In this week's episode, Joe Ross, professor of medicine at Yale, and The BMJ's US research editor, and Juan Franco, researcher at Heinrich-Heine-Universität and editor in chief of BMJ EBM are in the hot-seat.

They will discuss new research on the effectiveness of antidepressants - based on all the individual patient data submitted to the FDA between 1979 and now.

We'll take a look at a study of industry sponsorship of cost effectiveness analysis, and seeing similar patters of publication bias to RCTs.

And finally we'll be talking about new research on the ongoing, and emergent pandemics - covid and monkeypox.

Reading listResponse to acute monotherapy for major depressive disorder in randomized, placebo controlled trials submitted to the US Food and Drug Administration: individual participant data analysis

https://www.bmj.com/content/378/bmj-2021-067606)

Using individual participant data to improve network meta-analysis projects

https://ebm.bmj.com/content/early/2022/08/10/bmjebm-2022-111931

Industry sponsorship bias in cost effectiveness analysis: registry based analysis

https://www.bmj.com/content/377/bmj-2021-069573

Clinical features and novel presentations of human monkeypox in a central London centre during the 2022 outbreak https://www.bmj.com/content/378/bmj-2022-072410

Effectiveness of a fourth dose of covid-19 mRNA vaccine against the omicron variant among long term care residents in Ontario, Canada: