In this episode, Juhee Lee, MD, an attending physician in the Division of Allergy and Immunology at CHOP, discusses some of the nuanced ways anaphylaxis can present and reviews the diagnostic criteria for anaphylaxis. We use a few cases to apply the diagnostic criteria to real-world challenges and discuss how to manage patients with anaphylaxis in the outpatient setting. Dr. Lee teaches us about what's new in anaphylaxis treatment, including intranasal epinephrine, and when patients need to carry epinephrine auto-injectors. Lastly, we review the CHOP Clinical Pathway for the Evaluation/Treatment of Children with Anaphylaxis, which is a great resource.