The Chiropractic Forward Podcast: Evidence-based Chiropractic Advocacy

Spinal Manipulative Treatment And Biochemical Markers & SMT For Lumbar Disc Herniation


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CF 368: Spinal Manipulative Treatment And Biochemical Markers & SMT For Lumbar Disc Herniation Today we’re going to talk about Spinal Manipulative Treatment And Biochemical Markers & SMT For Lumbar Disc Herniation.  But first, here’s that sweet sweet bumper music  

Purchase Dr. Williams’s book, a perfect educational tool and chiropractic research reference for the daily practitioner, from the Amazon store TODAY!

OK, we are back and you have found the Chiropractic Forward Podcast where we are giving evidence-based chiropractic a little personality and making it profitable. We’re not the stuffy, elitist, pretentious kind of research. We’re research talk over a couple of beers. So grab you a bushel.  I’m Dr. Jeff Williams and I’m your host for the Chiropractic Forward podcast.  I’m so glad you’re spending your time with us learning together.  Chiropractors – I’m hiring at my personal clinic. I need talent, ambition, smarts, personality, and easy to get along with associates. If this is you and Amarillo, TX is your speed, send me an email at [email protected] If you haven’t yet I have a few things you should do. 

  • Go to Amazon and check our my book called The Remarkable Truth About Chiropractic: A Unique Journey Into The Research. It’s excellent resource for you and is categorized into sections so the information is easy to find and written in a way that is easy to understand for everyone. It’s on Amazon. That’s the Remarkable Truth About Chiropractic by Jeff Williams. 
  • Like our Chiropractic Forward Facebook page, 
  • Join our private Chiropractic Forward Facebook group, and then 
  • Review our podcast on wherever you listen to it 
  • Last thing real quick, we also have an evidence-based brochure and poster store at chiropracticforward.com
  • You have found yourself smack dab in the middle of Episode #368 Now if you missed last week’s episode, we talked about Transcranial Direct Current for Fibromyalgia & Methotrexate For Knee Osteoarthritis. Make sure you don’t miss that info. Keep up with the class. 

    On the personal end of things….. Things are clicking along this Summer. Still getting back up to steam. We have the big Texas Chiropractic Association ChiroTexpo coming up this weekend in Frisco, TX which is basically Dallas.  This is our state convention. We usually have around 400 or so attendees. Good stuff. It’s a great time to reconnect to old TCA buddies and to connect with the newer, younger group coming up in the Association and some of the newer folks are just brilliant. It’s a joy to see. 

    I’m still involved. I’ve been involved for a long time now on the state level. I’ve been in the seat when we were fighting the Texas Medical Association for our right to diagnose or for our right to keep acupuncture or for our right to keep the Neuro aspect of neuromusculoskeletal…..I’ve been there. And I can tell you that you tend to form a bond with those that are in the seats next to you and across from you when you’re in the middle of these battles.  If you are not involved in your state association or the ACA, I cannot encourage you quite enough to raise your hand and jump in. There are only 25% of chiropractors in the state of Texas that are members of our association.

    But I promise, 100% of them want their rights to practice protected.  That’s a damn promise. Take that to the bank folks.  Well, that’s taking instead of giving, isn’t it? That’s actually the definition of it and, honestly, the apathy in our industry is straight up appalling. Most just don’t know what’s going on in their own profession on a state or a national level.  I can give you time after time when I was able to call my fellow TCA connections and friends and bounce something off of them. Whether it was an idea or a problem. They’ve come through for me a million times.  I had an evidence-based chiro tell me they don’t get involved because they’re state association is all vitalists. Wouldn’t you think that THAT WOULD BE THE PERFECT REASON TO GET INVOLVED?

    Well, is the perfect reason but it was being used as an excuse to continue being a lazy taker rather than a giver.  I get to influence who speaks at our events. Don’t you think that’s important? If you have a ton of vitalists influencing your membership, that’s no bueno mi amigo. But if you have top-notch genius evidence-based chiros speaking, well, I can only imagine that it would make an incredible impact. And it does.  I had a buddy, Dr. Ben Fergus, say something that I thought was just wonderful. He said, “The body responds to force and repetition.” I use that with my patients all day every day now. Because it’s true. I’d say the same goes for changing your profession. Your profession responds to positive forces used repetitively.

    Over time, vitalists will dwindle. They’ll always be amongst us. I’m not a fool. But they will eventually be out of the drivers’ seats and more toward the back of the short bus.  But ONLY if our evidence-based, high-performing doctors get off their asses, get involved, and make it happen. Otherwise, we keep sitting back watching it happen and bitching to each other about it non-stop.  So….this is your call. Google your state association, get the name and contact info for your states executive director and/or executive committee members, then email them and tell them you’d like to get more involved. Raise your hand. They’re desperate for active members. Alright, go google it up and send that email right now, then come back and let’s cover some research!

    Item #1 The first one this week is called ,”Changes in biochemical markers following a spinal manipulation – a systematic review update” by Sampath et al and published in Journal of Manual & Manipulative Therapy in August of 2023.  Remember, the citations can be found at chiropracticforward.com under this episode.  Kovanur Sampath, K., Treffel, L., P.Thomson, O., Rodi, J. D., Fleischmann, M., & Tumilty, S. (2023). Changes in biochemical markers following a spinal manipulation – a systematic review update. Journal of Manual & Manipulative Therapy, 32(1), 28–50. https://doi.org/10.1080/10669817.2023.225218

    Why They Did It The aim of this systematic review was to update the current level of evidence for spinal manipulation in influencing various biochemical markers in healthy and/or symptomatic population.

    How They Did It

    • This is a systematic review update. 
    • Various databases were searched from May 2023 and fifteen trials with 737 participants that met the inclusion criteria were included in the review. 
    • Two authors independently screened, extracted and assessed the risk of bias in included studies. 
    • Outcome measure data were synthesized using standard mean differences and meta-analysis for the primary outcome which were biochemical markers. 
    • The GRADE criteria was used for assessing the quality of the body of evidence for each outcome of interest.
    • What They Found There was low-quality evidence that spinal manipulation influenced various biochemical markers (not pooled).  There was low-quality evidence of significant difference that spinal manipulation is better than control in eliciting changes in cortisol levels immediately after intervention.  Low-quality evidence further indicated (not pooled) that spinal manipulation can influence inflammatory markers such as interleukins levels post-intervention. There was also very low-quality evidence that spinal manipulation does not influence substance-P, neurotensin, oxytocin, orexin-A, testosterone and epinephrine/nor-epinephrine.

      Wrap It Up Spinal manipulation may influence inflammatory and cortisol post-intervention. However, the wider prediction intervals in most outcome measures point to the need for future research to clarify and establish the clinical relevance of these changes.

      Item #2

      Our last one this week is called, “Brain plasticity following lumbar disc herniation treatment with spinal manipulation therapy based on resting-state functional magnetic resonance imaging” by Du et al and published in Heliyon in September of 2024 and that’s just hot enough! https://www.cell.com/heliyon/fulltext/S2405-8440(24)13734-6

      Why They Did It As a prevalent spine disorder, Lumbar disc herniation (LDH) has been affecting more than 2 % of the worldwide population and is characterized by uncertain causes and recurring episodes.  Studying the brain activity of patients could potentially provide insights into its pathogenesis and significantly enhance therapy.  Therefore, we here examined brain function in patients under Spinal Manipulative Therapy (SMT).  By analyzing regional homogeneity (ReHo) at different frequency bands, we identified the discrepancies in brain activity between LDH patients and healthy people, highlighting the frequency dependence of spontaneous low-frequency oscillations among patients with LDH.

      How They Did It The test subjects underwent a single fMRI scan upon enrollment.  Patients with LDH underwent their initial functional MRI scan after completing the VAS and C-SFODI scales.  They then completed a second assessment of the VAS and C-SFODI scales, along with another fMRI scan, after receiving six adjustments. The clinical evaluation indicators were as follows: 

      1. The VAS was used to assess the patient’s pain level;
      2. The Chinese Short Form Oswestry Disability Index Questionnaire (C-SFODI) was used to evaluate the patient’s functional limitations. 
      3. Wrap It Up

        Overall, this study showed that SMT significantly reduced pain, improved dysfunction, and partially rectified aberrant local consistency and functional connection in patients with LDH, not only offering insights into the pathophysiology of LDH from a neurological standpoint, but also providing inspiration for the development of new therapies based on neurobiology. Alright, that’s it. Keep on keepin’ on. Keep changing our profession from your corner of the world. The world needs evidence-based, patient-centered practitioners driving the bus. The profession needs us in the ACA and involved in leadership of state associations. So quit griping about the profession if you’re doing nothing to make it better. Get active, get involved, and make it happen. Let’s get to the message. Same as it is every week. 

        Store Remember the evidence-informed brochures and posters at chiropracticforward.com.   

        Purchase Dr. Williams’s book, a perfect educational tool and chiropractic research reference for the daily practitioner, from the Amazon store TODAY!

        The Message

        I want you to know with absolute certainty that when Chiropractic is at its best, you can’t beat the risk vs reward ratio because spinal pain is primarily a movement-related pain and typically responds better to movement-related treatment rather than chemical treatments like pills and shots. When compared to the traditional medical model, research and clinical experience show us patients can get good to excellent results for headaches, neck pain, back pain, and joint pain to name just a few. It’s safe and cost-effective can decrease surgeries & disability and we do it through conservative, non-surgical means with minimal hassle to the patient. And, if the patient treats preventatively after initial recovery, we can usually keep it that way while raising the overall level of health!

        Key Point: At the end of the day, patients should have the guarantee of having the best treatment that offers the least harm. When it comes to non-complicated musculoskeletal complaints…. That’s Chiropractic!

        Contact Send us an email at dr dot williams at chiropracticforward.com and let us know what you think of our show and tell us your suggestions for future episodes.  Feedback and constructive criticism is a blessing and so are subscribes and excellent reviews on podcast platforms.  We know how this works by now. If you value something, you have to share it, interact with it, review it, talk about it from time to time, and actively hit a few buttons to support it here and there when asked. It really does make a big difference. 

        Connect We can’t wait to connect with you again next week. From the Chiropractic Forward Podcast flight deck, this is Dr. Jeff Williams saying upward, onward, and forward.

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        About the Author & Host Dr. Jeff Williams – Fellow of the International Academy of Neuromusculoskeletal Medicine (FIANM) and Board Certified Diplomate of the American Board of Forensic Professionals (DABFP) – Chiropractor in Amarillo, TX, Chiropractic Advocate, Author, Entrepreneur, Educator, Businessman, Marketer, and Healthcare Blogger & Vlogger            

        The post Spinal Manipulative Treatment And Biochemical Markers & SMT For Lumbar Disc Herniation appeared first on Chiropractic Forward.

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