The Future of Everything

By Stanford EngineeringScience Medicine Health & Fitness Technology

The Future of Everything episodes

July 19, 2019 Sylvia Plevritis: Better cancer treatment through data
Biomedical data scientist Sylvia Plevritis is an expert in computational modeling of cancer risk and treatment options hidden in the remarkable quantity of data available today. Rarely is a tumor made up of a single mutation, she says, but more commonly of a mix of different mutations. Such heterogenous tumors may require complex combinations of drugs to produce the most effective treatments. That’s where computers can help.
Using mathematical simulations, Plevritis is helping patients and their doctors understand the genetic makeup of a given cancer for the purpose of identifying drug combinations that stand a better chance of success. Some of the models Plevritis works with can be run in an hour or less and yet return invaluable guidance that can save a patient’s life.
Plevritis says these computational approaches can even help those without cancer understand their inherent genetic risks to assess whether and when additional screening or risk-reducing interventions are warranted.
Join host Russ Altman and biomedical data scientist Sylvia Plevritis as they dive into the promising intersection of computers and cancer care. You can listen to The Future of Everything on Sirius XM Insight Channel 121, iTunes, Google Play, SoundCloud, Spotify, Stitcher or via Stanford Engineering Magazine.
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28 min
July 19, 2019 James Landay: What’s next in human-computer interaction?
Computers are everywhere and humans are engaging with them in nearly everything they do. Knowing this, the question becomes: How do we design a world around us so that technology makes life better, not worse? James Landay, an expert in human-computer interaction, says the key to thoughtfully integrating humans with digital technology is to put people first.
This perspective draws on a philosophy known as human-centered or user-centered design. Within this approach, the first priority is to understand the problem vexing a particular population by observing, interviewing, and working with that population. Only once the problem is clear does the development of a solution begin. Typically, engineers and technologists have done the opposite. They’ve worked to develop the coolest technology they can think of, and then once it’s ready look around for a way to use it.
With human needs at the forefront, Landay’s research focuses on finding ways to use artificial intelligence technology to augment human performance. His current projects range from leveraging technology to encourage positive behavior change, to enabling kids to stay engaged in their education, to helping professionals stay healthy while feeling more connected to their co-workers and workplace.
Tune in to this episode of The Future of Everything to hear more about how Landay draws on user-centered design to develop technology that supports human needs. You can listen to The Future of Everything on Sirius XM Insight Channel 121, iTunes, Google Play, SoundCloud, Spotify, Stitcher or via Stanford Engineering Magazine.
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28 min
July 12, 2019 Jeremy Weinstein: Technology in the public interest
Political scientist Jeremy Weinstein has worked at both the White House and the United Nations. In both jobs, he encountered the ethical and policy concerns that new technologies can present to policymakers. As one example, he points to the fierce debate between Apple and national security experts over end-to-end encryption and the challenges investigators faced in accessing data on the iPhones of the perpetrators of a terrorist attack in San Bernardino in 2015.
He wants universities, like Stanford, to educate a new breed of engineer that he refers to as a “civic-minded technologist.” These engineers would consider ways in which technological advances could serve the public good, while also thinking critically about the impacts of new technologies on society.
In this spirit, Weinstein and two Stanford colleagues, Rob Reich and Mehran Sahami, have begun teaching a new course on the ethics and policy of technology to a large number of undergraduate CS majors. He says it’s critical that these nascent technologists learn from the start to think about the larger implications of their work – even before they write a single line of code. This is because code itself is not value neutral, and technologists must be able to recognize what values are being encoded in the programs they write as well as the competing values that might be traded off. This kind of preparation, he says, will help us as a society to more effectively realize the benefits and minimize the potential harms inherent in new technologies.
In his own research, Weinstein is applying his unique perspective to challenges of global poverty and human migration, where, he says, advances in artificial intelligence and machine learning are changing our understanding of two of society’s fundamental problems.
Join host Russ Altman and political scientist Jeremy Weinstein for an in-depth look at the ethical and political implications of technology. You can listen to The Future of Everything on Sirius XM Insight Channel 121, iTunes, Google Play, SoundCloud, Spotify, Stitcher or via Stanford Engineering Magazine.
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29 min
June 28, 2019 Kari Nadeau: Science takes on food allergies
Once avoidance was the only answer, but a leading allergist says that advances in desensitizing allergies are challenging common convention.
Food allergy expert Kari Nadeau, MD, PhD, says that as many as one in ten adults in the U.S. has a food allergy, many without knowing it. With consequences that range from mild to serious (including lethal anaphylaxis), it is imperative that medical scientists become better adept at spotting food allergies and ultimately at helping patients cope with allergies.
Nadeau notes that while a cure remains elusive, it’s a "moonshot issue" worthy of pursuit. She has seen positive results with incremental desensitization therapies that build a patient's tolerance for foods that cause allergic reactions. In addition, new gene therapies are just emerging that are offering a glimmer of promise for those whose diets and lifestyles have been impacted by food allergies.
Join host Russ Altman — once allergic to seafood but now able to indulge in lobster thanks to desensitization therapy — and allergist Kari Nadeau for a look ahead at the hopeful future for people with severe food allergies. You can listen to The Future of Everything on Sirius XM Insight Channel 121, iTunes, Google Play, SoundCloud, Spotify, Stitcher or via Stanford Engineering Magazine. Connect With Us:
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29 min
June 04, 2019 Monica Lam: Privacy in the age of virtual assistants
Can we reap the benefits of artificial intelligence while also protecting our personal information?
From scheduling appointments to setting the thermostat to ordering pizza, virtual assistants are growing more commonplace by the day. Stanford professor Monica Lam says they will only become more entrenched as their capabilities grow and their voice-recognition skills become more accurate.
Such developments are welcomed by many who rely upon Alexa and Siri and other virtual assistants. But it is also troubling to those, like Lam, who worry that privacy concerns and lack of competition put too much power in the hands of a few companies. Lam is an advocate for a more open approach.
“If there is no open competition, then you are kind of stuck with whatever these platforms provide for you,” she tells host Russ Altman in the latest episode of The Future of Everything radio show from Sirius XM.
Lam thinks a lot about the future of privacy. She says we can have both the AI and privacy at the same time, but first she’d like more options in the marketplace and for those who dominate the market to be less insular than they are today. What’s needed is an “infrastructure of privacy” that returns control of data to the rightful owners: the users who created it in the first place. The key to that, she says, is choice.
Tune in to this episode of The Future of Everything to hear more about how Lam’s open-source effort to develop and share virtual assistant technology is keeping user privacy at the forefront. You can listen to The Future of Everything on iTunes, Google Podcasts, SoundCloud, Spotify, Stitcher or via Stanford Engineering Magazine.
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29 min
May 31, 2019 Sharad Goel: How hidden bias affects the criminal justice system
In-depth statistical analyses show time and again that subtle, unconscious bias is pervasive in the American justice system. The bigger question, however, is what to do about it?
Sharad Goel is an expert in computational social science – that is, using computers and data to examine and address policy issues. He says unconscious bias is subtle but entrenched in American life, and nowhere are the consequences more concerning than in criminal justice.
Goel has analyzed hundreds of millions of crime records to show, for instance, that black drivers are pulled over more than white drivers and that judges demand bail too often. He says the data suggest that up to 30 percent more people could be released on their own recognizance without adversely affecting crime rates.
Goel is developing risk assessment tools to assist in high-stakes decision making. He cautions, however, that algorithms are an aid, not a panacea. They should be used to inform decision making and to help decision makers to make fairer choices, but not to actually make the decisions.
Listen in as host Russ Altman and expert in social data science Sharad Goel discuss bias and transparency in the criminal justice system. You can listen to The Future of Everything on iTunes, Google Podcasts, SoundCloud, Spotify, Stitcher or via Stanford Engineering Magazine. Connect With Us:
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29 min
May 06, 2019 Paul Yock: Innovation in medical technology
When Stanford’s Paul Yock was a young interventional cardiologist, he was frustrated by the complex, two-person process required to deliver life-saving stents. So, he invented a better way. His Rapid Exchange stenting and balloon angioplasty system, one of several inventions Yock is known for internationally, can be managed by just a single operator, making procedures like stent placement faster and safer. Yock is a man of many talents. He is a doctor, a professor of bioengineering and of mechanical engineering, and an innovator who combines these many interests to solve problems in healthcare.
He says that the aha moments work beautifully when they come, but they are too often based in luck. For the rest of us, there is a better and more consistent path to transformative medical tools he calls the biodesign process. It starts, first, with a deep understanding of the medical need. The next step is brainstorming and iteration, preferably by non-hierarchical, multidisciplinary teams of doctors, engineers and business people. Diversity of insights and expertise leads to better inventions, Yock says.
Join host Russ Altman and physician-inventor Paul Yock for an exploration of innovation as a process that can be learned and repeated. You can listen to the Future of Everything on Sirius XM Insight Channel 121, iTunes, SoundCloud and Stanford Engineering Magazine.
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29 min
May 06, 2019 Margaret Brandeau: Math and computers help reshape health policy
Margaret Brandeau may carry a business card that reads Professor of Management Science and Engineering, but her expertise is in using complex systems models to solve challenges in public health policy. For instance, she recently created a sophisticated computer model of the national opioid crisis, which led her to the stark –and surprising – conclusion that it may take a short-term rise in deaths to ultimately reduce them.
She didn’t come to that conclusion lightly, but made no less than 10 models of drug-user behaviors to analyze interventions. Nonetheless, each model led her to the same basic conclusions. First, policies are needed that lead to cutbacks in the number of prescriptions of opioids for pain management. Second, fewer prescriptions of opioids for pain management will cause some individuals to turn to more-deadly heroin. Third, because of this unintended consequence, it is essential to also scale up treatment for opioid-addicted individuals. But her fourth finding was the most sobering of all: No one of these policies will suffice; they must all be combined if we are to curb the opioid epidemic – and the epidemic is not likely to abate significantly anytime soon.
Mathematical modeling is an art, Brandeau says, but it’s a powerful art that is only going to grow in influence. Her advice for those looking to solve big problems – from reducing sodium intake to battling the return of measles – is to start out simple. Know what question you want to answer and create a model that captures just the most salient elements of the problem. Things will flow from there.
Join host Russ Altman and mathematical modeling expert Margaret Brandeau for a deep look at the many ways algorithms are changing our understanding of and approaches to the challenges of public health. You can listen to the Future of Everything on Sirius XM Insight Channel 121, iTunes, SoundCloud and Stanford Engineering Magazine.
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28 min
April 22, 2019 Tony Oro: Stem cell therapies for incurable diseases
By last count, there are 5,000 genetic diseases in the human body.
A few are merely annoying, but far more are devastating and without cure. In the last decade, much popular attention has been focused on the potential for stem cells and gene therapies to cure these once-intractable diseases. While the promise is clear, Tony Oro cautions patience.
Oro is a dermatologist and associate director of the Center for Definitive and Curative Medicine at Stanford. He is a leading expert in the scientific and ethical dilemmas such therapies raise. He and many others say cures are close at hand, but there is still much to be determined before these therapies can be pronounced both effective and safe.
Join host Russ Altman and medical ethicist Tony Oro for an inspiring but cautionary look at the promise of stem cell and gene therapies. You can listen to the Future of Everything on Sirius XM Insight Channel 121, iTunes, SoundCloud and Stanford Engineering Magazine.
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30 min
April 22, 2019 Michelle Monje: New therapies for brain cancer
Brain cancers are known to be elusive and clever killers, but Michelle Monje, associate professor of neurology and neurological sciences, is helping to find new treatments through a better understanding of how healthy brain cells develop and how cancers often hijack those very same processes in order to grow themselves.
Monje says that the last decade has seen tremendous progress in our understanding of how cancers thrive and in the development of new drugs and therapies to kill the killers. Unfortunately, many chemotherapy drugs powerful enough to kill cancers also cause lasting impairment of the patient’s cognitive abilities, a condition known among doctors and patients as “chemobrain.”
Monje is on the hunt for more effective and safer treatments for brain cancer. One exciting development, she says, is a quickly evolving field known as immunotherapy, which harnesses the body’s own immune system to recognize and to kill cancers. She’s also exploring a new drug that can help specific brain cells, known as glia, counteract the harmful effects of chemobrain.
Join host Russ Altman and brain cancer expert Michelle Monje for an inspiring look at new and safer treatments for brain cancer. You can listen to the Future of Everything on Sirius XM Insight Channel 121, iTunes, SoundCloud and Stanford Engineering Magazine.
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28 min

About The Future of Everything

From the publisher's feed

Host Russ Altman, a professor of bioengineering, genetics, and medicine at Stanford, is your guide to the latest science and engineering breakthroughs. Join Russ and his guests as they explore cutting-edge advances that are shaping the future of everything from AI to health and renewable energy.