Statin Myopathy

Guest: Stephen Kopecky, M.D.

Host: Sharonne Hayes, M.D.

Statins are very helpful to lower LDL cholesterol and subsequently lower cardiovascular risk.  Studies of statins have excluded subjects that are statin intolerant which is usually due to muscle symptoms such as aches, called myalgias, muscle cramps, or weakness.  One of the most significant predictors of statin intolerance is the dose -the higher the dose, the more likely to develop intolerance.  Accepted in recommended ways to minimize intolerance is to use generic combination therapy with a lower dose statin and a cholesterol absorption inhibiting agent such as ezetimibe.  Newer agents such as PCS K 9 inhibitors and inclisiran, both given subQ, and bempedoic acid may reduce statin muscle symptoms.

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Podcast episode transcript found here.