Today we are joined by Professor Nick James, Principal Investigator of the STAMPEDE study; an amazing ongoing series of practice-changing randomised trials for men with advanced prostate cancer. Nick discusses recent highlights of STAMPEDE, imminent developments in STAMPEDE, the impact of PSMA PET/CT, as well as some challenges in the COVID era. He also discusses his recent move from Birmingham to the Institute of Cancer Research/Royal Marsden, and his son's recent Zoom wedding in South America! Regular hosts Declan Murphy and Renu Eapen are joined in studio by Associate Professor Arun Azad, medical oncologist at Peter MacCallum Cancer Centre.