People with Down syndrome face a high risk of developing Alzheimer’s disease, which is the leading cause of death in this population over the age of 35.

In this episode, Morgane Boillot (Senior Editor) is joined by Professor Michael Rafii to explore the intersection of Down syndrome and Alzheimer’s disease. They discuss the latest research into disease pathology, biomarkers, and clinical trials, and examine the key challenges and future opportunities in understanding and treating Alzheimer’s disease in individuals with Down syndrome.

Read the Rapid Review:

https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(25)00237-6/fulltext?dgcid=buzzsprout_icw_podcast_August_25_laneur

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In this episode, host Laura Hart chats with Professor Amit Bar-Or (University of Pennsylvania) about the potential of the BTK inhibitor fenebrutinib in treating relapsing multiple sclerosis, highlighting future challenges in MS research.

Read the full article:

https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(25)00174-7/fulltext?dgcid=buzzsprout_icw_podcast_July_25_laneur

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Sarah Passey is joined by Dr Marte-Helene Bjørk (Haukeland University Hospital, Norway) to discuss the latest evidence and practical guidance on managing reproductive risks in people with epilepsy, including medication safety, pregnancy planning, and global challenges in care.

Read the full article:

https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(25)00130-9/fulltext?dgcid=buzzsprout_icw_podcast_June_25_laneur

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Assistant Editor Sam Griffiths is joined by Professor Geoff Manley (UCSF, CA, USA) to discuss his new NIH-NINDS classification of acute TBI, the limitations of traditional classifications, how the new framework was developed, and what it means for the future of TBI research and patient care.

Read the full article:

https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(25)00154-1/fulltext?dgcid=buzzsprout_icw_podcast_May_25_laneur

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Increasing numbers of people are surviving stroke but with motor impairments that can contribute substantially to long-term disability. 

Transcranial direct current stimulation has shown promise in reducing motor impairment when combined with rehabilitation therapy. Sarah Passey talks to Wayne Feng (Duke University School of Medicine, Durham, NC, USA) about his latest trial, TRANSPORT2, which assesses transcranial direct current stimulation in combination with modified constraint-induced movement therapy.

Read the full article:

https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(25)00044-4/fulltext?dgcid=buzzsprout_icw_podcast_16-04-25_laneur

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In this podcast, linked to the April 2025 issue of The Lancet Neurology, Laura Hart (Deputy Editor) chats to Marialuisa Gandolfi (University of Verona in Italy) about advances in the classification and management of pain in Parkinson’s disease.

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Sarah Passey (The Lancet Neurology) is joined by Michael Tymianski (University Health Network, Toronto, Canada) to discuss an Article in the March issue reporting a meta-analysis looking at neuroprotection in stroke and what can be learnt for future research.

Read the full article:

https://www.thelancet.com/journals/laneur/article/PiiS1474-4422(24)00515-5/fulltext?dgcid=buzzsprout_icw_podcast_generic_laneur

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In this podcast, linked to the February 2025 issue of The Lancet Neurology, Elena Becker-Barroso (Editor-in-Chief) chats to Elizabeth Finger (Western University, London, ON, Canada) about the FOXY trial of oxytocin for apathy in people with frontotemporal dementia.

Read the full article:
https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(24)00456-3/fulltext?dgcid=buzzsprout_icw_podcast_generic_laneur

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The Lancet Neurology Editors take a look back at advances in neurology in 2024, as highlighted by experts in a series of Round-ups published in the January issue.

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Florian Krismer (Innsbruck Medical University) and Elizabeth Coon (Mayo Clinic) join Sarah Passey (The Lancet Neurology) to discuss their Review paper on multiple system atrophy, which is published in the December issue of The Lancet Neurology.

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