This Oncology PER®Spectives™ podcast explores the role of EZH2 in metastatic castration-resistant prostate cancer (mCRPC) progression and its synergy with androgen receptor inhibitors. In this podcast, experts Neeraj Agarwal, MD, FASCO; Himisha Beltran, MD; and Maha Hussain, MD, FACP, FASCO, discuss the management of mCRPC.

This activity is supported by an educational grant from Pfizer Inc.

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Today’s faculty are:

Professor of Medicine

Senior Director for Clinical Research

HCI Presidential Endowed Chair of Cancer Research

Director, Center of Investigational Therapeutics

Director, Genitourinary Oncology Program

Huntsman Cancer Institute, University of Utah (NCI-CCC)

Salt Lake City, UT

Disclosures: Grant/Research Support (paid to institution): Arvinas, Astellas, AstraZeneca, Bayer, Bristol Myers Squibb, Calithera, Celldex, Clovis, Crispr, Eisai, Eli Lilly, EMD Serono, Exelixis, Genentech, Gilead, GlaxoSmithKline, Immunomedics, Janssen, Lava, Merck, Nektar, Neoleukin, Novartis, Oric, Pfizer, Roche, Sanofi, Seagen, Takeda, Tra-con

Associate Professor of Medicine

Director of Translational Research Within Medical Oncology

Harvard Medical School

Lank Center for Genitourinary Oncology and the Division of Molecular

and Cellular Oncology

Dana Farber Cancer Institute

Boston, MA

Disclosures: Grant/Research Support: Circle Pharma, Daiichi Sankyo, Novartis; Adviser: Amgen, AstraZeneca, Daiichi Sankyo, Novartis

Genevieve E. Teuton Professor of Medicine

Professor, Medicine (Hematology/Oncology)

Deputy Director

Robert H. Lurie Comprehensive Cancer Center

Northwestern University Feinberg School of Medicine

Chicago, IL

Disclosures: Advisory Board: AstraZeneca, Bayer, Convergent Therapeutics, Honoraria: AstraZeneca, Bayer

The staff of Physicians’ Education Resource®, LLC, have no relevant financial relationships with ineligible companies.

PER® mitigated all COI for faculty, staff, and planners prior to the start of this activity by using a multistep process.

This activity may or may not discuss investigational, unapproved, or off-label use of drugs. Learners are advised to consult prescribing information for any products discussed. The information provided in this accredited activity is for continuing education purposes only and is not meant to substitute for the independent clinical judgment of a health care professional relative to diagnostic, treatment, or management options for a specific patient’s medical condition. The opinions expressed in the content are solely those of the individual faculty members and do not reflect those of PER® or any company that provided commercial support for this activity.

May 14, 2025

May 14, 2026