A quick take on one of the little-appreciated engines of the innate immune system.

• Intro :10
• A little about this episode :25
• The inflammasome is a component of the innate immune system 3:12
• Remember NLRP3 4:12
• The toll-like receptors 5:05
• Triggering the inflammasome 7:05
• The proteins 8:04
• A medieval battle and a trebuchet 9:56
• A disclosure 17:00
• I hope you enjoyed this episode 18:06

We'd love to hear from you! Send your comments/questions to [email protected]. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum

References:

Booshehri LM, Hoffman HM. J Clin Immunol. 2019;39:277-286.

Hasudungan A. Immunology – NOD like receptors and the inflammasome [Video]. YouTube. https://www.youtube.com/watch?v=biunM2iD8qM&t=4s. Published March 29, 2015. Accessed September 4, 2019.