Imagine intentionally eating an allergen to re-teach your immune system to overcome this allergy? That's what our CHOP Allergists are doing in the Oral Immunotherapy Program and it is life changing science in practice! In this episode, Antonella Cianferoni, MD, PhD, explains oral immunotherapy including the immunologic process, the logistics for patients, and managing the risk of anaphylaxis. A great episode for providers and families!

Less well known that SIDS, SUDC is a category of death for a child 12 months of age or older that remains unexplained after a thorough investigation. In this episode, Richard Goldstein, MD, Director of the Roberts Program on Sudden Unexplained Death in Pediatrics and Associate Professor of Pediatrics at Harvard Medical School, teaches us more about SUDC including possible causes, how to navigate this diagnosis with families, and where the research is leading us. 

A special surprise guest joins us for the 200th episode anniversary! In this episode we explore why CHOP started a medical education podcast, how topics/guests are chosen, and what impact the podcast has had on listeners. Get behind-the-scenes with host and creator, Katie Lockwood, MD, MEd, and learn about the important role of podcasting in medical education. 

This year the Children's Hospital of Philadelphia (CHOP) Poison Control Center celebrates it's 40th anniversary! In this episode, Fred Henretig, MD, one of the founders of the Poison Control Center reviews the history of how the Center came to be and it's role in keeping children safe and healthy in 2025. Robert Bassett, DO, teaches us about how the Poison Control Center operates and what the most common poisoning threats are today and how to prevent them. Meanwhile, Katie Lockwood, MD, MEd, shares that her family has called, so make sure you have 1-800-222-1222 saved in your phone and listen to this fascinating episode for more tips on poison prevention!

Dengue fever is a mosquito-borne viral illness that can have serious complications. In this episode, Lori Handy, MD, MSCE, an attending in the Division of Infectious Diseases and Associate Director of the Vaccine Education Center at CHOP, explains the symptoms of dengue, why the vaccine is uncommonly used, and how to manage fever in a returning traveler. With half of the world's population living where dengue is common, this is an important infection for us to all know about and keep on the differential!

Marijuana use by teens has been stable over the past few decades with 1 in 5 high schoolers using marijuana regularly. However, THC levels in marijuana have increased and we are seeing more Cannabis Hyperemesis Syndrome (CHS). In this episode, Adam Kronish, MD, explains current trends in marijuana use, the physiology of CHS, and what we can do in primary care to identify and manage this condition. 

Delivering serious news is unfortunately a part of pediatrics. While some believe that we are inherently either good or bad at this skill, we know that is not true and that you can learn how to do this well. In this episode, Julie W. Stern, MD, the Director of Outreach Services with the Division of Oncology at Children's Hospital of Philadelphia, shares best practices and lessons learned from years of having difficult conversations. 

Tzield or Teplizumab, is a CD3-directed monoclonal antibody to delay the onset of Stage 3 Type 1 Diabetes in adults and pediatric patients aged 8 years and older. This is an important new treatment option because when diabetes is recognized in the early stages (Stage 2), there is an approved treatment that has been shown to delay the need for insulin by about 2-3 years. In this episode, Neha S. Patel, DO, who is an Associate Professor of Pediatrics and an attending physician in the Division of Pediatric Endocrinology and Diabetes at Children's Hospital of Philadelphia, teaches us what we need to know about Tzield and how patients can access it. 

Jessi Gold, MD, MS, shares some of the lessons from her book, How Do You Feel: One doctor's search for humanity in medicine, including managing emotions, addressing burnout, and exploring self-identity. This episode feels like self-care! Learn the difference between secondary trauma, burnout, PTSD, and why healthcare workers are particularly at risk for experiencing trauma. Dr. Gold not only explores the current state of healthcare worker mental health but gives actionable ideas to help the helpers!

Paul Tran, MD, a pediatric gastroenterologist and medical educator, empowers and encourages medical learners through his comedic online medical education, using the handle @alimentaryschool. Listen as we discuss how he got started, the anatomy of a post, and how to respond to online criticism. In addition, we hear about his viral posts and why he's always carrying a notebook.