Surfing the MASH Tsunami

S4-E18.4 - Empowering Physicians Through Simple Tools and the Demise of Beethoven


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As part of our ongoing dialogue around clinical care pathways and the complex of metabolic diseases, SurfingNASH dedicates a session to focus on the key relationship and interplay between endocrinology and hepatology. This topic rings familiar in the Rising Tide series, our podcast for frontline education, where Ken Cusi often notes the need for endocrinologists to become comfortable diagnosing Fatty Liver disease (and prescribing pioglitazone) and for hepatologists to become more comfortable prescribing GLP-1s. To expand on these critical ideas with the SurfingNASH community, Jörn Schattenberg, Louise Campbell and Roger Green are joined by Cyrielle Caussy, Professor of Nutrition and Endocrinologist-Diabetologist at Lyon 1 University and Lyon South Hospital, Hospices Civils de Lyon (France). Cyrielle is an expert in the clinical care of metabolic disease, including type 2 diabetes, obesity and NAFLD, and she is leading a clinical and research program focused on metabolic liver disease at the Lyon Hepatology Institute.

Louise leads this conversation with a question around designing a more comprehensive metabolic blood profile in light of the vastness of metabolic syndrome and diseases. Jörn responds that while a metabolic screening would be of strong research interest, the message discussed in this episode champions simplicity, practicality and the ability to empower physicians for the identification and risk stratification of their patient population. From here, Cyrielle describes discovering patients with NAFLD-driven diabetes and the implications that various subtypes have on disease prognosis.

Jörn takes an amusing turn to a recently published article in Nature which points to liver disease, viral hepatitis and alcohol consumption as causes of the composer Beethoven’s demise. Tune in to the full conversation to learn more about this unique case.

If you enjoy the episode, have questions or interest around endocrinology and Fatty Liver disease, we kindly ask that you submit reviews wherever you download the discourse. Alternatively, you can write to us directly at [email protected].

Stay Safe and Surf On!


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