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Roger Green conducts one-on-one interviews with Stephen Harrison and Alina Allen to explore specific issues regarding new issues and insights for clinical research and drug development resulting from the work of Dr. Allen and her colleagues.

Stephen Harrison discusses the important contribution this paper makes to our knowledge about disease progression. He then suggests several types of studies and issues that are likely to progress from this research and closes by focusing on its immense value for cirrhotic patients and medications. Alina Allen discusses her vision of how both research and treatment might evolve as researchers learn more about the interplay of different types of diagnostic testing in both research and clinical settings.