New York comic Janelle James never even imagined being a comedian. She had grown up in the Virgin Islands, worked in fashion PR, had two kids, and was living in Illinois when she first walked on stage at an open mic night. She was 30 years old. But as soon as she hit the stage, she knew this was her calling and many years later she's headlining clubs all over the country and is a comedy star on the rise. She talks about trying to outrun her depression, dealing with depression-induced physical pain, and a therapy session that did not work out. Special guest: neuroscientist Daniel Levitin.

New York comic Janelle James never even imagined being a comedian. She had grown up in the Virgin Islands, worked in fashion PR, had two kids, and was living in Illinois when she first walked on stage at an open mic night. She was 30 years old. But as soon as she hit the stage, she knew this was her calling and many years later she's headlining clubs all over the country and is a comedy star on the rise. She talks about trying to outrun her depression, dealing with depression-induced physical pain, and a therapy session that did not work out. Special guest: neuroscientist Daniel Levitin.

She's the author of bestselling books and an incredibly popular blog, but Jenny Lawson showed up to our interview wondering, at least a little, if her appearance on this show and her whole career, really, was part of some delusion. It's not. She's the real thing: an incredibly funny and honest writer with a legion of fans, a very old decapitated and stuffed boar's head named James Garfield, anxiety, depression, and a clear-eyed view of the world.

We’ve gathered up a whole lot of tips, tricks, ideas, and stories to help you get through this time of year when merriness and jolliness aren’t always in abundant supply. Hear holiday thoughts from Wil Wheaton, Margaret Cho, Jenny Lawson, John Green, Aimee Mann, and more. Plus, a story about a slobbering zebra.

You know those things that happened but that you don't talk about very much? Or even at all? Because they're too upsetting? In this episode, host John Moe and guest Ana Marie Cox put those things on the table. Ana is a journalist, pundit, and podcaster; she talks about the lowest point in her mental health, a horrible decision, and what came next. John talks about the event that led to this podcast being created in the first place. This is a re-broadcast of an episode from last spring that has garnered a huge response from listeners, and it's presented largely without edits.

Growing up, actor and writer Julie Klausner was too busy battling depression and daydreaming about an imagined Merlot-sipping cosmopolitan adulthood to really engage in the world itself. It wasn’t until she entered the world of comedy and improv as an adult that things really started to click into place. That led to creating Difficult People, a show on Hulu, where she plays a much bolder, brassier, and more oblivious version of herself.

Growing up, actor and writer Julie Klausner was too busy battling depression and daydreaming about an imagined Merlot-sipping cosmopolitan adulthood to really engage in the world itself. It wasn’t until she entered the world of comedy and improv as an adult that things really started to click into place. That led to creating Difficult People, a show on Hulu, where she plays a much bolder, brassier, and more oblivious version of herself.

Long before Jeff Tweedy was the founder and leader of the enormously popular band Wilco, he was a kid in Illinois with severe migraines and a tendency toward anxiety and depression. He cycled through alcohol, marijuana, and, finally, opioids to try to get to the point of feeling normal and okay, even relying on a fan who worked at Walgreen’s to score him the pills he wanted. Finally, a stint in rehab and a return of self-confidence got him back on track. There’s a really sad and darkly funny story in this episode involving a teddy bear and a jar.