William H. Sauer, MD, FHRS, CCDS, Brigham and Women's Hospital is joined by Ezim Ajufo, MD, Brigham and Women's Hospital and Victor Nauffal, MD, Brigham and Women's Hospital to discuss the Patients with rare, pathogenic cardiomyopathy (CM) and arrhythmia variants that can present with atrial fibrillation (AF). The efficacy of AF ablation in these patients is unknown. This study tested the hypotheses that: 1) patients with a pathogenic variant in any CM or arrhythmia gene have increased recurrence following AF ablation; and 2) patients with a pathogenic variant associated with a specific gene group (arrhythmogenic left ventricular CM [ALVC], arrhythmogenic right ventricular CM, dilated CM, hypertrophic CM, or a channelopathy) have increased recurrence.

https://www.hrsonline.org/education/TheLead https://doi.org/10.1016/j.jacep.2024.06.035

Host Disclosure(s): W. Sauer: Honoraria/Speaking/Consulting: Biotronik, Biosense Webster, Inc., Abbott, Boston Scientific, Research: Medtronic

Contributor Disclosure(s): E. Ajufo: Nothing to disclose. V. Nauffal: Nothing to disclose.