Psychiatrist Richard A. Friedman explains how a rare genetic mutation affecting the enzyme FAAH, and a ubiquitous neurotransmitter called Anandamide may account for unusually low anxiety, reduced drug cravings, and an innate buoyancy, the type of which you might find in a daily podcast host. Plus,  Louisville reverses its immigration detainer policy under federal pressure, reigniting the debate over sanctuary cities and local autonomy. And in the Spiel a burial standoff concerning the former President of Zambia.

Produced by Corey Wara

Production Coordinator Ashley Khan

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Historian Daniel Immerwahr eviscerates RFK Jr. as a master of glib misinformation—“profoundly informed,” yet wielding that knowledge in bad faith to undermine truth and public trust. Kennedy is the conductor of an orchestra of error. Also discussed: how science became political dogma during COVID, how Fauci’s certainty helped fuel backlash, and why a provocateur like Kennedy thrives in epistemological gray zones. Also on the show: Trump’s obscure-commission chess moves, as he "Truths" his way through any Epstein flak. Produced by Corey Wara Production Coordinator Ashley Khan Email us at ⁠⁠⁠⁠[email protected]⁠⁠⁠⁠ To advertise on the show, contact ⁠⁠⁠⁠[email protected]⁠⁠⁠⁠ or visit ⁠⁠⁠⁠https://advertising.libsyn.com/TheGist⁠⁠⁠⁠ Subscribe to The Gist: ⁠⁠⁠⁠https://subscribe.mikepesca.com/⁠⁠⁠⁠ Subscribe to The Gist Youtube Page: ⁠⁠⁠⁠https://www.youtube.com/channel/UC4_bh0wHgk2YfpKf4rg40_g⁠⁠⁠⁠ Subscribe to The Gist Instagram Page: ⁠⁠⁠⁠GIST INSTAGRAM⁠⁠⁠⁠ Follow The Gist List at: ⁠⁠⁠⁠Pesca⁠⁠⁠⁠ ⁠⁠⁠⁠Profundities | Mike Pesca | Substack⁠⁠⁠⁠

On this Saturday we play some of Mikes conversation on the podcast Live From America Hatem Gabr, one of the cohosts talks to Mike about NPR and the media landscape. Produced by Corey Wara Production Coordinator Ashley Khan Email us at ⁠⁠⁠⁠[email protected]⁠⁠⁠⁠ To advertise on the show, contact ⁠⁠⁠⁠[email protected]⁠⁠⁠⁠ or visit ⁠⁠⁠⁠https://advertising.libsyn.com/TheGist⁠⁠⁠⁠ Subscribe to The Gist: ⁠⁠⁠⁠https://subscribe.mikepesca.com/⁠⁠⁠⁠ Subscribe to The Gist Youtube Page: ⁠⁠⁠⁠https://www.youtube.com/channel/UC4_bh0wHgk2YfpKf4rg40_g⁠⁠⁠⁠ Subscribe to The Gist Instagram Page: ⁠⁠⁠⁠GIST INSTAGRAM⁠⁠⁠⁠ Follow The Gist List at: ⁠⁠⁠⁠Pesca⁠⁠⁠⁠ ⁠⁠⁠⁠Profundities | Mike Pesca | Substack⁠⁠⁠⁠ 

The self-proclaimed “Trash Daddy” riffs on meat-in-a-can cuisine, possum PR, and how his accent disarms blue-state crowds, Plus: white supremacist losers, Fruit Loop vape rights, and how cheap heat works in comedy and pro wrestling. Trae takes us through his upbringing, in Celina Tennessee, and discusses his travails with child support bureaucracy , plus he discusses his interpersonal interactions with JD Vance who hit big about the same time Trae did. The two became friendly.  For a while. Produced by Corey Wara

Production Coordinator Ashley Khan

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Jake Tapper returns to dissect his book Original Sin and the failures of mainstream media to report on Joe Biden’s decline.  He traces how social pressures, cultural taboos, and partisan incentive structures are ongoing threats to the type of journalism he practices and associates with the best forms of truth-telling. Tapper says CNN still strives to flesh out the full story, but acknowledges the shrinking market for non-ideological reporting. Plus, a glimpse into the spectacle of immigration enforcement, where shocking imagery is a Presidential tactic and a public turnoff.

Produced by Corey Wara

Production Coordinator Ashley Khan

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Sadie Dingfelder returns to assess the national stomp-fest against lantern flies and asks: did it do anything, or was it all buggage and bluster? Then, a deep dive into the Supreme Court’s CASA ruling on nationwide injunctions, and how a seemingly dramatic limitation on judicial power proved to be less than world-shifting in practice. Finally, Trump disavows Epstein file disclosure demands, setting off a civil war within MAGA media as conspiratorial cracks widen and cranks rage. Produced by Corey Wara

Production Coordinator Ashley Khan

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Times of Israel analyst Haviv Rettig Gur discusses the next phase of the war in Gaza and Israel's many enemies. Also discussed are the ideological roots of Hamas’s mission to destroy Israel, settler violence in the West Bank, and the difficulty of safely getting food to the citizens of Gaza. Produced by Corey Wara

Production Coordinator Ashley Khan

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Murderbot showrunners Chris and Paul Weitz join to discuss their sci-fi series’ blend of chamber thriller, workplace satire, and reluctant hero tale—all orbiting a security unit who just wants to be left alone to binge it's stories. They talk robot servitude, world-building exhaustion (“every chair must be a space chair”), and how Alexander Skarsgård’s performance brings Scandinavian placidity to a roiling interior monologue. Also: the GOP goes ball(point)istic over Biden’s legal use of an autopen.

Produced by Corey Wara

Production Coordinator Ashley Khan

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The TSA is finally starting to phase out its decades-old shoe removal policy. We take a look back at the post-9/11 panic that made bare feet in airport security lines a national ritual—and wonder how we went from hypervigilant to oddly indifferent about terrorism. Plus, from the vaults: A classic Spiel from July 17, 2017, revisits Ann Coulter vs. Delta, Day 3. Yes, it somehow made it to Day 3. Produced by Corey Wara

Production Coordinator Ashley Khan

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Tony Tost, now showrunning Poker Face, reflects on the show's expertly woven mysteries, genre roots, and why women who don’t want to pick up a gun keep finding themselves forced to fire. Tost, an expert in poetry and Johnny Cash, brings a reverence for populist storytelling to a format that straddles the procedural and the mythic. He also discusses why westerns are still a hard sell in Hollywood—even when they’re smart, stylish, and starring Sydney Sweeney. Plus, Mike gets hit with a burst of esprit de l’escalier over NATO dues and Plymouth Barracudas.

Produced by Corey Wara

Production Coordinator Ashley Khan

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