During 28 months of follow-up, absolute risks for progression from CIN2 to CIN3 (or worse) were as follows:

Krog L et al. Risk of progression of cervical intraepithelial neoplasia grade 2 in human papillomavirus–vaccinated and unvaccinated women: A population-based cohort study. Am J Obstet Gynecol 2023 Dec 30; [e-pub]. (https://doi.org/10.1016/j.ajog.2023.11.1235. opens in new tab)

>10% unintentional weight loss is most likely associated with 

Wang Q-L et al. Cancer diagnoses after recent weight loss. JAMA 2024 Jan 23/30; 331:318. (https://doi.org/10.1001/jama.2023.25869)

PDE5i are bad if your health if you have cardiovascular disease and a provider that didn't read the paper and only looked at the abstract. Go ahead and write for PDE5i for your patients that need it and do not change your practice based on this study. 

https://www.sciencedirect.com/science/article/pii/S0735109723080749?via%3Dihub#mmc1

Doxy 100mg BID x7days for chlamydia- and consider treating the partner unless you live in West Virginia. 

https://www.cdc.gov/std/treatment-guidelines/chlamydia.htm

Overall incidence of zoster (defined as the presence of the specific diagnostic code in the medical record, accompanied by a prescription for acyclovir) was lower among vaccine recipients, with vaccine protective efficacy estimated to be 64% after a single dose and 76% after two doses.



Zerbo O et al. Effectiveness of recombinant zoster vaccine against herpes zoster in a real-world setting. Ann Intern Med 2024 Jan 9; [e-pub]. (https://doi.org/10.7326/M23-2023. opens in new tab)

• Compared with complication rates in the National Lung Screening Trial, this real-world study had approximately twice the rate of procedural complications (31% vs. 18%) and major complications (i.e., acute respiratory failure, lung collapse or cardiac arrest; 21% vs. 9%).

Rendle KA et al. Rates of downstream procedures and complications associated with lung cancer screening in routine clinical practice: A Retrospective Cohort Study. Ann Intern Med 2024 Jan; 177:18. (https://doi.org/10.7326/M23-0653. opens in new tab)

Ask about and stop aspirin in patients taking it for primary prevention


Li DK et al. Trends in upper gastrointestinal bleeding in patients on primary prevention aspirin: A nationwide emergency department sample analysis, 2016–2020. Am J Med 2023 Dec; 136:1179. (https://doi.org/10.1016/j.amjmed.2023.08.010)

At 25yrs the odds of still having your appendix if you were initially managed nonoperatively was 60%.

https://jamanetwork.com/journals/jamasurgery/article-abstract/2808133

Although an observational trial, it appears lactated ringers is better than normal saline for those individuals with acute pancreatitis to prevent organ failure or local complications. 

https://journals.lww.com/ajg/fulltext/2023/12000/lactated_ringers_use_in_the_first_24_hours_of.29.aspx

2300 steps daily was needed to decrease cardiovascular-related mortality. 4000 steps daily decreased all-cause mortality. Each additional step seem to lower mortality risk. 

https://pubmed.ncbi.nlm.nih.gov/37555441/#:~:text=Conclusion%3A%20This%20meta%2Danalysis%20demonstrates,2337%20steps%20for%20CV%20mortality.