Was your psoriasis caused by the Black Death? Learn more than you might have wanted to know about the Black Death and delve into the data on the immunologic/autoimmune ramifications of wiping out nearly half of Europe.

·       Intro 0:11

·       In this episode 1:09

·       The Black Death 1:24

·       The History of IV Immunoglobulin episode 2:07

·       How the Black Death happened 4:07

·       How many people died from the Black Death? 6:49

·       Record keeping 6:53

·       The modern immune system, the Black Death and HIV 8:43

·       What is CCR5? 8:55

·       Current data on autoimmune diseases 10:35

·       ERAP2 15:55

·       How yersinia pestis kills you 21:04

·       The inflammasome 22:03

·       The Inflammasome for Dunces episode 22:09

·       Mediterranean fever and mouse model 24:49

·       Takeaways 30:20

·       Summary 30:59

Disclosures: Brown reports no relevant financial disclosures.

We’d love to hear from you! Send your comments/questions to Dr. Brown at [email protected]. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum.

References:

Wheelis M. Emerg Infect Dis. 2002;doi:10.3201/eid0809.100536.

Ratner D, et al. PLoS Pathog. 2016;doi:10.1371/journal.ppat.1006035.

Park YH, et al. Nat Immunol. 2020;doi:10.1038/s41590-020-0705-6.

Patin E. Nat Immunol. 2020;doi:10.1038/s41590-020-0724-3.

Galvani AP, et al. Proc Natl Acad Sci USA. 2003;doi:10.1073/pnas.2435085100.