What happens when a deep-seated thirst for childhood revenge turns into a career in genetic engineering? You get an absolute badass who is plotting the ultimate downfall of the world's deadliest killer. Krystal is a Ugandan entomologist (aka a massive bug nerd) who has dedicated her life to taking down the mosquito. Growing up in Uganda, surviving malaria was basically a terrifying game of Russian roulette. Crystal shares the raw, heart-wrenching origin story that fueled her career: watching her little brother suffer through brutal, fever-induced seizures all night while her family simply couldn't afford the medication to treat him. Crystal completely schools Jeremie and Brian on what malaria actually does to the human body - and it is no joke. We're talking brain damage from cerebral malaria, "black water fever" (where your urine turns black from liver damage), and even gangrene that leads to amputations. We also dig into the wild fact that out of the 3,500 species of mosquitoes on Earth, only about four are the real assholes responsible for the vast majority of malaria transmission in Africa. This episode is a massive reality check about the devastating barriers to healthcare in the developing world, the literal life-saving impact of the Global Fund, and the badass science that might just eradicate this disease for good. Grab your bug spray and tune in.

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What happens when the doctor treating you is a cold, calculating AI trained on the deepest, darkest, most biased corners of the internet? This week, the boys sit down with Dr. Justin C. Key, a real-life psychiatrist and horror author who is literally writing the book on our medical doom. His new sci-fi thriller, The Hospital at the End of the World, explores the terrifying intersection of artificial intelligence and medicine. Justin joins us to unpack the big, messy questions: Is AI going to save a broken healthcare system, or is it just acting as a shiny digital band-aid for exhausted doctors who don't have the time to actually show up for their patients? We dive deep into the fascinating world of the placebo effect and why simply being seen and heard by a flawed, flesh-and-blood human is a crucial part of the healing process. Justin shares why he absolutely refuses to let AI write his clinical notes, arguing that the act of sitting down and thinking about the session is the real work. 

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What happens when your internal monologue switches from a storybook narrator to a demonic bully at age 12? Live from downtown Halifax, the guys sit down with Melly, a student association president who perfectly masked severe ADHD until a shocking diagnosis at age 43. Before finding out how her brain actually worked, Melly spent her 20s and 30s chasing dangerous dopamine hits just to make that inner voice shut up. We’re talking drinking seven days a week , regularly going home with strangers , and hopping right back into a truck bed the day after a drunk driver flipped it and nearly killed her. She even moved to Malaysia for a decade to teach scuba diving, purely because being deep underwater was the only place she could find true, beautiful silence. Melly gets brutally honest about the decades of self-love she lost to internal misery , using her role in student government to check on the peers who look completely fine but are privately drowning , and how her neurodivergence gave her the absolute fearlessness to solo-travel the globe. 

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What would you do if you moved out to LA at 18 to chase your dreams, but got handed a non-Hodgkin's lymphoma diagnosis and a 5-year expiration date instead? Our guest Aria fought through chemo, radiation, and 16 separate surgeries, and actually beat it. But the universe wasn’t done with her. After just two months of remission, the cancer moved to the temporal lobe of her brain, and doctors gave her one year to live. Spoiler alert: she didn't die. Aria decided to surrender to whatever was going to happen and somehow beat terminal brain cancer. But just when she thought she was in the clear, celebrating her one-year cancer-free anniversary on a road trip to Wyoming, she passed out at the wheel and crashed her car at 80 mph. The impact shattered her occipital bone, essentially detaching her skull from her spine. She woke up completely blind, unable to speak, and unable to walk. Buckle up (literally and figuratively) for a real life Final Destination style episode. Aria is a radiant, unkillable badass, and this conversation is a masterclass in fearless resilience.  

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This week on Sickboy we bring you the first episode of the latest season of Breathless. We're proud as heck with how this panned out and feel like you will dig it! The Season 2 premiere of Breathless explores a biological and existential revolution. For decades, Cystic Fibrosis was defined by a "physical perimeter"—a list of things that were simply impossible. But with the advent of transformative drugs like Trikafta, those walls are vanishing. Host Jeremie opens with a visceral comparison between a 2017 spiritual "holotropic breathing" experience and the 2021 pharmaceutical miracle of his first dose of Trikafta. We then hear from elite athletes who shattered expectations long before the "miracle drug" existed, and we look at how Cystic Fibrosis Canada is pivoting its entire mission from "extending life" to supporting a life "without limits."

What if you could turn off the most agonizing pain imaginable just by thinking about a waterfall? Or better yet, what if a guy in a purple silk robe could cure you by waving a magnet over your junk? This week, Jeremie takes Brian and Taylor on a wild, mind-bending trip into the billion-dollar industry of Hypnobirthing and the dark, bizarre history of hypnosis. From 18th-century "Animal Magnetism" and the accidental discovery of the placebo effect, to a 19th-century surgeon who removed 80-pound scrotal tumors while his patients literally slept through it, we’re unpacking whether the brain really has a 'mute button' for pain. Is hypnobirthing tapping into a dormant superpower of the human mind, or is it just the ultimate medical gaslight that leaves women trapped in a toxic 'shame spiral' when it hurts? Grab your pocket watch, protect your testicles, and let's get weird.

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What do you do when a life-saving medical breakthrough saves almost everyone in your chronic illness community—except you? If you’re new to the show, Cystic Fibrosis is traditionally known as a genetic disease that heavily impacts the lungs. But this week, the fellas sit down with Nicholas Kelly, a registered dietitian who playfully calls himself a "unicorn" because he’s a Black man living with a condition stereotypically labeled as a pasty white person's illness. (Oh, and Taylor passed out right before we hit record, so he’s currently sleeping off-set while Brian stands by with his historically rib-shattering CPR skills) . Nick opens up about his mother bucking the 1980s medical establishment to diagnose him at three months old , outliving a massive string of childhood expiration dates , and surviving an actual "code blue" post-surgery nightmare. He also drops a beautifully perspective-shifting bomb on the room about what it truly feels like to watch his closest friends get saved by the miracle drug Trikafta while his own rare genetic mutations leave him completely ineligible for the club. From highly inappropriate anatomy questions to a profound psychological transition from chasing the clock to building a legacy , this episode is an incredible look at what it means to live life with absolute passion.

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What do you do when your own immune system decides to treat your organs like an all-you-can-eat buffet and drops eight separate medical diagnoses on your lap? This week, the brilliant and unapologetically defiant Jennifer Park joins the fellas to tier-rank her massive collection of interlocking illnesses. From competitive pro bodybuilding while navigating liver cirrhosis, to sneaking a giant wooden shower brush into high-level executive meetings just to fight off a systemic itch that literally feels like bugs under her skin, Jennifer is the ultimate biological overachiever. She gets hilariously raw about surviving a catastrophic colostomy bag explosion inside a crowded university bathroom, flying down to Texas for experimental exosome treatments, and the verbal smackdown she gave a snarky transplant surgeon who tried to flex a god complex on her.

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What happens when the person keeping you alive is also the person roasting your life choices the hardest? If you’re new to the show, Brock is our brilliant, hilarious resident intern who navigates life with Cerebral Palsy. But this week, we’re turning the spotlight on the real hero of his life. His long-term care worker (and for sure NOT his wife) Katherine, joins the fellas to talk about the chaotic, beautiful, and hilariously messy reality of being a Personal Support Worker (PSW). From catastrophic bladder blunders involving white pants and aggressive speed bumps, to asking the highly inappropriate boundary questions everyone else is too polite to touch, this episode is a raw look at what happens when your medical partner feels less like a sterile clinician and more like a cranky old spouse. But again… Not his spouse. 

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What happens when your brain is a literal ticking time bomb and nobody tells you until it goes off? Meet Martin. At 16, he was just a normal kid until a rare brain malformation (AVM) ruptured, sending him into a month-long coma where he "tripped balls" to a Lil Wayne soundtrack provided by the ICU staff. But the rupture was only the beginning. After a grueling months long recovery he got hit with a second rupture, a brain infection, and devestating complications he was left with "Sunken Bone Flap Syndrome". A condition where atmospheric pressure literally pushed his scalp into his brain. It’s a story about hitting rock bottom multiple times and finding the "gains" every single time you climb back out.

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