Was your psoriasis caused by the Black Death? Learn more than you might have wanted to know about the Black Death and delve into the data on the immunologic/autoimmune ramifications of wiping out nearly half of Europe.

· Intro 0:11

· In this episode 1:09

· The Black Death 1:24

· The History of IV Immunoglobulin episode 2:07

· How the Black Death happened 4:07

· How many people died from the Black Death? 6:49

· Record keeping 6:53

· The modern immune system, the Black Death and HIV 8:43

· What is CCR5? 8:55

· Current data on autoimmune diseases 10:35

· ERAP2 15:55

· How yersinia pestis kills you 21:04

· The inflammasome 22:03

· The Inflammasome for Dunces episode 22:09

· Mediterranean fever and mouse model 24:49

· Takeaways 30:20

· Summary 30:59

Disclosures: Brown reports no relevant financial disclosures.

We'd love to hear from you! Send your comments/questions to Dr. Brown at [email protected]. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum.

References:

Wheelis M. Emerg Infect Dis. 2002;doi:10.3201/eid0809.100536.

Ratner D, et al. PLoS Pathog. 2016;doi:10.1371/journal.ppat.1006035.

Park YH, et al. Nat Immunol. 2020;doi:10.1038/s41590-020-0705-6.

Patin E. Nat Immunol. 2020;doi:10.1038/s41590-020-0724-3.

Galvani AP, et al. Proc Natl Acad Sci USA. 2003;doi:10.1073/pnas.2435085100.