The Future of Everything

The current process for diagnosing autism requires no less than 10 hours of intensive doctor-to-patient observation.

It is expensive and time-consuming, says autism expert Dennis Wall, an associate professor of pediatrics and of biomedical data science at Stanford. Wall is developing new ways to tackle the problem.

He says advances in machine learning, a branch of artificial intelligence focused on training computers to perform important medical tasks, stand to shake up the field. He’s developing computer models that can spot autism by watching just a few minutes of video of a child at play in their natural home environment.

With these technologies, diagnosis happens in as little as four minutes. In addition, Wall says, scoring can be done by non-experts, rather than highly trained psychiatrists, lowering the costs further. He thinks such AI models could reduce bottlenecks and get kids with autism into treatment sooner, a key to maximizing the treatment’s effect.

Beyond diagnosis, Wall says that digital technologies together with AI are also changing therapeutics. For example, he’s developing augmented reality applications, one for Google Glass, that can help autistic kids better recognize and learn emotional cues – anger, joy, sadness – in the faces of others, a particular challenge for those with autism. Another that goes beyond the wearable form factor to even more ubiquitous technologies – your phone – is an app that can teach social skills through fun but poignant AI-enabled games, such as charades, where imitation advances the child’s social skills as the AI engine tracks progress automatically.

Join host Russ Altman and autism expert Dennis Wall for a peek into the rapidly changing world of autism diagnosis and treatment. You can listen to the Future of Everything on Sirius XM Insight Channel 121, iTunes, SoundCloud and Stanford Engineering Magazine.

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Mechanical engineer Xiaolin Zheng really likes to burn things, but she is more like a modern-day Prometheus than a pyromaniac. She uses combustion to create minute nanoparticles of various metal oxides that have many practical and valuable uses in today’s world.

For instance, she has created nanoparticles that can turn water into hydrogen peroxide using only energy from the sun. Hydrogen peroxide is a powerful disinfectant that kills microbes and removes other pollutants from water. Zheng imagines creating inexpensive, portable, solar-powered water purifiers to help the two to three billion people in the world who lack access to plentiful potable water.

Join host Russ Altman and Xiaolin Zheng for a fascinating look at the benefits of combustion. You can listen to the Future of Everything on Sirius XM Insight Channel 121, iTunes, SoundCloud and Stanford Engineering Magazine.

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In safety engineering, ergonomic differences between men and women are important. Conventional seat belts do not fit pregnant women properly and motor vehicle crashes are the leading cause of fetal death related to maternal trauma. Analyses of sex differences have led to the development of pregnant crash test dummies that enhance safety in automobile testing and design.

In medicine, osteoporosis has been conceptualized primarily as a women's disease, yet after a certain age men account for nearly a third of osteoporosis-related hip fractures. Tragically, when men break their hips, they tend to die. We don't know why. Analyzing the interaction between sex and gender in osteoporosis has led to new diagnostics for men, and the search for better treatments is underway.

In these and many other cases, historian Londa Schiebinger points out that if we don't consider sex or gender analysis, past bias may be perpetuated into the future, even when governments, universities and companies have implemented policies to foster equality.

The big question now, she says, is: How can humans automate processes that also contribute to creating a fair and equal society? Schiebinger highlights examples of efforts where computer scientists are working to create mathematically rigorous definitions of fairness in order to develop and optimize algorithms that guarantee fairness. There is much work to be done, but as Scheibinger sees it, there is a big opportunity for these algorithms as well as the robotic systems they will enable to challenge and eventually reconfigure gender norms.

Join host Russ Altman and historian of science Londa Schiebinger for a closer look at how to employ methods of sex and gender analysis as a resource to create new knowledge and stimulate novel design. You can listen to the Future of Everything on Sirius XM Insight Channel 121, iTunes, SoundCloud and Stanford Engineering Magazine.

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Stanford radiation oncologist, Billy Loo, says that a new generation of radiation therapy technology called PHASER will be so fast that it can even compensate for the patient moving during treatment.

High-energy X-rays will be fired so quickly, like a flash photograph, that motion is frozen and radiation can be more precisely focused on tumors. His research team is also finding that such ultra-fast “FLASH” radiation kills cancer cells through new biological mechanisms while causing less damage to healthy tissues.

Loo says that while radiation benefits two-thirds of U.S. patients, half of patients with cancer around the world lack access to these curative technologies. To address issues of access, the Stanford Radiation Oncology and SLAC National Accelerator Laboratory team is designing PHASER to be a mobile unit that will fit in a standard cargo shipping container and can be powered by solar energy.

Join host Russ Altman and radiation oncologist Billy Loo for a discussion of advances in radiation therapy that are giving new optimism to cancer patients and others. You can listen to the Future of Everything on Sirius XM Insight Channel 121, iTunes, SoundCloud and Stanford Engineering Magazine.

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Carlos Bustamante is an expert in genomics—the study of genetic variation and its effects on the living world. He says genomics holds tremendous promise but, so far, virtually all sequenced DNA comes from European blood lines and this presents a problem.

Without greater diversity in the genomic data that is collected, he notes that we cannot fully reap the benefits of this knowledge, particularly in areas such as healthcare.

"Genomics is the new oil," Bustamante says, of the opportunities that lie ahead. It's being used for everything from studying rare diseases to developing more effective drugs. Before its potential can be fully realized,however, genomics will have to address its diversity problem. The more genetic variants that are represented in the genomic data collected, the better equipped we'll be to understand and improve human health.

Join host Russ Altman and geneticist Carlos Bustamante for a peek into the wonders of genomics.

You can listen to the Future of Everything on Sirius XM Insight Channel 121, iTunes, SoundCloud and Stanford Engineering Magazine.

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Why do well-off public schools often demand that parents supplement school programs with personal contributions? Why do many rare diseases receive the lion’s share of donor attention and money? Is basic science being driven by the whims of big donors?

These are questions that keep Stanford political philosopher Rob Reich up at night. Reich says that philanthropy is at an ethical crossroads in which the heart often leads the head in determining which causes get showered with money while other, perhaps more deserving, ones go without.

Join host Russ Altman and Rob Reich for a look at the promise and peril of philanthropy and what can be done to make it serve rather than subvert democracy.

You can listen to the Future of Everything on Sirius XM Insight Channel 121, iTunes, SoundCloud and Stanford Engineering Magazine.

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Of the many nations that have implemented some measure of digital democracy, none perhaps has had more success than Estonia. Toomas Ilves, a Distinguished Visiting Fellow at the Hoover Institution, would know: He served as president of the Baltic state for two terms. Ilves says that all Estonians have verifiable digital identities and they use them to vote, sign legal documents, order prescription medication, file taxes and more online.

Estonian digitization began with schools and banking in the 1990s. Online voting followed in the early 2000s. Today, a third of Estonians vote online. Faith in the system is high, Ilves says. The country has a single voter registry and voters can confirm – and even change – their votes right up to the deadline. Estonia’s latest effort is a comprehensive genome project that will fuel a new era of personalized medicine.

Join host Russ Altman and former Estonian President Toomas Ilves for a broad conversation about the challenges and the promise of digital democracy.

You can listen to the Future of Everything on Sirius XM Insight Channel 121, iTunes, SoundCloud and Stanford Engineering Magazine.

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In hospitals across the world, the unmet need for end-of-life palliative care threatens to overwhelm the few doctors who are equipped to adequately provide counseling that can help patients die on their own terms. There are just too many patients and too few doctors.

Stanford’s Nigam Shah, an expert in medical informatics, says that such scenarios may soon become a thing of the past. Artificial intelligence, founded on tens-of-thousands of data points gathered from millions of patients, is flipping such age-old scripts to change how and with whom care conversations happen. It is but one example of the many ways AI is reshaping medicine, but these major advances are not without ethical concerns, Shah says.

Join host Russ Altman and Nigam Shah for in-depth look at the growing influence of “data-driven medicine.”

You can listen to the Future of Everything on Sirius XM Insight Channel 121, iTunes, SoundCloud and Stanford Engineering Magazine.

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The worlds of academic economics and ride sharing are not so far removed – just ask Stanford labor economist Paul Oyer. When Oyer wanted to study the gig economy, he didn’t do it from afar; he became an Uber driver.

Oyer says lessons from the gig economy hold deep lessons for the job market for more traditional jobs. Uber’s surge pricing, for instance, is more than a payment structure – it entices Uber drivers to work odd hours or at times of peak demand. He says Uber is constantly reworking its payment structure to ensure that the company and its drivers’ interests are aligned to reduce workforce turnover.

You can listen to the Future of Everything on Sirius XM Insight Channel 121, iTunes, SoundCloud and Stanford Engineering Magazine.

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It’s nothing we haven’t already heard – the news you read is being shaped by the ubiquitous presence of social media. So-called “fake news” spread by bots and social media may continue to influence American elections and, ultimately, democracy.

Alex Stamos, the former chief security officer at Facebook and an adjunct professor with Stanford’s Freeman Spogli Institute for International Studies, explained at a recent live taping of “The Future of Everything” that the emergence of social media has made everyone a potential publisher. “We will never go back to the era in which a small number of people control the flow of information,” Stamos says.

While social media can be credited with democratizing the dissemination of information, these platforms have also become a hotbed of false and misleading content spread by domestic and foreign actors. Solving the “fake news” problem is extremely difficult, Stamos explains. “It turns out that regulating social media actually means asking social media companies to regulate people’s freedom of speech.” The danger here, Stamos emphasizes, is that this regulation will be done in a way that benefits the short-term interests of a company and does not uphold basic human rights.

You can listen to the Future of Everything on Sirius XM Insight Channel 121, iTunes, SoundCloud and Stanford Engineering Magazine.

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