In this month's Point/Counterpoint editorials, Najib M. Rahman, DPhil, takes the "yes" side of the debate, arguing that pleural infection continues to result in significant morbidity and mortality despite current therapeutic strategies. He joins CHEST Podcast Editor, D. Kyle Hogarth, MD, FCCP, and Gene Colice, MD, FCCP, who takes on the "no" position. Dr. Colice argues that dosing regimens for fibrinolytics do not ensure effective intrapleural fibrinolysis, clinical trials in adults have not shown consistent clinical benefits, and an alternative approach (surgical drainage by video-assisted thoracoscopic surgery) provides effective drainage of the pleural space with improved clinical outcomes.