RH factor in pregnancy and RhD alloimmunization in pregnancy. What happends when a patient has RH negative blood during prengnacy and what happends when alloimmunization takes place.

RhD-negative patients who deliver an RhD-positive newborn or who are otherwise exposed to RhD-positive red blood cells are at risk of developing antibodies which can leadd to alloimmunization. This primarily affects a subsequent pregnancy if the patient is exposed to RhD positive blood during the pregnancy or labor.

If the next pregnacy has a RhD-positive fetuses, that pregnancy is at risk for developing hemolytic disease of the fetus and newborn (HDFN), which can be associated with serious fetal anemia and fetal hydrops.

This episode reviews the importance of the Rh factor in pregnancy.

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