We're back!

Fun, quick episode this week. 

https://pubmed.ncbi.nlm.nih.gov/33934725/

Harold Weiss 1, Jacob Dougherty 2, Charles DiMaggio 3

Today's episode is a very complicated topic without clear cut benefits. Expert opinions and modeling data to address a dangerous and serious topic. Let's look at 2 sources: a new study from the Annals of Internal Medicine and an expert opinion from Uptodate.

https://www.uptodate.com/contents/selecting-adult-patients-with-lower-extremity-deep-venous-thrombosis-and-pulmonary-embolism-for-indefinite-anticoagulation?search=unprovoked%20dvt§ionRank=1&usage_type=default&anchor=H648618&source=machineLearning&selectedTitle=1~150&display_rank=1#H648618

vs.

https://pubmed.ncbi.nlm.nih.gov/37364263/

Faizan Khan 1, Doug Coyle 2, Kednapa Thavorn 3, Sasha van Katwyk 4, Tobias Tritschler 5, Brian Hutton 6, Grégoire Le Gal 7, Marc A Rodger 8, Dean A Fergusson 9

Time restricted eating vs. caloric restriction. Is there a winner in this 1:1:1 12-month trial from Chicago?

https://pubmed.ncbi.nlm.nih.gov/37364268/

Talking about 2 studies released last month:

1. Giving it to 3rd trimester moms and seeing what happens in newborns:

https://pubmed.ncbi.nlm.nih.gov/37018474/

2. Giving it to 60+ yo adults and seeing what happens:

https://pubmed.ncbi.nlm.nih.gov/37018468/

What happens when I review these? Listen to find out!

Helpful table (Not sure if this will reproduce well or not):

Hey everyone, on today's episode we are talking about a recent JAMA article on Heterogeneity in Blood Pressure Response to various blood pressure medicines and the idea of individualizing antihypertensive algorithms.

https://jamanetwork.com/journals/jama/article-abstract/2803518

Today's episode we look at a study of 60+ year olds who have poorly controlled depression.  Is it better to add on medications? Switch medications? Does it matter? 

Study link:

https://pubmed.ncbi.nlm.nih.gov/36867173/

Bempedoic Acid aka Nexletol has a new trial in NEJM that shows MACE reduction in very high risk patients (mostly secondary but some primary prevention).  NNT? NNH? Other trials on Bempedoic acid? Tune in and find out.

Interesting study today that looks at High dose ICS inhalers possibly have worse outcomes in patients than medium dose ICS inhalers, leading to more exacerbations and need for antibiotics. Plausible? Let's discuss!

We take a Pre-operative study from the Annals of Surgery and talk about perioperative risk management for patients with low serum creatinine.