David Boies, the lawyer who counseled former Vice President Al Gore in the 2000 election Florida recount, says President Trump will be unable to overturn the 2020 election results. Covid-19 cases are rising with hopes for an effective vaccine. In light of positive news from Pfizer, Moderna, and AstraZeneca, former Aetna CEO Mark Bertolini considers the current plans for managing supply and distribution and offers his own method as an alternative. SEC Chairman Jay Clayton is leaving his post after 3 years. In his exit interview on CNBC, he weighs in on cryptocurrency, the SPAC frenzy, and the next disruptors to the US financial system. 

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As Covid cases rise and states impose new curfews to stem the spread, Pfizer & BioNtech have unveiled their coronavirus vaccine’s final data analysis. Their vaccine proved 95% effective in preventing the coronavirus, higher than preliminary data originally revealed. Former FDA Commissioner and Pfizer board member Dr. Scott Gottlieb discusses the bumpy but significantly shorter road to the end of the pandemic. He addresses next steps for lawmakers, Moderna, and Pfizer as they strategize vaccine supply and distribution. Plus, the Federal Aviation Administration has cleared the Boeing 737 Max to fly again, 20 months after it grounded the aircraft in the wake of two deadly crashes. In a CNBC exclusive interview, FAA Administrator Steve Dickson recounts the plane’s extensive safety reviews, discusses the journey ahead to restore confidence in the aircraft, and addresses concerns about his own agency’s relationship with Boeing. 

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The S&P 500 will finally add Tesla to its index in mid-December. Elon Musk’s electric vehicle company now tops $400B in market cap. Warren Buffett’s Berkshire Hathaway made some changes to its equity portfolio in the last quarter, trimming its stakes in Apple and JPMorgan and betting on drug stocks and T-Mobile. Amazon is jumping into the pharmacy business with online prescription fulfillment and delivery for Prime members. Plus, conservative Americans may be seeking new media platforms; Newsmax CEO Christopher Ruddy responds to reports that his channel is a target for acquisition and defends his editorial perspective. Ruddy explains why his channel has become a Fox News alternative, and considers the prospect of “Trump TV.”

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In Moderna’s ongoing clinical trial, the drugmaker’s Covid vaccine proved 94.5% effective in preventing the coronavirus. In an exclusive interview, CEO Stephane Bancel and CNBC’s Meg Tirrell discuss the news, the bright light at the end of the pandemic tunnel, and ensuring a steady supply of vaccines to those who need it most. Plus, former Citigroup chairman and former Time Warner CEO Richard Parsons considers what the vaccine would mean for American business, what a contested election would mean for the country’s future, and what the pandemic’s disruption to sports and entertainment will mean for media and content providers in the years to come. 

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Social media entrepreneur and venture capitalist Alexis Ohanian urges Americans to consider the role social platforms should play in society. He examines where the Internet started, where it’s going, and how the “levers of power should be wielded.” He and Aylon Steinhart, founder of plant-based ice cream company Eclipse, outline a positive outlook for the startups and entrepreneurs who’ll emerge from the collective trauma and chaos of 2020. Restaurateur Cameron Mitchell operates over 30 establishments across the country, but he needs additional government stimulus to keep his business afloat. Plus, CNBC’s Robert Frank reports that the wealthy are hoping to pay for early access to Covid vaccines, and Elon Musk reports that his own Covid tests are testing his patience. 

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Parler, a new social media platform that touts itself as a less censored alternative to Facebook and Twitter, is rising in popularity, particularly among conservative Americans. The Anti-Defamation League’s Jonathan Greenblatt says Parler’s free speech mission might be leaving too wide an opening for harmful content. Morgan Stanley’s Mike Wilson says this bull market has a long way to run, both in timing and pricing; he offers investors some cautionary advice. Plus, former FDA Commissioner Dr. Scott Gottlieb discusses rising Covid cases and the impact on the health care system across the nation. He considers the risks for Americans hoping to celebrate Thanksgiving in groups.

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In a rare interview, Lyft co-founder and President John Zimmer discusses the ridesharing app’s path to profitability, plans for food delivery (or not), and a post-pandemic boost to business. Plus, the U.S. is celebrating and remembering veterans today; former CIA Director and retired U.S. Army general David Petraeus explains why it’s a good day to thank our servicemen and servicewomen, and an even better time to hire them. General Petraeus examines President-Elect Joe Biden’s campaign promise to “end never-ending wars,” and calls on history and geopolitical practice to imagine a world with less U.S. involvement in international conflict.

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In the wake of Pfizer’s positive vaccine news, markets are rallying on hopes of a light at the end of the pandemic tunnel. BET and RLJ Companies founder Bob Johnson is relieved by the news but looking ahead; he discusses the pandemic’s disproportionate impact on Black Americans, and shares his vision for narrowing the racial health and wealth gap under a new administration. Plus, Target has entered a deal with Ulta Beauty, Amazon is in hot water in the EU, and Tesla is making up for defective computers in some of its vehicles. 

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Ed Clissold, market strategist for Ned Davis Research Group, puts this week’s election in perspective with market and election data going back to 1900. Historically, a Republican incumbent victory prompts a market rally in the short term, but a reversal in the year following. Essayist and “Black Swan” investor Nassim Nicholas Taleb outlined the risks of a pandemic earlier in 2020, and now says the solution is simple, if only governments around the world could move past their coronavirus denial. Taleb - who advises Universa Investments, with 100%+ annual return from 2008-2019 - says victor predictions are a sign of incompetence; his election calculus: 50/50. Plus, Covid-19 cases continue to rise as we head into the holiday season.

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In what Pfizer CEO Albert Bourla calls “likely the most significant medical advancement in the last 100 years,” BioNtech and Pfizer’s Covid-19 vaccine may prove to be more than 90% effective in preventing coronavirus. CNBC’s Senior Health and Science Reporter Meg Tirrell breaks the good news with the Squawk Box anchors, and Pfizer CEO Dr. Albert Bourla discusses the success, the implications, and the questions still unanswered. In an extended interview, Bourla thanks his scientists for their ongoing work to change the course of history and outlines the road ahead. 

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