In this episode Lewis First, MD, MS, FAAP, editor-in-chief of Pediatrics, is back for another edition of “First Up.” He joins hosts David Hill, MD, FAAP, and Joanna Parga-Belinkie, MD, FAAP, with a bird’s-eye view of what’s in the December issue of the journal. The hosts also talk to Natella Rakhmanina, MD, AAHIVS, PhD, chair of the AAP Committee on Pediatric AIDS, about World AIDS Day and the global effort to eradicate the disease.