich MD, FAAFP

Credits: 0.25 AMA PRA Category 1 Credit™

Overview: In 2020, the National Asthma Education and Prevention Program (NAEPP) updated its guidelines for asthma management, incorporating significant changes. This marked the first update since 2007. A recent study revealed that >280 providers of the new asthma guidelines had an average knowledge score of <45%, indicating that these guidelines have likely not been fully incorporated into their practice. We invite you to join us as we discuss the new guidelines and explore strategies for integrating them into your practice.

Episode resource links:

Cloutier MM, Dixon AE, Krishnan JA, Lemanske RF, Pace W, Schatz M. Managing Asthma in Adolescents and Adults: 2020 Asthma Guideline Update from the National Asthma Education and Prevention Program. JAMA. 2020;324(22):2301–2317. doi:10.1001/jama.2020.2197   https://jamanetwork.com/journals/jama/article-abstract/2773482

https://www.jacionline.org/programs_abstracts

https://www.healio.com/news/primary-care/20230225/physicians-show-lack-of-knowledge-on-latest-updates-to-asthma-management-guidelines

Cloutier MM, Teach, SJ., Lemanske RF, Blake KV. The 2020 Focused Updates to the NIH Asthma Management Guidelines: Key Points for Pediatricians. PEDIATRICS Volume 147, number 6, June 2021:e2021050286; https://publications.aap.org/pediatrics/article/147/6/e2021050286/180305/The-2020-Focused-Updates-to-the-NIH-Asthma?autologincheck=redirected

GINA Guidelines: https://ginasthma.org/pocket-guide-for-asthma-management-and-prevention/

Pocket Guide: https://ginasthma.org/wp-content/uploads/2022/07/GINA-2022-Pocket-Guide-WMS.pdf

Guest: Susan Feeney, DNP, FNP-BC, NP-C

Credits: 0.25 AMA PRA Category 1 Credit™

Overview: In this episode, we review recent updates from the Diabetes Prevention Program (DPP) trial and Diabetes Prevention Program Outcomes Study (DPPOS). Join us as we discuss the impact of the updates on diabetes prevention strategies for cardiovascular outcomes.

Episode resource links:

• Goldberg RB, Orchard TJ, Crandall JP, Boyko EJ, Budoff M, Dabelea D, Gadde KM, Knowler WC, Lee CG, Nathan DM, Watson K, Temprosa M; Diabetes Prevention Program Research Group*. Effects of Long-term Metformin and Lifestyle Interventions on Cardiovascular Events in the Diabetes Prevention Program and Its Outcome Study. Circulation. 2022 May 31;145(22):1632-1641. doi: 10.1161/CIRCULATIONAHA.121.056756. Epub 2022 May 23. PMID: 35603600; PMCID: PMC9179081.

Guest: Jillian Joseph, MPAS, PA-C

Credits: 0.25 AMA PRA Category 1 Credit™

Overview: It can be tricky to navigate conflicting data when discussing alcohol intake with patients, so we’re here to discuss the topic’s most recent evidence. In this episode, we take a look at the findings to help you and your patients make informed decisions about daily alcohol consumption and their health.

Episode resource links:

• JAMA Network Open. 2023;6(3):e236185. doi:10.1001/jamanetworkopen.2023.6185

Guest: Robert A. Baldor MD, FAAFP

Credits: 0.25 AMA PRA Category 1 Credit™

Overview: Tune in as we discuss the potential consequences of perceived stress on the cognition and well-being of older adults. We explore screening and intervention opportunities to better help you recognize and manage stress in your patients aged ≥45 years.

Episode resource links:

• Kulshreshtha, A., Alonso, A., McClure, L. A., Hajjar, I., Manly, J. J., & Judd, S. (2023). Association of Stress With Cognitive Function Among Older Black and White US Adults. JAMA network open, 6(3), e231860. https://doi.org/10.1001/jamanetworkopen.2023.1860

Guest: Jill M. Terrien PhD, ANP-BC